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180 results for “Transduction”
Data: DEAE-Dextran enhances the lentiviral transduction of primary human mesenchymal stromal cells from all major tissue sources without affecting their proliferation and phenotype
<p>This data set includes all the raw data collected for the following article: "DEAE-Dextran enhances the lentiviral transduction of primary human mesenchymal stromal cells from all major tissue sources without affecting their proliferation and phenotype"</p>
Data and code for figures: Kinetic Inductive Electromechanical Transduction for Nanoscale Force Sensing
<p>This directory contains the datasets and code (if applicable) for generating the figures in the research article "Kinetic Inductive Electromechanical Transduction for Nanoscale Force Sensing", Physical Review Applied 20, 024022 (2023).</p>
Single molecule dataset for article: Multistep orthophosphate release tunes actomyosin energy transduction
<table> <tbody> <tr> <td> <p>Dataset (single molecule movies) that is behind the results in the article's Figure 2 and Figure 3.</p> <p>MATLAB scripts used to analyze the dataset. </p> </td> </tr> </tbody> </table> <p> </p>
Dataset for: All-atom simulations reveal the intricacies of signal transduction upon binding of HLA-E ligand to the transmembrane inhibitory CD94/NKG2A receptor
<p>This dataset contains relevant structures, input and other files that are associated with our article "<em>All-atom simulations reveal the intricacies of signal transduction upon binding of HLA-E ligand to the transmembrane inhibitory CD94/NKG2A receptor", available at https://pubs.acs.org/doi/full/10.1021/acs.jcim.3c00249</em></p>
Figure 2 in Molecular transduction in receptor-ligand systems by planar electromagnetic fields
Figure 2. TCR(αβ) molecules in free (a, b, c) and coupled (d) states, showing the charged residues in red for negative charges and blue for positive charges. The fully conserved residues are highlighted in the boxes below each figure. Image records taken from Jmol.
Figure 1 in Molecular transduction in receptor-ligand systems by planar electromagnetic fields
Figure 1. Spatial positions of fully conserved, charged residues and peptide-recognition residues in TCR. These together form a PECC-i by which the signal reaches the ζζ transmembrane dimer domain. Image recordings taken from Jmol.
Figure 3 in Molecular transduction in receptor-ligand systems by planar electromagnetic fields
Figure 3. Some examples of PECC-i present in: calcium-ADP pump (a,b,c); haemoglobin-oxygen (d,e,f); and gp120-CD4 (g,h,i) receptorligand protein systems. Image records taken from Jmol.
Data set for "Bidirectional microwave-optical transduction based on integration of high-overtone bulk acoustic resonators and photonic circuits"
<p>The repository contains raw data, processing scripts, simulation and GDS files for the manuscript "Bidirectional microwave-optical transduction based on integration of high-overtone bulk acoustic resonators and photonic circuits". For detailed usage instructions, please take a look at the README.txt file. </p>
Full-length HTT purification from HEK293T suspension culture using baculovirus transduction protocol for over-expression 2018/04/02
<p>Structure-function open lab notebook project. Full-length HTT purification from HEK293T suspension culture using baculovirus transduction protocol for over-expression 2018/04/02.</p>
Data for DRExM³L: Drug REpurposing using eXplainable Machine Learning and Mechanistic Models of signal transduction
<p>(DREM³L) Drug REpurposing using Mechanistic Models of signal transduction and Machine Learning </p>
Data from: Double-strand break repair pathways differentially affect processing and transduction by dual AAV vectors
Open the record for dataset details and reuse information.
Experimental data from Dietler et al. (2022) "Signal Transduction in Light-Oxygen-Voltage Receptors Lacking the Active-Site Glutamine"
<p>This .xlsx file contains the experimental data underpinning the research reported in Dietler et al. (2022) "Signal Transduction in Light-Oxygen-Voltage Receptors Lacking the Active-Site Glutamine"</p>
Wikidata5m - knowledge graph (transductive)
<p>Wikidata5m is a million-scale knowledge graph dataset with aligned corpus.This dataset integrates the <a href="https://www.wikidata.org/">Wikidata</a> knowledge graph and <a href="https://www.wikipedia.org/">Wikipedia</a> pages. Each entity in Wikidata5m is described by a corresponding Wikipedia page, which enables the evaluation of link prediction over unseen entities.</p> <p>This file contains the transductive split of Wikidata5m knowledge graph.</p>
A custom-made AAV1 variant (AAV1-T593K) enables efficient transduction of Japanese quail neurons in vitro and in vivo
<p><span>The widespread use of rodents in neuroscience has prompted the development of optimized viral variants for transduction of brain cells, <em>in vivo</em>. However, many of the viruses developed are less efficient in other model organisms, with birds being among the most resistant to transduction by current viral tools. Resultantly, the use of genetically-encoded tools and methods in avian species is markedly lower than in rodents; likely holding the field back. We sought to bridge this gap by developing custom viruses towards the transduction of brain cells of the Japanese quail. We first develop a protocol for culturing primary neurons and glia from quail embryos, followed by characterization of cultures via immunostaining, single-cell mRNA sequencing, patch clamp electrophysiology and calcium imaging. We then leverage the cultures for the rapid screening of various viruses, only to find that all yielded poor to no infection of cells <em>in vitro</em>. However, few infected neurons were obtained by AAV1 and AAV2. Scrutiny of the sequence of the AAV receptor found in quails led us to rationally design a custom-made AAV variant (AAV1-T593K; AAV1*) that exhibits improved transduction efficiencies <em>in vitro</em> and <em>in vivo</em> (eight- and five-fold, respectively). Together, we present a unique culturing method, transcriptomic profiles of quail's brain cells and a custom-tailored AAV1 for transduction of quail neurons <em>in vitro </em>and<em> in vivo.</em></span></p>
MND-ADA Transduction of CD34+ Cells From Children With ADA-SCID
ClinicalTrials.gov study NCT00794508. IPD Sharing: NO. Countries: 1. Publications: 4.
A custom-made AAV1 variant (AAV1-T593K) enables efficient transduction of Japanese quail neurons in vitro and in vivo
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Data from: Limits on information transduction through amplitude and frequency regulation of transcription factor activity
Signaling pathways often transmit multiple signals through a single shared transcription factor (TF) and encode signal information by differentially regulating TF dynamics. However, signal information will be lost unless it can be reliably decoded by downstream genes. To understand the limits on dynamic information transduction, we apply information theory to quantify how much gene expression information the yeast TF Msn2 can transduce to target genes in the amplitude or frequency of its activation dynamics. We find that although the amount of information transmitted by Msn2 to single target genes is limited, information transduction can be increased by modulating promoter cis-elements or by integrating information from multiple genes. By correcting for extrinsic noise, we estimate an upper bound on information transduction. Overall, we find that information transduction through amplitude and frequency regulation of Msn2 is limited to error-free transduction of signal identity, but not signal intensity information.
Tunable force transduction through the Escherichia coli cell envelope
<p>Killing Assays, SDS Assays, Microscopy profiles and segmented cells (.res files for MicrobeJ).</p>
Phage-host co-evolution has led to distinct generalized transduction strategies
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Data and code for the article "Superconducting qubit readout via low-backaction electro-optic transduction"
<p>Data set for the manuscript "Superconducting qubit readout via low-backaction electro-optic transduction", which will appear in Nature. </p>
ScienceDex guides
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.