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526 results for “Vestibular”
Text-fig. 6. Metacheiromys marshi, AMNH 131777, left petrosal isosurface from CT scans in endocranial view. a – shaded drawing; b – line drawing with labels. Abbreviations: app – apex partis petrosae, cc – cochlear canaliculus, crp – crista petrosa, cs – cerebral surface, iam – internal acoustic meatus, lji – lateral jugular incisure, me – mastoid exposure, mji – medial jugular incisure, saf – subarcuate fossa, sips – sulcus for inferior petrosal sinus, soev – sulcus for occipital emissary vein, sss – sulcus for sigmoid sinus, tc – transverse crest, to ptc – to posttemporal canal, va – vestibular aqueduct. in Skeletal Anatomy Of The Basicranium And Auditory Region In The Metacheiromyid Palaeanodont Metacheiromys (Mammalia, Pholidotamorpha) Based On High-Resolution Ct Scans
Text-fig. 6. Metacheiromys marshi, AMNH 131777, left petrosal isosurface from CT scans in endocranial view. a – shaded drawing; b – line drawing with labels. Abbreviations: app – apex partis petrosae, cc – cochlear canaliculus, crp – crista petrosa, cs – cerebral surface, iam – internal acoustic meatus, lji – lateral jugular incisure, me – mastoid exposure, mji – medial jugular incisure, saf – subarcuate fossa, sips – sulcus for inferior petrosal sinus, soev – sulcus for occipital emissary vein, sss – sulcus for sigmoid sinus, tc – transverse crest, to ptc – to posttemporal canal, va – vestibular aqueduct.
Identification of immune-related candidate biomarkers in plasma of patients with sporadic vestibular schwannoma
<p>Vestibular schwannoma (VS) is an intracranial tumor arising from neoplastic Schwann cells, and typically presenting with hearing loss. The traditional belief that hearing deficit is caused by physical expansion of the VS, compressing the auditory nerve, does not explain the common clinical finding that patients with small tumors can have profound hearing loss, suggesting that tumor-secreted factors could influence hearing ability in VS patients. We conducted profiling of patients' plasma for 66 immune-related factors in patients with sporadic VS (N>170) and identified and validated candidate biomarkers associated with tumor size (S100B) and hearing (MCP-3). We further identified a 9-biomarker panel (TNR-R2, MIF, CD30, MCP-3, IL-2R, BLC, TWEAK, eotaxin, S100B) with outstanding discriminatory ability for VS. These findings revealed possible therapeutic targets for VS, providing a unique diagnostic tool that may predict hearing change and tumor growth in VS patients, and may inform the timing of tumor resection to preserve hearing.</p>
Data from: To hatch and hatch not: Rejecting the hypothesis that heterochrony in vestibular mechanosensing explains poor escape-hatching success of Agalychnis spurrelli in snake attacks compared with its congener A. callidryas
<p>Phyllomedusid treefrogs hatch prematurely to escape egg predation, but escape success varies among species. During spontaneous hatching of <em>Agalychnis</em> <em>spurrelli</em>, snake attacks elicited 55% less escape-hatching than did attacks on less developed <em>A. callidryas</em>. <em>Agalychnis</em> <em>callidryas</em> use their vestibular system and, secondarily, their lateral line to sense physical disturbances that cue hatching. Since <em>A. spurrelli </em>develop faster, we hypothesized that heterochronic shifts in the onset timing of vestibular mechanosensory function, relative to hatching ability, might explain their lower escape response to mechanosensory cues. To test this, we compared the onset timing of hypoxia- and mechanosensory-cued hatching (MCH) and vestibular mechanosensory function in developmental series of <em>A. spurrelli</em> and <em>A. callidryas</em> embryos. Across species, most sibships began responding to each cue at the same developmental stage. MCH onset in A. spurrelli was associated with vestibular function onset, as indicated by measurements of the vestibulo-ocular reflex (VOR). Indeed, the first <em>A. spurrelli</em> embryos to show MCH had VOR amplitudes similar to those previously found for <em>A. callidryas</em> at the onset of MCH. These results indicate that low escape-hatching success in <em>A. spurrelli</em> is not caused by a relative delay in the onset of vestibular mechanosensory function, rejecting our initial hypothesis; the developmental timing of vestibular mechanosensing and its role in predator-induced hatching appears conserved. Our observations of both higher escape success of larger clutches in snake attacks and hatching complications in flooded A. spurrelli suggest, instead, that differences in egg capsule and clutch structure may contribute to species differences in escape-hatching success.</p>
