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8 results for “Trabecular bone score”
THE EFFECT OF BODY SIZE AND COMPOSITION ON LUMBAR SPINE TRABECULAR BONE SCORE IN MORPHOLOGICALLY DIVERSE SUBJECTS
<p><strong>Aim:</strong> The trabecular bone score (TBS) is a tool for assessing bone quality and health. Current TBS algorithm corrects for body mass index (BMI), as a proxy of regional tissue thickness. However, this approach fails to consider BMI inaccuracies due to individual differences in body stature, composition and somatotype. This study investigated the relationship between TBS and body size and composition in subjects with a normal BMI, but with large morphological diversity in body fatness and height.</p> <p><strong>Methods:</strong> Young male subjects (n=97; age 17.2±1.0 years), including ski jumpers (n=25), volleyball players (n=48) and non-athletes (controls n=39), were recruited. The TBS was determined from L1-L4 dual-energy X-ray absorptiometry (DXA) scans using TBSiNsight software.</p> <p><strong>Results:</strong> TBS correlated negatively with height and tissue thickness in the L1-L4 area in ski jumpers (r= -0.516 and r= -0.529), volleyball players (r= -0.525 and r= -0.436), and the total group (r=-0.559 and r=-0.463), respectively. Multiple regression analyses revealed that height, L1-L4 soft tissue thickness, fat mass and muscle mass were significant determinants of TBS (R<sup>2</sup>= 0.587, p<0.001). L1-L4 soft tissue thickness explained 27% and height 14% of the TBS variance.</p> <p><strong>Conclusion: </strong>The negative association of TBS and both features suggests that a very low L1-L4 tissue thickness may lead to overestimation of the TBS, while tall stature may have the opposite effect. It seems that the utility of the TBS as a skeletal assessment tool in lean and/or tall young male subjects could be improved if tissues thickness in the lumbar spine area and stature instead of BMI were considered in the algorithm.</p>
Effect of GLP-1 Receptor Agonists on Trabecular Bone Score
ClinicalTrials.gov study NCT04964388. IPD Sharing: NO. Countries: 1. Publications: 0.
Longitudinal Effects of Denosumab on Trabecular Bone Score and Femur Strength Index
ClinicalTrials.gov study NCT02435147. IPD Sharing: NO. Countries: 1. Publications: 0.
Study of Bone Mineral Density and Trabecular Bone Score in Patients With Ankylosing Spondylitis
ClinicalTrials.gov study NCT04392596. IPD Sharing: NO. Countries: 1. Publications: 0.
Trabecular Bone Score in Multiple Sclerosis
ClinicalTrials.gov study NCT05811689. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Study of Trabecular Bone Score (TBS) as a Fracture Risk Factor in Chronic Renal Failure
ClinicalTrials.gov study NCT03356522. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Osteoporosis, Trabecular Bone Score and Fracture Risk Assessment in Male Patients After Radical Cystectomy
ClinicalTrials.gov study NCT04153227. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Dataset related to article "Denosumab improves trabecular bone score in relationship with decrease in fracture risk of women exposed to aromatase inhibitors "
<p>This record contains raw data related to article "Denosumab improves trabecular bone score in relationship with decrease in fracture risk of women exposed to aromatase inhibitors"</p><p>Abstract</p><p><strong>Purpose: </strong>Trabecular bone score (TBS) is a gray-level textural metric that has shown to correlate with risk of fractures in several forms of osteoporosis. The value of TBS in predicting fractures and the effects of bone-active drugs on TBS in aromatase inhibitors (AIs)-induced osteoporosis are still largely unknown. The primary objective of this retrospective study was to assess the effects of denosumab and bisphosphonates (BPs) on TBS and vertebral fractures (VFs) in women exposed to AIs.</p><p><strong>Methods: </strong>241 consecutive women (median age 58 years) with early breast cancer undergoing treatment with AIs were evaluated for TBS, bone mineral density (BMD) and morphometric VFs at baseline and after 18-24 months of follow-up. During the study period, 139 women (57.7%) received denosumab 60 mg every 6 months, 53 (22.0%) BPs, whereas 49 women (20.3%) were not treated with bone-active drugs.</p><p><strong>Results: </strong>Denosumab significantly increased TBS values (from 1.270 to 1.323; P < 0.001) accompanied by a significant decrease in risk of VFs (odds ratio 0.282; P = 0.021). During treatment with BPs, TBS did not significantly change (P = 0.849) and incidence of VFs was not significantly different from women untreated with bone-active drugs (P = 0.427). In the whole population, women with incident VFs showed higher decrease in TBS vs. non-fractured women (P = 0.003), without significant differences in changes of BMD at any skeletal site.</p><p><strong>Conclusions: </strong>TBS variation predicts fracture risk in AIs treated women. Denosumab is effective to induce early increase of TBS and reduction in risk of VFs</p>
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