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86 results for “Tetracycline”
Cell growth dataset for "Suppression of bacterial cell death underlies the antagonistic interaction between ciprofloxacin and tetracycline in Escherichia coli"
<div>This dataset contains growth data of <em>E. coli</em> cells measured by optical density at a wavelenght of 600 nm (OD600) to determine the conditions where the combination of ciprofloxacin (CIP) and tetracycline (TET) is antagonistic (or suppressive), using a medium that supports fast, intermediate and slow growth (M9 based medium supplemented with: glucose and amino acid, glucose, and glycerol, respectively).</div> <div>Two types of assays were performed: a checkerboard assay with a 2-dimension gradient of antibiotic concentrations shown in "Fig-S1-Growth_rates-Checkerboard_assay.zip", and bulk growth rates assay shown in "Fig-S2-Bulk_doubling_rates-Bioreactor.zip". </div> <div>These experiments are presented in the supplementary figures of the following manuscript published as preprint in bioRxiv: https://doi.org/10.1101/2024.04.18.590101.</div> <div> </div> <p><strong>Fig-S1-Growth_rates-Checkerboard_assay.zip:</strong></p> <div>- growth-OD600-Blank_correct.xlsx: contains the blank corrected (subtracted by initial OD of sterile medium) OD600 data for each well measured in the checkerboard assay. The negative control is named as "Blank B" in the spreasheet and the antibiotic concentrations for each well is defined in column C (Content).</div> <div>- growth_data.xlsx: contains the processed data from "Growth-OD600-Blank_correct.xlsx":growth curves were smoothed with a 5-window moving median and outliers corrected using the filloutliers function in MATLAB. Outliers that were missed were manually corrected.</div> <div>- time_h.xlsx: contains the time in hours used by the matlab function to build the dose response figure S1B.</div> <div>- analysis_code_checkerboard_assay.m: matlab function used to build the dose response figure S1B.</div> <p> </p> <p><strong>Fig-S2-Bulk_doubling_rates-Bioreactor.zip:</strong></p> <p>- "bulk_doubling rates_gly/glu/gluaa.csv": contains the calculated doubling rates for each of three experimental replicates (rows) and for each antibiotic treatment (columns: Ctrl, CIP, TET, CIP-TET) as shown in Figure S2. These values were used to calculated the Bliss independence (for further details see https://gitlab.com/MEKlab/single-cell-suppression-2024/figure plotting.ipynb<br> - Folders containing OD600 measurements and calculated growth rates for each growth medium, which are further separated into folders for each experimental replicate. Each replicate folder is labelled as the date the experiment was performed (denoted as "*" hereon). Each contains the following: raw optical density data (*.txt files), summary of experiment and results (*.docx file), the function compute_growth_rates.m, and the script Growth_curves_*.m.</p> <div>For more information on methods, strains used and table header descriptions, please refer to the README.txt. </div>
Putative mutations associated with tetracycline resistance detected in Treponema spp.- an analysis of 4,355 Spirochaetales genomes
<p>Supplementary Table 1–4, , as well as multiple sequence alignment files for 16S rRNA, rpsC, and rpsJ loci, have been deposited.</p> <p>Additionally, the archive contains a <code>scripts.txt</code> file that includes all custom Bash scripts used for:</p> <ul> <li> <p>rRNA gene detection and quantification using <em>Barrnap</em></p> </li> <li> <p>Genome quality assessment using <em>CheckM</em></p> </li> <li> <p>Gene-by-gene schema creation, allele calling, and cgMLST extraction using <em>chewBBACA</em></p> </li> <li> <p>GFF merging and wide-format transformation for summarizing rRNA copy number per genome</p> </li> </ul> <p>These materials are provided to ensure reproducibility of the analyses and to support further investigations into antimicrobial resistance in <em>Spirochaetales</em>.</p>
Comparison of tetracycline and temperature sensitive GAL80 transgenes with UAS-lacZ
<p>ß-galactosidase specific activity was measured during development and aging (Experimental workflow) as described in <a href="https://star-protocols.cell.com/protocols/2150">STAR Protocols 3, 101843, 2022</a>. Two different muscle-specific GAL4 drivers, Mef2-Gal4 (BDSC:27390) and DJ694 (BDSC: 8176), were each crossed with a second chromosome insertion of UAS-lacZ (Bg2) (BDSC: 1776), Bg2 recombined with third chromosome insertions of TetOFF-GAL80 (3.3+1077, <a href="https://peerj.com/articles/4167/">PeerJ 5:e4167</a>), and Bg2 recombined with third chromosome insertions of GAL80ts (BDSC:7017). Flies were raised at 20˚C and 29℃. Two independent sets of parents were used for each cross (biological replicates 1 and 2). After 2-3 days, parents were flipped into a new bottles (technical replicates 1 and 2 reported as replicate 3 and 4 in the dataset). CPRG and Bradford assays were performed on whole animal for the third instar larvae (L3), early pupae (EP) and late pupae (LP) stages, and on dissected thoraces for adult stages. Five extracts (1 individual in each) were measured per experimental replicate. Raw microplate readings are available upon request.</p>
Comparison of tetracycline and temperature sensitive GAL80 transgenes with UAS-grim
