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168 results for “Toxicology”
PretoxTM Corpus: a gold standard corpus of preclinical treatment-related findings annotated from toxicology reports
<p>The PretoxTM Corpus is a gold standard corpus of preclinical treatment-related findings annotated from toxicology reports.</p> <p>Example documents annotated by domain experts, also known as a gold standard corpus, are needed in order to develop, train, and validate text mining tools. To this aim we designed and performed an annotation activity for the development of the corpus of treatment-related findings: the PretoxTM corpus.</p> <p>A treatment-related finding expression enclose several named entities; the most relevant one is the abnormal effect detected; which depending on the study domain of the finding, can be given by a measurement, test, or examination named Study Test and an abnormal Manifestation result obtained for that study test; or by an abnormal Finding in study domains where there is no associated test or measurement (e.g., clinical, macroscopic and microscopic). Other related named entities that could be present to complete the treatment-related finding are; the Specimen of the abnormal observation, the Sex of the subject, the Group of subjects in which the observation was detected and the Dose level administration of the compound. Examples of sentences with treatment-related findings are: “The decrease in food consumption and body weight of the animals from the mid dose onwards is regarded as evidence of general toxicity.” and "At dose level 3, absolute and relative liver weights were increased in male rats.”.</p> <p>Contributions: The PretoxTM corpus was developed by BSC, with the contribution of IMIM and a team of experts from the eTRANSAFE EFPIA partners.</p> <p>License: Creative Commons Attribution-ShareAlike 4.0 International (cc by sa 4.0).</p> <p>The PretoxTM resources have been developed as part of the eTRANSAFE project.</p> <p>For more information about PretoxTM please visit:</p> <p>PretoxTM Corpus Gitlab: <a href="https://gitlab.bsc.es/inb/etransafe/preclinical-toxicological-corpus/">https://gitlab.bsc.es/inb/etransafe/preclinical-toxicological-corpus/</a></p> <p>PretoxTM central documentation: <a href="https://pretoxtm.gitlab.io/documentation/">https://pretoxtm.gitlab.io/documentation/</a></p>
Figure 1 in Integrative analysis in toxicological assessment of the insecticide Malathion in Allium cepa L. system
Figure 1. Rates of alterations found for Allium cepa cells exposed for 48h to distilled water (H O – negative control), 0.5 mg mL-1, 2 d 1.0 mg mL-1 of Malathion and methyl methanesulfonate (MMS – positive control), concerning: (A) anaphase bridge; (B) chromosome loss; (C) chromosome delay; (D) micronuclei index. KW-H = results of Kruskal-Wallis test and p = value of the statistical probability. Letters on the error bars indicate the result of the statistical Mann-Whitney U test.
Figure 3 in Integrative analysis in toxicological assessment of the insecticide Malathion in Allium cepa L. system
Figure 3. Discriminant canonical function, showing the distribution of the centroids e of the groups of the different treatments; 1: treatment submitted to distilled water; 4: positive control with MMS; 2 and 3: groups exposed to Malathion, for 0.5 e 1.0 mg mL-1 concentrations, respectively.
Figure 2 in Integrative analysis in toxicological assessment of the insecticide Malathion in Allium cepa L. system
Figure 2. Mitotic index at the radicular meristematic region of Allium cepa cells, after exposure for 48 hours to distilled water (H Od – negative control), 0.5 mg mL-1, 1.0 mg mL-1 of Malathion 2 and methyl methanesulfonate (MMS – positive control). KW-H = results of Kruskal-Wallis test and p = value of the statistical probability. Letters on the error bars indicate the result of the statistical Mann-Whitney U test.
Figure 3 in Analysis of the toxicological and pharmacokinetic profile of Kaempferol-3-O-β-D-(6"-E-p-coumaryl) glucopyranoside - Tiliroside: in silico, in vitro and ex vivo assay
Figure 3. Photomicrography of exfoliated oral mucosa cells with: (A) karyorrhexis; (B) karyolysis; (C) micronucleus; (D) binucleation; and (E) macronucleus. Magnification X1000.