The potassium channel subunit Kv1.8 (Kcna10) is essential for the distinctive outwardly rectifying conductances of type I and II vestibular hair cells
<p>In amniotes, head motions and tilt are detected by two types of vestibular hair cells (HCs) with strikingly different morphology and physiology. Mature type I HCs express a large and very unusual potassium conductance, g<sub>K,L</sub>, which activates negative to resting potential, confers very negative resting potentials and low input resistances, and enhances an unusual non-quantal transmission from type I cells onto their calyceal afferent terminals. Following clues pointing to K<sub>V</sub>1.8 (KCNA10) in the Shaker K channel family as a candidate g<sub>K,L</sub> subunit, we compared whole-cell voltage-dependent currents from utricular hair cells of K<sub>V</sub>1.8-null mice and littermate controls. We found that K<sub>V</sub>1.8 is necessary not just for g<sub>K,L</sub> but also for fast-inactivating and delayed rectifier currents in type II HCs, which activate positive to resting potential. The distinct properties of the three K<sub>V</sub>1.8-dependent conductances may reflect different mixing with other K<sub>V</sub>1 subunits, such as K<sub>V</sub>1.4 (KCNA4). In K<sub>V</sub>1.8-null HCs of both types, residual outwardly rectifying conductances include K<sub>V</sub>7 (KCNQ) channels. </p> <p>Current clamp records show that in both HC types, K<sub>V</sub>1.8-dependent conductances increase the speed and damping of voltage responses. Features that speed up vestibular receptor potentials and non-quantal afferent transmission may have helped stabilize locomotion as tetrapods moved from water to land.</p>
Discovering cryptic pocket opening and binding of a stimulant derivative in a vestibular site of the 5-HT3A receptor
<p>Raw MD simulation data of 4-Bromoamphetamine-5HT3A complex in two different forceeild, AMBER and CHARMM.</p> <p>Original paper title: "Discovering cryptic pocket opening and binding of a stimulant derivative in a vestibular site of the 5-HT3A receptor"</p> <p>Author list: <span>Nandan Haloi</span><span>,</span> <span>Emelia Karlsson</span><span>,</span> <span>Marc Delarue, </span><span>Rebecca J. Howard</span><span>,</span> <span>Erik Lindahl</span></p>
Datasets for Multimodal Biosensing for Vestibular Network-Based Cybersickness Detection
<p>These are the datasets about the experimental group (N=20, where N is the sample size, that is, 20 participants in total) and control group (N=20, where N is the sample size, that is, 20 participants in total) for our published paper entitled "Multimodal Biosensing for Vestibular Network-Based Cybersickness Detection", DOI: 10.1109/JBHI.2021.3134024. </p> <p>1. What do these datasets include?</p> <p>There are 40 participants' data in 40 folders, respectively. Each folder includes EEG data, Questionnaires, and answers as well as other non-EEG biometrics and memory test result of the cognitive task.</p> <p><br> 1.1 EEG data<br> All EEG data is either *.easy file or *.info file. The *.easy file is the raw EEG data. The *.info file is the information (e.g., EEG montage) paired with those raw EEG data. The *.info file can be simply readable by any Notepad software. The *.easy file can be readable by Neuroelectrics's plugin for EEGLAB (https://www.neuroelectrics.com/wiki/index.php/EEGLAB). Note, most of the participants' EEG data is a single easy file, but due to technical problems, few participants' EEG data consists of some separated easy files. Please use the function 'merge dataset' in the EEGLAB to merge them, and then use the following markers to extract segments of interest.</p> <p>All received EEG markers are integer numbers. Specifically, the markers are as follows:</p> <p>For control group:<br> a) The 'target' stimuli in the cognitive task: 16<br> b) The 'distractor' stimuli in cognitive task:32<br> c) The end of Baseline_1(that is, before the first cognitive task): 37<br> d) The end of Baseline_2(that is, before the round 1 neutral task): 47<br> e) The end of Baseline_3(that is, before the round 2 neutral task): 57<br> f) The end of Baseline_4(that is, before the second cognitive task): 67<br> g) The end of FMS reporting during the round 1 neutral task: 100<br> h) The end of FMS reporting during the round 2 neutral task: 101</p> <p>For experimental group:</p> <p>a) The 'target' stimuli in the cognitive task: 16<br> b) The 'distractor' stimuli in cognitive task:32<br> c) The end of Baseline_1(that is, before the first cognitive task): 37<br> d) The end of Baseline_2(that is, before the tunnel travel task): 47<br> e) The end of Baseline_3(that is, before the rollercoaster task): 57<br> f) The end of Baseline_4(that is, before the second cognitive task): 67<br> g) The end of FMS reporting during the Tunnel travel task: 100<br> h) The end of FMS reporting during the Rollercoaster task: 101</p> <p>1.2 Questionnaires</p> <p>1.2.1 SSQ<br> All SSQ questionnaires are named as xxx_QuestionnaireResult.csv, where xxx stands for the timestamps.