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114 results for “Tumor suppressor genes”
A cohort-based study of host gene expression: tumor suppressor and innate immune/inflammatory pathways associated with the HIV reservoir size
<p>The major barrier to an HIV cure is the HIV reservoir: latently-infected cells that persist despite effective antiretroviral therapy (ART). Most prior studies of host genetic predictors of HIV control have focused on "elite controllers," rare individuals able to control virus in the absence of ART. However, there have been few genetic studies among ART-suppressed non-controllers, who make up the majority of people living with HIV (PLWH). We performed host RNA sequencing and HIV reservoir quantification (total DNA [tDNA], unspliced RNA [usRNA], intact DNA) from peripheral CD4+ T cells from 191 HIV+ ART-suppressed non-controllers. After adjusting for nadir CD4+ count, timing of ART initiation, and genetic ancestry, we identified two host genes for which higher expression was significantly associated with smaller total DNA viral reservoir size, <em>P3H3</em> and <em>NBL1</em>, both known tumor suppressor genes. We then identified 17 host genes for which lower expression was associated with higher residual transcription (HIV usRNA). These included novel associations with membrane channel (<em>KCNJ2</em>, <em>GJB2</em>), inflammasome (<em>IL1A, CSF3, TNFAIP5, TNFAIP6, TNFAIP9, CXCL3, CXCL10</em>), and innate immunity (TLR7) genes (FDR-adjusted q<0.05). Gene set enrichment analyses further identified significant associations of HIV usRNA with TLR4/microbial translocation (q=0.006), IL-1/NRLP3 inflammasome (q=0.008), and IL-10 (q=0.037) signaling. Protein validation assays using ELISA and multiplex cytokine assays supported these observed inverse host gene correlations, with P3H3, IL-10, and TNF-a protein associations achieving statistical significance (p<0.05). Of note, plasma IL-10 was also significantly inversely associated with HIV DNA (p=0.016). HIV intact DNA was not associated with differential host gene expression, although this may have been due to a large number of undetectable values in our study. Further data are needed to validate these findings, including functional genomic studies, larger cohorts including underrepresented PLWH in research, and those including dedicated assays to measure the replication-competent HIV reservoir.</p>
A cohort-based study of host gene expression: tumor suppressor and innate immune/inflammatory pathways associated with the HIV reservoir size
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Small extrachromosomal circular DNA harboring targeted tumor suppressor gene mutations supports intratumor heterogeneity in mouse liver cancer induced by multiplexed CRISPR/Cas9
<p>These files include raw image data from our study titled "Small extrachromosomal circular DNA containing targeted tumor suppressor mutations supports intratumoral heterogeneity in multiplex CRISPR/Cas9-induced mouse liver cancer".</p>
Registry for Patients With Wilms' Tumor Suppressor Gene 1 (WT1) Mutation Associated Diseases
ClinicalTrials.gov study NCT01252901. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Prognostic Value of Androgen Receptor Expression and Mutations Within Oncogenes and Tumor Suppressor Genes in Patients Treated for High Risk Prostate Cancer With Proton Therapy (PRX32)
ClinicalTrials.gov study NCT03296124. IPD Sharing: NO. Countries: 1. Publications: 17.
Almonertinib Plus Chemotherapy as First-line Treatment in Patients With EGFR Concomitant Tumor Suppressor Gene Mutation
ClinicalTrials.gov study NCT04500717. IPD Sharing: NO. Countries: 1. Publications: 0.
Using Probiotics to Reactivate Tumor Suppressor Genes in Colon Cancer
ClinicalTrials.gov study NCT03072641. IPD Sharing: NO. Countries: 0. Publications: 3.
Widespread intronic polyadenylation inactivates tumor suppressor genes in leukemia
GEO Series GSE111793. Homo sapiens. 28 samples. Type: Expression profiling by high throughput sequencing; Other.
Transcriptomic Alterations in Lung Adenocarcinoma Unveil New Mechanisms Targeted by the TBX2 Subfamily of Tumor Suppressor Genes
GEO Series GSE123769. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Non-Cell-Autonomous Tumor Suppressor Activity of the Homeobox Gene Cdx2 in the Gut
GEO Series GSE89992. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
AKR1B1 is required for maintaining acute leukemia cell survival by epigenetic silencing of tumor suppressor genes
GEO Series GSE275641. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Alternative poladenylation of tumor suppressor genes in small intestinal neuroendocrine tumors
GEO Series GSE56657. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Runx1 is a tumor suppressor gene in the mouse gastrointestinal tract
GEO Series GSE34292. Mus musculus. 8 samples. Type: Expression profiling by array.
Gene Expression Profile of high grade glioma in Nestin-creERT2 and NG2-creERTM driven tumor suppressors knockout mouse model
GEO Series GSE57038. Mus musculus. 13 samples. Type: Expression profiling by array.
Patterns of somatic uniparental disomy identify novel tumor suppressor genes in colorectal cancer
GEO Series GSE64112. Homo sapiens. 58 samples. Type: Methylation profiling by array.
Genomic loss of the putative tumor suppressor gene E2A promotes cutaneous T-cell lymphoma in human
GEO Series GSE21731. Homo sapiens. 42 samples. Type: Expression profiling by array; Genome variation profiling by genome tiling array.
Patterns of somatic uniparental disomy identify novel tumor suppressor genes in colorectal cancer
GEO Series GSE64114. Homo sapiens. 148 samples. Type: SNP genotyping by SNP array; Genome variation profiling by SNP array; Methylation profiling by array.
Role of SMAR1 in global gene regulation through interaction with tumor suppressor p53
GEO Series GSE70058. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Human umbilical cord matrix mesenchymal stem cells suppress the growth of breast cancer by expression of tumor suppressor genes [rat]
GEO Series GSE64838. Rattus norvegicus. 6 samples. Type: Expression profiling by array.
Adenovirus Small E1A Employs the Lysine Acetylases p300/CBP and Tumor Suppressor Rb to Repress Select Host Genes and Promote Productive Virus Infection [H3k27ac_ChIP]
GEO Series GSE59680. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.