Figure 2 in Analysis of the toxicological and pharmacokinetic profile of Kaempferol-3-O-β-D-(6"-E-p-coumaryl) glucopyranoside - Tiliroside: in silico, in vitro and ex vivo assay
Figure 2. Cytotoxic effect of tiliroside (H. velutina) against RBC; (C-) Negative control (erythrocytes 0.5%), (C+) Positive control (1% Triton X-100). P <0.05 (*), P <0.01(**) and P <0.001 (***) versus positive control.
Fig 1A in Toxicological assessments of basic blue 3 dye in fresh water bivalve Lamellidens marginalis
Fig 1A: Section passing through gill of fresh water bivalve Lamellidensmarginalisfrom control group (400X). B: Effect of 40 ppm (LC0) of Basic Blue 3 on gill of fresh water bivalve Lamellidensmarginalis after 96 hours exposure (400X) C: Effect of 70 ppm (LC50) of Basic Blue 3 on gill of fresh water bivalve Lamellidenmarginalis after 96 hours exposure (400X)
Fig 2A in Toxicological assessments of basic blue 3 dye in fresh water bivalve Lamellidens marginalis
Fig 2A: Section passing through hepatopancreas of fresh water bivalve Lamellidens marginalis from control group (400X). B: Effect of 40 ppm (LC0) of Basic Blue 3 on hepatopancreas of fresh water bivalve Lamellidens marginalis after 96 hours exposure (400X) C: Effect of 70 ppm (LC50) of Basic Blue 3 on hepatopancreas of fresh water bivalve Lamellidens marginalis after 96 hours exposure (400X)
Fig 4A in Toxicological assessments of basic blue 3 dye in fresh water bivalve Lamellidens marginalis
Fig 4A: Photomicrogragh of gill cell of Lamellidens marginalis for 96 hours exposure; degree of damage class 0 B: Photomicrogragh of gill cell of Lamellidens marginalis for 96 hours exposure to 40 ppm concentration of Basic blue 3; degree of damage class 0 C: Photomicrogragh of gill cell of Lamellidens marginalis for 96 hours exposure to 70 ppm concentration of Basic blue 3; degree of damage class I
Data & code repository for the article "A network toxicology approach for mechanistic modelling of nanomaterial hazard and adverse outcomes"
<p>This repository contains the relevant data and code supporting the study "A network toxicology approach for mechanistic modelling of nanomaterial hazard and adverse outcomes". </p> <p>In detail the following data sources have been included:</p> <ul> <li>the relevant code and supporting data (code_to_upload.zip and supporting_data.zip);</li> <li>supplementary materials of the paper, including: <ul> <li>individual enrichment results of the 93 exposures to the 31 ENMs (enrichments_results.zip);</li> <li>comparison between the mechanism of action retrieved from differentially expressed genes and network modelling (network_comparison_results.zip);</li> <li>overrepresented network edges in categories of networks (overrepresented_structures.zip)</li> </ul> </li> </ul>
Fig 3A in Toxicological assessments of basic blue 3 dye in fresh water bivalve Lamellidens marginalis
Fig 3A: Section passing through gonad of fresh water bivalve Lamellidens marginalis from control group (400X). B: Effect of 40 ppm (LC0) of Basic Blue 3 on gonad of fresh water bivalve Lamellidens marginalis after 96 hours exposure (400X) C: Effect of 70 ppm (LC50) of Basic Blue 3 on gonad of fresh water bivalve Lamellidens marginalis after 96 hours exposure (400X)
Graph 1 in Toxicological assessments of basic blue 3 dye in fresh water bivalve Lamellidens marginalis
Graph 1: Changes in SODactivity in different tissues of fresh water bivalve, Lamellidens marginalis after acute exposure to basic blue 3(values are expressed in unit/mg protein/hour)
Graph 4 in Toxicological assessments of basic blue 3 dye in fresh water bivalve Lamellidens marginalis
Graph 4: DNA strand breaks in gill cells of Lamellidens marginalis after acute exposure to Basic blue 3.