</p> <p>1.2.2 FMS</p> <p>For control group:<br> All FMS questionnaires are named as xxx_Nature_FMS_backup.csv or xxx_Bio-data and FMS Nature.csv, where xxx stands for the timestamps and 'Nature' refers to the vection-free neutral task. The FMS scores in the xxx_FMS_backup.csv and xxx_Bio-data and FMS 'Task name'.csv are the exactly same. Unlike the xxx_Bio-data and FMS 'Task name'.csv contains the non-EEG biometrics as well, the xxx_FMS_backup.csv is pure FMS scores and easy to read.</p> <p>For experimental group:</p> <p>All FMS questionnaires are named as xxx_Gabor_FMS_backup.csv or xxx_Rollercoaster_FMS_backup.csv or xxx_Bio-data and FMS GaborRacer.csv or xxx_Bio-data and FMS Rollercoaster.csv, where xxx stands for the timestamps and Gabor or GaborRacer refer to the tunnel travel task. The FMS scores in the xxx_FMS_backup.csv and xxx_Bio-data and FMS 'Task name'.csv are the exactly same. Unlike the xxx_Bio-data and FMS 'Task name'.csv contains the non-EEG biometrics as well, the xxx_FMS_backup.csv is pure FMS scores and easy to read.</p> <p>1.3 Non-EEG biometrics<br> All non-EEG biometrics are named as xxx_Bio-data 'Task name'.csv, where 'Task name' refers to 'VA' (that is the cognitive task), or 'Nature' (for the control group) or 'GaborRacer' (for the experimental group) or 'Rollercoaster' (for the experimental group). The column information is as follows:<br> Column A: time<br> Column Q: PPG raw data (the left index finger)<br> Column R: Fingertip temperature (the left middle finger)<br> Column S: Forehead temperature<br> Column T: VR hermetic space temperature</p> <p>The data in other columns are not used in this study.</p> <p>1.4 The memory test result of the cognitive task</p> <p>Memory test result: xxx_CheckMemoryResult.csv, where xxx stands for the timestamps.</p> <p>Column A: time</p> <p>Column B: memory test result (Correct/Wrong)</p> <p>Column C: the number of the target (green sunfish)</p> <p>Column D: the reported number of the target in the memory test</p>
Gaze-Stabilizing Central Vestibular Neurons Project Asymmetrically to Extraocular Motoneuron Pools
<p><strong>ABSTRACT </strong>Within reflex circuits, specific anatomical projections allow central neurons to relay sensations to effectors that generate movements. A major challenge is to relate anatomical features of central neural populations, such as asymmetric connectivity, to the computations the populations perform. To address this problem, we mapped the anatomy, modeled the function, and discovered a new behavioral role for a genetically defined population of central vestibular neurons in rhombomeres 5–7 of larval zebrafish. First, we found that neurons within this central population project preferentially to motoneurons that move the eyes downward. Concordantly, when the entire population of asymmetrically projecting neurons was stimulated collectively, only downward eye rotations were observed, demonstrating a functional correlate of the anatomical bias. When these neurons are ablated, fish failed to rotate their eyes following either nose-up or nose-down body tilts. This asymmetrically projecting central population thus participates in both upward and downward gaze stabilization. In addition to projecting to motoneurons, central vestibular neurons also receive direct sensory input from peripheral afferents. To infer whether asymmetric projections can facilitate sensory encoding or motor output, we modeled differentially projecting sets of central vestibular neurons. Whereas motor command strength was independent of projection allocation, asymmetric projections enabled more accurate representation of nose-up stimuli. The model shows how asymmetric connectivity could enhance the representation of imbalance during nose-up postures while preserving gaze stabilization performance. Finally, we found that central vestibular neurons were necessary for a vital behavior requiring maintenance of a nose-up posture: swim bladder inflation. These observations suggest that asymmetric connectivity in the vestibular system facilitates representation of ethologically relevant stimuli without compromising reflexive behavior.