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Dataset results
33 results for “Tumor angiogenesis”
Raw Data for the article: Potential Anti-Metastatic Role of the Novel miR-CT3 in Tumor Angiogenesis and Osteosarcoma Invasion
<p>Osteosarcoma (OS) is the most common primary bone tumor mainly occurring in young adults and derived from primitive bone-forming mesenchyme. OS develops in an intricate tumor microenvironment (TME) where cellular function regulated by microRNAs (miRNAs) may affect communication between OS cells and the surrounding TME. Therefore, miRNAs are considered potential therapeutic targets in cancer and one of the goals of research is to accurately define a specific signature of a miRNAs, which could reflect the phenotype of a particular tumor, such as OS. Through NGS approach, we previously found a specific molecular profile of miRNAs in OS and discovered 8 novel miRNAs. Among these, we deepen our knowledge on the fifth candidate renamed now miR-CT3. MiR-CT3 expression was low in OS cells when compared with human primary osteoblasts and healthy bone. Through TargetScan, VEGF-A was predicted as a potential biological target of miR-CT3 and luciferase assay confirmed it. We showed that enforced expression of miR-CT3 in two OS cell lines, SAOS-2 and MG-63, reduced expression of VEGF-A mRNA and protein, inhibiting tumor angiogenesis. Enforced expression of miR-CT3 also reduced OS cell migration and invasion as confirmed by soft agar colony formation assay. Interestingly, we found that miR-CT3 behaves inducing the activation of p38 MAP kinase pathway and modulating the epithelial-mesenchymal transition (EMT) proteins, in particular reducing Vimentin expression. Overall, our study highlights the novel role of miR-CT3 in regulating tumor angiogenesis and progression in OS cells, linking also to the modulation of EMT proteins.</p>
Inflammatory Breast Cancer, Tumor Markers, and Factors Associated With Angiogenesis
ClinicalTrials.gov study NCT00646555. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Drivers of Hypoxia-induced Angiogenesis in Tumor Development
ClinicalTrials.gov study NCT03979833. IPD Sharing: UNDECIDED. Countries: 1. Publications: 17.
Study of Apatinib as an Inhibitor of Tumor Angiogenesis
ClinicalTrials.gov study NCT00633490. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Global transcriptional analysis identifies a novel role for SOX4 in tumor-induced angiogenesis
GEO Series GSE99256. Homo sapiens. 11 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Role of mucin MUC5AC on tumor angiogenesis and lung adenocarcinoma development
GEO Series GSE290456. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Apigenin inhibits tumor angiogenesis by suppressing microvesicle biogenesis
GEO Series GSE251817. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Stress-induced ADGRL4 orchestrates tumor dormancy and relapse via Gαs-YAP1 signaling and angiogenesis
GEO Series GSE311934. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Identification of a Novel Angiogenesis and Tumor Suppressor Gene Rab25 in Esophageal Squamous Cell Carcinoma
GEO Series GSE32424. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
MicroRNA-214 downregulation contributes to tumor angiogenesis via inducing secretion of hepatoma-derived growth factor in human hepatoma
GEO Series GSE36915. Homo sapiens. 89 samples. Type: Non-coding RNA profiling by array.
Tumor cell endogenous HIF-1alpha activity induces aberrant angiogenesis and interacts with TRAF6 pathway required for colorectal cancer development
GEO Series GSE155104. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
miR-126-3p contributes to parathyroid tumor angiogenesis
<p>Tumors of the parathyroid glands are highly vascularized and display a microRNA (miRNA) profile divergent from normal parathyroid glands (PaNs). Angiogenic miRNAs, namely miR-126-3p, miR-126-5p, and miR-296-5p, have been found downregulated in parathyroid tumors. Here, we show that miR-126-3p expression levels are reduced in parathyroid adenomas (PAds; n = 12) compared with PaNs (n = 4). In situ hybridization (ISH) of miR-126-3p and miR-296-5p in 10 PAds show that miR-126-3p is expressed by endothelial cells lining the walls of great vessels and by cells within the thin stroma surrounding acinar structures. At variance, miR-296-5p was detectable in most PAd epithelial cells. Combining ISH for miR-126-3p with immunohistochemistry for the endothelial and mesenchymal markers CD34, CD31 and α-smooth muscle actin (αSMA), we could identify that miR-126-3p is localized in the αSMA-positive thin stroma. Further, miR-126-3p-expressing cells are enriched in the CD34-positive stromal cells surrounding epithelial cell acinar structures, a cellular pattern consistent with tumor-associated myofibroblasts (TAMs). In line with this, CD34-positive cells, sorted by FACS from PAds tissues, express miR-126-3p at higher levels than CD34-negative cells, suggesting that miR-126-3p downregulation promotes the endothelial-to-αSMA+ mesenchymal transition. In human mesenchymal stem cells derived from bone marrow (hBM-MSCs), a model of TAMs, the co-culture with PAds-derived cells for 5 days decreases miR-126-3p, while it increases VEGFA expression. At variance, adrenomedullin (ADM) expression is unaffected. Finally, overexpression of the miR-126-3p mimic in both hBM-MSCs and PAds-derived explants downregulates VEGFA expression levels. In conclusion, miR-126-3p is expressed by both endothelial cells and TAMs in PAds, and its downregulation promotes neoangiogenesis, possibly through VEGFA overexpression.</p>
PET/CT Imaging of Angiogenesis in Patients With Neuroendocrine Tumors Using 68Ga-NODAGA-E[c(RGDyK)]2
ClinicalTrials.gov study NCT03271281. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study of DNA Damage, Angiogenesis, and PD-L1 Inhibitors in Advanced Solid Tumors
ClinicalTrials.gov study NCT03851614. IPD Sharing: NO. Countries: 1. Publications: 0.
The Correlation Between Tumor Angiogenesis and the Effect of Radiation Therapy in Cervical Cancer Patients
ClinicalTrials.gov study NCT00155077. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Quantitation of Endothelial Progenitor Cells as Markers of Tumor Angiogenesis in Breast Cancer
ClinicalTrials.gov study NCT00393341. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Studying Cerebrospinal Fluid Proteins and Angiogenesis Proteins in Young Patients With Newly Diagnosed Central Nervous System Tumors
ClinicalTrials.gov study NCT00897858. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Phase I Trial: 68Ga-NODAGA-E(c[RGDyK])2 Positron Emission Tomography for Imaging Angiogenesis in Primary and Metastatic Tumor Lesions in Humans
ClinicalTrials.gov study NCT02970786. IPD Sharing: NO. Countries: 1. Publications: 0.
A novel action mechanism for MPT0G013, a derivative of arylsulfonamide, inhibits tumor angiogenesis through up-regulaiton of TIMP3 expression
GEO Series GSE56927. Homo sapiens. 2 samples. Type: Expression profiling by array.
Inhibition of PAK2 in endothelial cells suppresses tumor angiogenesis and promotes immune sensitization through CXCL10
GEO Series GSE312096. Mus musculus; Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.