Graph 2 in Toxicological assessments of basic blue 3 dye in fresh water bivalve Lamellidens marginalis
Graph 2: Changes in CAT activity in different tissues of fresh water bivalve, Lamellidens marginalis after acute exposure to basic blue 3 (values are inmmolH2O2/min/mg protein)
Graph 3 in Toxicological assessments of basic blue 3 dye in fresh water bivalve Lamellidens marginalis
Graph 3: Changes in GPx activityin different tissues of fresh water bivalve, Lamellidens marginalis after acute exposure to basic blue 3 (values are in mmol NADPH/min/mg protein)
Fig. 2a, b in Morphological, ecological and toxicological aspects of Raphidiopsis raciborskii (Cyanobacteria) in a eutrophic urban subtropical lake in southern Brazil
Fig. 2a, b. Bar graphs indicating the relative percentages of different phytoplankton groups in the lake inflow (a) and outflow (b), sampled every month from November 2009 to November 2010.
Fig. 6 in Morphological, ecological and toxicological aspects of Raphidiopsis raciborskii (Cyanobacteria) in a eutrophic urban subtropical lake in southern Brazil
Fig. 6. Principal Component Analysis (PCA) ordination of the sampling units (P1) = water inflow and (P2) = water outflow, and of the physical and chemical variables analyzed. The sampling units are listed by month abbreviated as follows: Jan = January; Feb = February; Mar = March; Apr = April; May = May; Jun = June; Jul = July; Aug = August; Sept = September; Oct = October; Nov = November; Dec = December. T = Temperature; Transp = Transparency; Cond = Conductivity; DO = Dissolved oxygen; NH4 = Ammonium; OM = Organic material.
Fig. 4a-c in Morphological, ecological and toxicological aspects of Raphidiopsis raciborskii (Cyanobacteria) in a eutrophic urban subtropical lake in southern Brazil
Fig. 4a-c. Photomicrographs of Raphidiopsis raciborskii bloom from the studied lake demonstrating: a. general aspect of the bloom; c. part of a trichome with a heterocyte and an akinete; c. part of a trichome with only an akinete. Bars =10µm.
Fig. 1 in Morphological, ecological and toxicological aspects of Raphidiopsis raciborskii (Cyanobacteria) in a eutrophic urban subtropical lake in southern Brazil
Fig. 1. Map of the studied lake, showing the two sampling sites (I = water inflow and O = water outflow).
Integrated Effect Database for Toxicological Observations (INTOB)
<p>This dataset contains morphological observations of zebrafish embryos from toxicological experiments from the department of Ecotoxicology at the Helmholtz-Center for Environmental Research (UFZ). Data was recorded via <a href="https://www.ufz.de/intob/index.php?en=51326">INTOB</a>, a software to collect and manage data and metadata from toxicological observations.</p> <p>The dataset contains two directories, <code>data/</code>which contains experimental data, and <code>scripts/</code> which contains all code needed to run the analysis described in the paper, as well as a compiled HTML file. <code>results/</code> contains a table with EC50 and LC50 values as visualised in Figure 3 of the paper.</p> <p><code>data/intob_data/</code> contains several csv files:</p> <ul> <li><code>effect_list_info.csv</code> contains all possible effects of the database and their relation to each other</li> <li><code>obs_phenotypes.csv</code> contains all individual observations</li> <li><code>metadata.csv</code> lists metadata about the experiments and substances</li> <li><code>plate_layout.csv</code> contains experimental setups, i.e. layouts of substances and concentrations in well-plates or vials</li> <li><code>phys_chem_prop.csv</code> contains the physico-chemical observations of the substances</li> </ul> <p><code>data/data_for_analysis/</code> contains files required in the script and <code>data/zotero_phenotype_library/</code> contains the results of the literature review described in the paper in JSON format.</p>
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Allen Brain Atlas
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International Brain Laboratory public data
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OpenNeuro
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