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65 results for “Taxol”
Sulfo-SMCC Prevents Annealing of Taxol-Stabilized Microtubules In Vitro
<p>The data consists of raw images analyzed for the paper 'Sulfo-SMCC Prevents Annealing of Taxol-Stabilized Microtubules In Vitro'.</p> <ol> <li>For all files: different data sets are indicated by using prefix A, 2A , 3A for untreated microtubules, and prefix B, 2B, 3B for sulfo-SMCC treated microtubules.</li> <li>Filenames that include time points of 0 h, 6 h, or 24 h show images of treated and untreated microtubules at different time points. This data was used for Fig 1 in the paper.</li> <li>The files with prefix 'dual' refer to data from dual colored experiments. Microtubules were labeled with green dye (488 in filenames) and red dye (TMR in filenames). This data was used for Fig 2 in the paper.</li> <li>The files with prefix 'chemical' are from one experiment with different chemical treatments on MTs. This data was used for Fig 3 in the paper.</li> </ol>
A Phase 1/2 Study of HKI-272 (Neratinib) in Combination With Paclitaxel (Taxol) in Subjects With Solid Tumors and Breast Cancer
ClinicalTrials.gov study NCT00445458. IPD Sharing: Not stated. Countries: 9. Publications: 1.
Sutent + Taxol for Advanced Esophageal Cancer
ClinicalTrials.gov study NCT00730353. IPD Sharing: NO. Countries: 1. Publications: 1.
A Randomized Trial of Ixempra Versus Taxol in Adjuvant Therapy of Triple Negative Breast Cancer
ClinicalTrials.gov study NCT00789581. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Study of Dose-dense Adriamycin Plus Cytoxan (AC) Followed by Either ABI-007 (Abraxane) or Taxol With Bevacizumab as Adjuvant Therapy for Patients With Breast Cancer
ClinicalTrials.gov study NCT00394251. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Phase 2 Study of Gemzar, Taxol & Avastin Combination as 1st Line Treatment for Metastatic Breast Cancer
ClinicalTrials.gov study NCT00403130. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: Recent population decline and selection shape diversity of taxol-related genes
Taxanes are defensive metabolites produced by Taxus species (yews) and used in anticancer therapies. Despite their medical interest, patterns of natural diversity in taxane related genes are unknown. We examined variation at five main taxol-related genes of T. baccata in the Iberian Peninsula, a region where unique yew genetic resources are endangered. We looked at several gene features and applied complementary neutrality tests, including diversity/divergence tests, tests solely based on site-frequency spectrum and Zeng's compound tests. To account for specific demography, microsatellite data were used to infer historical changes in population size based on an Approximate Bayesian Computation (ABC) approach. Polymorphism-divergence tests pointed to positive selection for genes TBT and TAT, and balancing selection for DBAT. In addition, neutrality tests based on site-frequency spectrum found that while a recent reduction in population size may explain most of statistics' values, selection may still be in action in genes TBT and DBAT, at least in some populations. Molecular signatures on taxol genes suggest the action of frequent selective waves with different direction or intensity, possibly related to varying adaptive pressures produced by the host-enemy co-evolution on defense-related genes. Such natural selection processes may have produced taxane variants still undiscovered.
Fig. 7 in Sites of biosynthesis and storage of Taxol in Taxus media (Rehder) plants: Mechanism of accumulation
Fig. 7. Model summarizes the dynamic production of Taxol in Taxus plant stem sections suggesting wood as the site of Taxol biosynthesis, and phloem and outer bark as the sites of storage.
Fig. 6 in Sites of biosynthesis and storage of Taxol in Taxus media (Rehder) plants: Mechanism of accumulation
Fig. 6. In situ immuno-labelling of TS enzyme and Taxol in Taxus stem transverse sections. (A) Control stem section received no primary Abs compared to (B) a section that received anti-TS Ab and (C) a section that received anti-Taxol Ab.
