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Dataset results
12 results for “Viscoelastic Tests”
Safe Delivery of Thrombolytic Treatment for Pulmonary Embolism Using ClotPro® Viscoelastic Tests
ClinicalTrials.gov study NCT06667882. IPD Sharing: NO. Countries: 1. Publications: 8.
Use of Viscoelastic Tests in the Treatment of Traumatic Induced Coagulopathy: a Pragmatic Randomized Clinical Trial.
ClinicalTrials.gov study NCT03380767. IPD Sharing: NO. Countries: 1. Publications: 3.
Viscoelastic Testing Guided Tissue Plasminogen Activator Treatment in Acute Respiratory Failure
ClinicalTrials.gov study NCT05540834. IPD Sharing: NO. Countries: 1. Publications: 1.
Viscoelastic Tests-Guided Therapy In Liver Transplantation
ClinicalTrials.gov study NCT03756948. IPD Sharing: UNDECIDED. Countries: 0. Publications: 6.
Personalized ViscoElastic Testing-guided Bleeding Management In Liver Surgery, Neurosurgery and Obstetrics
ClinicalTrials.gov study NCT06635564. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Dataset for: Vibrometry as a noncontact alternative to dynamic and viscoelastic mechanical testing in cartilage
Open the record for dataset details and reuse information.
Predicting Platelet Count From Viscoelastic Testing
ClinicalTrials.gov study NCT06870851. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Novel Viscoelastic Test Based on Ultrasonic Guided Wave for Identifying Hyperfibrinolysis Rapidly
ClinicalTrials.gov study NCT06374953. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effects of Therapeutic Plasmaexhange on Viscoelastic Tests in Non-coagulopathic Patients
ClinicalTrials.gov study NCT04513249. IPD Sharing: NO. Countries: 1. Publications: 0.
Interpretability of the Quantra® Viscoelastic Test in Patients With Haematological Malignancies With Profound Thrombocytopenia Below 50x10 G/L.
ClinicalTrials.gov study NCT06455553. IPD Sharing: NO. Countries: 1. Publications: 0.
Viscoelastic Tests (VET) Versus Conventional Coagulation Tests (CCT) for Management of Trauma-Induced Coagulopathy
ClinicalTrials.gov study NCT06820879. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Are Viscoelastic Tests Clinically Useful to Identify Platelet-Dependent Bleeding in High-Risk Cardiac Surgery Patients?
<p>Baryshnikova E, Di Dedda U, Ranucci M. Are Viscoelastic Tests Clinically Useful to Identify Platelet-Dependent Bleeding in High-Risk Cardiac Surgery Patients? Anesth Analg. 2022 Dec 1;135(6):1198-1206. doi: 10.1213/ANE.0000000000006231. Epub 2022 Oct 13. PMID: 36227767.</p> <p>Abstract</p> <p><strong>Background: </strong>Postoperative use of platelet function testing to rule out microvascular bleeding due to platelet dysfunction after cardiac surgery still lacks strong reference data and reliable cutoff values, yielding a clinically adequate sensitivity and specificity. The present study aims to investigate the performance of two different point-of-care viscoelastic devices and platelet aggregometry in expressing surgery-dependent platelet dysfunction and anticipating postoperative major bleeding in a cohort of high-risk patients.</p> <p><strong>Methods: </strong>Prospective cohort study of 50 adult patients who were on antiplatelet drugs discontinued for no more than 7 days (clopidogrel and prasugrel) or 5 days (ticagrelor) undergoing cardiac surgery with cardiopulmonary bypass (CPB). Coagulation and platelet function testing, including QUANTRA, ROTEM, and Multiplate, were assessed preoperatively and postoperatively. Chest drain blood loss was measured in the first 12 postoperative hours. Perioperative bleeding was assessed using a modified version of the Universal Definition of Perioperative Bleeding (UDPB) in cardiac surgery, modified to not consider anemia-correcting packed red cells transfusions in the absence of bleeding >600 mL/12 h. Major bleeding was identified as UDPB class II or higher.</p> <p><strong>Results: </strong>Multiplate adenosine diphosphate (ADPtest) was significantly ( P = .001) reduced after CPB, whereas TRAPtest was not. The platelet component (PC) as extrapolated by ROTEM data (EXTEM MCF-FIBTEM MCF) was unchanged after CPB, while the A10 PC (PC at 10 minutes) was significantly ( P = .001) reduced. The QUANTRA platelet contribution to clot stiffness (PCS) was significantly ( P = .001) reduced, as well. At the ROC analysis for the predictive ability of the post-CPB platelet function testing, the best discrimination was obtained by the QUANTRA PCS, with an area under the curve (AUC) (95% confidence interval [CI]) of 0.80 (0.66-0.91), P = .001, followed by the ROTEM A10 PC with AUC (95% CI) of 0.75 (0.51-0.99), P = .004, and PC with AUC (95% CI) of 0.74 (0.50-0.99), P = .009. The Multiplate ADPtest had an AUC (95% CI) of 0.67 (0.42-0.91), and the TRAPtest had an AUC (95% CI) of 0.62 (0.37-0.86). The cutoff values identified were 13 hPa for the QUANTRA PCS, 40 mm for the ROTEM A10, and 48.5 mm for the ROTEM PC, with negative predictive values of 84%, 81%, and 86%, respectively, and positive predictive values of 55%, 53%, and 69%, respectively.</p> <p><strong>Conclusions: </strong>QUANTRA PCS, ROTEM A10 PC, and Multiplate ADPtest showed a significant decrease after CPB, whereas ROTEM PC and Multiplate TRAPtest did not. Major bleeding was predicted with a moderate to good discrimination by the post-CPB viscoelastic tests (PCS, PC, and A10 PC).</p>
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