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10 results for “Viral decay”
Data from: Exploring an alternative explanation for the second phase of viral decay: infection of short-lived cells in a drug-limited compartment during HAART
Most HIV-infected patients who initiate combination antiretroviral therapy experience a viral load decline in several phases. These phases are characterized by different rates of viral load decay that decrease when transitioning from one phase to the next. There is no consensus as to the origin of these phases. One hypothesis put forward is that short- and long-lived infected cells are responsible for the first and second phases of decay, respectively. However, significant differences in drug concentrations are observed in monocytes from various tissues, suggesting the first two phases of decay in viral loads could instead be attributed to short-lived cells being differently exposed to drugs. Compared to a well-exposed compartment, new cell infection can be expected in a compartment with limited drug exposure, thus leading to a slower viral load decay with potential virologic failure and drug resistance. In the current study, the latter hypothesis was investigated using a model of viral kinetics. Empirical datasets were involved in model elaboration and parameter estimation. In particular, susceptibility assay data was used for an in vitro to in vivo extrapolation based on the expected drug concentrations inside physiological compartments. Results from numerical experiments of the short-term evolution of viral loads can reproduce the first two phases of viral decay when allowing new short-lived cell infections in an unidentified drug-limited compartment. Model long-term predictions are however less consistent with clinical observations. For the hypothesis to hold, efavirenz, tenofovir and emtricitabine drug exposure in the drug-limited compartment would have to be very low compared to exposure in peripheral blood. This would lead to significant long-term viral growth and the frequent development of resistant strains, a prediction not supported by clinical observations. This suggests that the existence of a drug-limited anatomical compartment is unlikely, by itself, to explain the second phase of viral load decay.
Study of Viral Load Decay Rates in HIV Infected Participants Starting Treatment With Raltegravir (RAL) and Emtricitabine/Tenofovir Disoproxil Fumarate (TDF)
ClinicalTrials.gov study NCT00660972. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Data from: Exploring an alternative explanation for the second phase of viral decay: infection of short-lived cells in a drug-limited compartment during HAART
Open the record for dataset details and reuse information.
Fuzeon Viral Decay Pilot Study
ClinicalTrials.gov study NCT00334022. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Impact of CMV Status on HIV Viral Load Decay
ClinicalTrials.gov study NCT03349359. IPD Sharing: NO. Countries: 1. Publications: 0.
Integrase Inhibitor (MK-0518) Viral Decay
ClinicalTrials.gov study NCT00520897. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Cytoplasmic mRNA decay by the anti-viral nuclease RNase L promotes transcriptional repression [4sU-seq]
GEO Series GSE298174. Homo sapiens. 12 samples. Type: Other.
Cytoplasmic mRNA decay by the anti-viral nuclease RNase L promotes transcriptional repression [S5P Pol II CUT&Run]
GEO Series GSE298175. Homo sapiens. 15 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
RNA decay during gammaherpesvirus infection reduces RNA polymerase II occupancy of host promoters but spares viral promoters
GEO Series GSE132574. Mus musculus. 18 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Cytoplasmic mRNA decay by the anti-viral nuclease RNase L promotes transcriptional repression [S2P Pol II CUT&RUN]
GEO Series GSE313712. Homo sapiens. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
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