Fig. 5 in Sites of biosynthesis and storage of Taxol in Taxus media (Rehder) plants: Mechanism of accumulation
Fig. 5. Comparison between Taxus plant (A-G) tissues, (H–N) organs and (O–W) age on the contents of (A, H, O) Taxol (B, I, P) baccatin III, (C, J, Q) polyphenols, (D, K, R) HB and the expression of (E, L, S) TS, (F, M, T) PAL and (G, N, W) PAM genes. In case of (D) the comparison was between wood and phloem only, since the bark did not show HB. The data are displayed as the mean ± standard error of the mean. The statistical significance was calculated with a Student-T-test and oneway ANOVA, and the significance level indicated by asterisks. P-value <0.05 was considered significant.
Fig. 4 in Sites of biosynthesis and storage of Taxol in Taxus media (Rehder) plants: Mechanism of accumulation
Fig. 4. Comparison between intact plant and plant callus culture (TC) in terms of (A) taxoid contents (Taxol versus baccatin III), number of HB (indicated as red droplets) in (B) TC and (C) intact plant stem sections, and expression of (D and E) TS, (F) PAL and (G) PAM genes. The data are displayed as the mean ± standard error of the mean. The statistical significance was calculated with the Student-t-test and the significance level indicated by asterisks. P-value <0.05 was considered significant. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Fig. 2 in Sites of biosynthesis and storage of Taxol in Taxus media (Rehder) plants: Mechanism of accumulation
Fig. 2. Taxol localization and storage. (A) Transverse section of a Taxus plant stem showing the location of Taxol-containing HB (red-stained droplets) within the wood and phloem in comparison to (B) close up view in the vascular bundle (VB) of a root section and (C) close up view in the vascular bundle (VB) of a needle (Taxus leaf) section. (D) and (E) Close up views in the wood and phloem, respectively, to show the distribution of Taxol-containing HB within Taxus stem sections. (F) Pearson's correlation between Taxol content and the number of HB within different plant samples (Pearson's correlation, r2 = 0.77). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
Fig. 3 in Sites of biosynthesis and storage of Taxol in Taxus media (Rehder) plants: Mechanism of accumulation
Fig. 3. Correlation of Taxol accumulation to (A) baccatin III accumulation (Pearson's correlation, r2 = 0.12), (B) polyphenol accumulation (Pearson's correlation, r2 = 0.95) and (C) TS gene expression (Pearson's correlation, r2 = 0.07). (D) Correlation of baccatin III to TS gene expression (Pearson's correlation, r2 = 0.80). The data were analyzed using Pearson's correlation and the data were considered to have a normal distribution. P value <0.05 was considered as significant.
Pazopanib (VOTRIENT) Plus Paclitaxel (TAXOL), Pazopanib Plus Paclitaxel (TAXOL) Plus Carboplatin (PARAPLATIN), and Pazopanib Plus Paclitaxel (TAXOL) Plus Lapatinib (TYKERB)
ClinicalTrials.gov study NCT00388076. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Exploratory Study on the Use of Pregabalin for the Treatment of Taxol Related Arthralgia-Myalgia
ClinicalTrials.gov study NCT02024568. IPD Sharing: Not stated. Countries: 1. Publications: 14.
Phase 3 Study to Compare Efficacy and Safety of DHP107 vs. Taxol® in Patients With Metastatic or Recurrent Gastric Cancer
ClinicalTrials.gov study NCT01839773. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Evaluation of Paclitaxel (Taxol, NSC #673089), Carboplatin (Paraplatin, NSC #241240), and BSI-201 (NSC #746045, IND #71,677) in the Treatment of Advanced, Persistent, or Recurrent Uterine Carcinosarco
ClinicalTrials.gov study NCT00687687. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Pilot Trial of AC (Adriamycin, Cyclophosphamide) Chemotherapy With G-CSF (Granulocyte Colony-Stimulating Factor) Followed by Infusional Taxol (Paclitaxel) as Adjuvant Treatment for High Risk Stage I
ClinicalTrials.gov study NCT00001384. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Phase II Trial of Pulsed Taxol With Concurrent Thoracic Radiotherapy, & Adjuvant Chemo in Stage III NSCLC
ClinicalTrials.gov study NCT00449657. IPD Sharing: Not stated. Countries: 1. Publications: 16.
Taxol(Paclitaxel),UFT and Leucovorin in Patients With Advanced Gastric Cancer
ClinicalTrials.gov study NCT00154778. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
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OpenNeuro
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