</p> <p><strong>SIGNIFICANCE STATEMENT</strong> Interneuron populations use specific anatomical projections to transform sensations into reflexive actions. Here we examined how the anatomical composition of a genetically defined population of balance interneurons in the larval zebrafish relates to the computations it performs. First, we found that the population of interneurons that stabilize gaze preferentially project to motoneurons that move the eyes downward. Next, we discovered through modeling that such projection patterns can enhance the encoding of nose-up sensations without compromising gaze stabilization. Finally, we found that loss of these interneurons impairs a vital behavior, swim bladder inflation, that relies on maintaining a nose-up posture. These observations suggest that anatomical specialization permits neural circuits to represent relevant features of the environment without compromising behavior.</p>
Synaptic encoding of vestibular sensation regulates movement timing and coordination
<p>HamlingSchoppik2021 <br> Data/Code Repository Notes</p> <p>Note: All code was written and tested on Matlab R2017b </p> <p>0) Uncompress the tar files as follows:<br> Code.tar.gz into HamlingSchoppik2021/Code/<br> Anatomy.tar.gz,Behavior.tar.gz,CCShake.tar.gz,EPSCShake.tar.gz,HypDep.tar.gz,IPSCShake.tar.gz,NefmaLesionBackfillControl.tar.gz,NefmaPAGFPComparison.tar.gz,RecordingProperties.tar.gz,SpontCC.tar.gz,SpontaneousEPSC.tar.gz,SpontaneousIPSC.tar.gz into HamlingSchoppik2021/ProcessedData/<br> LesionsDay1.tar.gz,LesionsDay2.tar.gz,NefmaControls.tar.gz,NefmaLesions.tar.gz,PA-GFPcontrols.tar.gz,PA-GFPlesion.tar.gz into /HamlingSchoppik2021/RawBehaviorData/</p> <p>LesionsDay1ByDate.tar.gz,LesionsDay2ByDate.tar.gz,NefmaControlsByDate.tar.gz,NefmaLesionsByDate.tar.gz,PA-GFPcontrolsByDate.tar.gz,PA-GFPlesionByDate.tar.gz into /HamlingSchoppik2021/RawBehaviorData_byExpt/<br> and<br> RawEphysData2015.tar.gz,RawEphysData2016.tar.gz,RawEphysData2017.tar.gz into /HamlingSchoppik2021/RawEphysData</p> <p>1) (on a mac) Add HamlingSchoppik2021 to the Desktop</p> <p>2) Add HamlingSchoppik2021 to Matlab path</p> <p>3) If starting from Raw Data (optional):<br> Run preprocessData.m to take process raw Ephys data and raw behavioral data. Processed ephys data will save in folders in /ProcessedData. Processed behavioral data will save in the RawBehaviorData folders. <br> Pull all Behavior folders from /RawBehaviorData and /RawBehaviorData_byExperiment into /ProcessedData/Behavior for further plotting. </p> <p>4) If starting from Processed Data (recommended):<br> Run code in /HamlingSchoppik2021/Code for each figure. These codes call functions from /Code/calledFunctions. <br> The code for each figure can be run independently (they do not need to be called in any order)<br> Each code makes figures for a main figure, calculates any stats that are in the text for that figure, and makes any supplementary figures associated with that figure. (With exception of Figure S1 which has its own code). </p>
Advances in Vestibular Rehabilitation
ClinicalTrials.gov study NCT04144686. IPD Sharing: NO. Countries: 1. Publications: 37.
Rizatriptan for Episodic Dizziness in Vestibular Migraine
ClinicalTrials.gov study NCT02447991. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Galcanezumab for Vestibular Migraine
ClinicalTrials.gov study NCT04417361. IPD Sharing: NO. Countries: 1. Publications: 11.
Virtual Environments for Vestibular Rehabilitation
ClinicalTrials.gov study NCT04268745. IPD Sharing: NO. Countries: 1. Publications: 2.
Vestibular Infant Screening - Rehabilitation
ClinicalTrials.gov study NCT06177132. IPD Sharing: YES. Countries: 1. Publications: 5.
Effects of Lifestyle Modification on Vestibular Migraine
ClinicalTrials.gov study NCT03979677. IPD Sharing: NO. Countries: 1. Publications: 1.
Individualized Vestibular Rehabilitation for Elderly With Self-Management and Gaming Elements
ClinicalTrials.gov study NCT05436067. IPD Sharing: YES. Countries: 1. Publications: 2.
Bevacizumab for Symptomatic Vestibular Schwannoma in Neurofibromatosis Type 2 (NF2)
ClinicalTrials.gov study NCT01207687. IPD Sharing: NO. Countries: 1. Publications: 1.
Interactive Rehabilitation for Adults With Unilateral Vestibular Weakness
ClinicalTrials.gov study NCT04875013. IPD Sharing: NO. Countries: 1. Publications: 4.
Vestibular Infants Screening-Flanders
ClinicalTrials.gov study NCT05061069. IPD Sharing: NO. Countries: 1. Publications: 4.
Vestibular Rehabilitation and Dizziness in Geriatric Patients
ClinicalTrials.gov study NCT00275392. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Vestibular Rehabilitation Protocol in Unilateral Vestibular Schwannoma
ClinicalTrials.gov study NCT07364955. IPD Sharing: YES. Countries: 1. Publications: 4.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.