<p>In order to assess the ability of GAL80 to repress the expression of a UAS transgene, lethality tests were performed in presence of a UAS-grim reporter (<a href="http://doi.org/10.1002/gene.10128"><em>Genesis</em> 34:34, 2002</a>, <a href="https://peerj.com/articles/4167/"><em>PeerJ</em> 5:e4167, 2017</a>). The Grim reporter gene encodes a strong pro-apoptotic factor, thus the lethality across development (embryonic, larval, pupal) can be scored to assess the repression ability of GAL80. The UAS-grim lethality test facilitates the determination of the developmental period during which GAL4 activity is not inhibited.</p> <p>Two different muscle-specific GAL4 drivers, Mef2-Gal4 (BDSC:27390) and DJ694 (BDSC: 8176), were each crossed with a second chromosome insertion of UAS-grim (<a href="https://doi.org/10.1038/sj.cdd.4400423">Cell Death Differ 5:930,1998</a>), UAS-grim recombined with third chromosome insertions of GAL80TET (3.3+1077, <a href="https://peerj.com/articles/4167/">PeerJ 5:e4167</a>), and UAS-grim recombined with third chromosome insertions of GAL80ts (BDSC:7017). Negative control (no lethality) was generated by crossing the UAS-grim strain with a strain without any GAL4 transgene (w<sup>1118</sup>,<a href="https://www.cell.com/cell/pdf/0092-8674(84)90240-X.pdf?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2F009286748490240X%3Fshowall%3Dtrue">Cell 36:469, 1984</a> ). Crosses were maintained, and eggs were collected at 20˚C (Experimental workflow). Parents were obtained from multiple independent cultures to set-up independent crosses (biological replicates, Set indicates parents from the same culture). Crosses were kept 24 to 48h in culture tubes to allow mating before transferring them to egg collectors. Multiple egg collections were done for each parental set (technical replicates, Date indicates dates of collection). Parents were allowed to lay eggs for 12h to 16h. Up to 25 eggs were aligned on a slice of food and up to 4 slices were used for a given collection from a set. Slices of food are then transferred to culture vials and incubated at the indicated temperature. The scoring of the number of first-instar larvae (L1) was done by scoring the number of empty eggs 25-30h (29˚C) or 43-48h (20˚C) after egg alignment. The number of pupae and adults was scored 5-6 days (29˚C) or 8-10 days (20˚C) after the scoring of the previous stage.</p>
Data from: Direct and trans-generational effects of tetracyclines on the microbiome, transcriptome, and male mating behavior of the sheep blowfly Lucilia cuprina
Open the record for dataset details and reuse information.
Tetracycline as a Prophylaxis for Rash in Patients With NSCLC Receiving Treatment With BIBW2992 (Afatinib)
ClinicalTrials.gov study NCT01880515. IPD Sharing: Not stated. Countries: 1. Publications: 20.
Nitrogen and phosphorus concentrations shape tetracycline effects on Microcystis aeruginosa and Microcystis flos-aquae
<p>Continuous contamination of aquatic resources with broad-spectrum antibiotics, such as tetracycline, nitrogen and phosphorus disrupts the population dynamics of non-target organisms, including cyanobacteria, in freshwater ecosystems.</p>
Intralesional Tetracycline Injection in the Treatment of Chalazia
ClinicalTrials.gov study NCT01763437. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Tegoprazan-Based Dual Therapy With Amoxicillin vs Tetracycline for H. Pylori Eradication
ClinicalTrials.gov study NCT06977841. IPD Sharing: NO. Countries: 1. Publications: 1.
Helicobacter Rescue Therapy With Berberine Plus Amoxicillin Quadruple Therapy Versus Tetracycline Plus Furazolidone Quadruple Therapy
ClinicalTrials.gov study NCT03609892. IPD Sharing: NO. Countries: 1. Publications: 1.
Efficacy and Safety of Bismuth Quadruple Therapy Containing Cefuroxime and Tetracycline as First-line Therapy for Eradicating Helicobacter Pylori in Patients Allergic to Penicillin
ClinicalTrials.gov study NCT06351891. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Tetracycline to Limit the Innate Immune Response in Acute Respiratory Distress Syndrome
ClinicalTrials.gov study NCT04079426. IPD Sharing: NO. Countries: 1. Publications: 1.
Non-surgical Treatment of Peri-implantitis Using Chitosan Brush and Tetracycline Slurry
ClinicalTrials.gov study NCT06695559. IPD Sharing: NO. Countries: 1. Publications: 9.
High Dose Amoxicillin Versus Tetracycline as Second-line Treatment of Resistant Helicobacter Pylori Infection
ClinicalTrials.gov study NCT02175927. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Comparison of the Effectiveness of Povidone-Iodine Alone to Povidone-Iodine-Tetracycline Combination
ClinicalTrials.gov study NCT04039126. IPD Sharing: YES. Countries: 1. Publications: 3.
Tetracycline-Derivatives for Treatment of Cerebral Arteriovenous Malformations and Aneurysms
ClinicalTrials.gov study NCT00243893. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Tetracycline in Preventing Skin Rash in Patients Who Are Receiving Drugs Such as Gefitinib and Cetuximab for Cancer
ClinicalTrials.gov study NCT00091247. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Bismuth Quadruple Therapy for Helicobacter Pylori Rescue Therapy of Different Tetracycline Doses and Frequencies.
ClinicalTrials.gov study NCT05432115. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Evaluate the PK of Multiple Oral Doses of Tegoprazan, Metronidazole, Tetracycline and Bismuth in Healthy Volunteers
ClinicalTrials.gov study NCT04066257. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Bismuth Quadruple Therapy in Helicobacter Pylori Rescue Therapy of Different Tetracycline Doses and Frequencies.
ClinicalTrials.gov study NCT05802888. IPD Sharing: Not stated. Countries: 1. Publications: 8.
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