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ShareScore release 0.9.0
Dataset results
36 results for “White matter disease”
Transcriptomic analyses of normal-appearing CNS white matter from multiple sclerosis donors reveal subtype-specific molecular signatures of disease (REVISED)
<p>Datasets of bulk RNA-sequencing of NAWM from MS donors + supplementary images of RNA deconvolution of cell trajectories</p>
Tractography Templates for White Matter Microstructure Analysis in Aging and Alzheimer's Disease
<p>This dataset contains tractography templates derived from several studies focused on white matter microstructure and its associations with neurodegenerative diseases, particularly Alzheimer's disease and Parkinsonism. These templates span key tracts relevant to both cognitive decline and motor function, including but not limited to the medial temporal lobe white matter, transcallosal fibers, sensorimotor tracts, and the fornix. The templates were developed and validated using advanced diffusion MRI techniques across various populations, including aging individuals, dementia patients, and those at risk of neurodegenerative conditions. This resource serves as a valuable tool for researchers investigating the structural integrity of white matter in both health and disease, allowing for cross-study comparability and enhancing the understanding of neurodegenerative processes.</p>
White matter hyperintensity maps in aging and neurodegenerative diseases
<div>The files contain voxel-wise white matter hyperintensity (WMH) maps for 11 different neurodegenerative disease cohorts from the <em>Canadian</em> Consortium on Neurodegeneration in Aging (<em>CCNA</em>) COMPASS-ND dataset in the MNI-ICBM152-2009c space.</div> <div> </div> <div>For more information regarding the participants and method details, see: </div> <div>Dadar, M., Mahmoud, S., Zhernovaia, M., Camicioli, R., Maranzano, J., Duchesne, S., & CCNA Group. (2022). White matter hyperintensity distribution differences in aging and neurodegenerative disease cohorts. <em>NeuroImage: Clinical</em>, <em>36</em>, 103204.</div>
The insidious degeneration of white matter and cognitive decline in Fabry disease
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Amyloid and Glucose PET Imaging in Alzheimer and Vascular Cognitive Impairment Patients With Significant White Matter Disease
ClinicalTrials.gov study NCT02330510. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Cognitive Changes in Alzheimer's Disease Patients Associated With or Without White Matter Changes After Rivastigmine
ClinicalTrials.gov study NCT01380288. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Evaluation of Brain Waste Clearance Pathways Using Magnetic Resonance Imaging in Pediatric Patients With White Matter Diseases
ClinicalTrials.gov study NCT06335004. IPD Sharing: UNDECIDED. Countries: 1. Publications: 6.
White Matter Hyperintensities Burden in Adult Patients With Cyanotic Congenital Heart Disease: a Pilot Study
ClinicalTrials.gov study NCT03487302. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: White matter alterations in Parkinson's disease with normal cognition precede grey matter atrophy
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Data from: White matter hyperintensities and CSF AD biomarkers in preclinical Alzheimer's disease
Objective: Recent studies suggest that white matter hyperintensities (WMH) on MRI, which primarily reflect small vessel cerebrovascular disease, may play a role in the evolution of Alzheimer's disease (AD). In a longitudinal study, we investigated whether WMH promote the progression of AD pathology, or alter the association between AD pathology and risk of progression from normal cognition to mild cognitive impairment (MCI). Methods: Two sets of analyses were conducted. The relationship between whole brain WMH load, based on FLAIR MRI images, obtained in initially cognitively normal participants (n=274) and time to onset of symptoms of MCI (n=60) was examined using Cox regression models. In a subset of the participants with both MRI and CSF data (n=204), the interaction of WMH load and CSF AD biomarkers was also evaluated. Results: Baseline WMH load interacted with CSF t-tau with respect to symptom onset, but not with CSF abeta1-42 or p-tau181. WMH volume was associated with time to symptom onset of MCI among individuals with low t-tau [HR=1.35, CI=1.06-1.73, p=0.013], but not those with high t-tau [HR=0.86,CI=0.56-1.32, p=0.47]. The rate of change in the CSF biomarkers over time was not associated with the rate of change in WMH volumes. Conclusions and Relevance: These results suggest that WMH primarily affect the risk of progression when CSF measures of neurodegeneration or neuronal injury (as reflected by t-tau) are low. However, CSF biomarkers of amyloid and p-tau and WMH appear to have largely independent and non-synergistic effects on the risk of progression to MCI.
Association of gyrification pattern, white matter changes and phenotypic profile in patients with Parkinson's disease
<p><b>Objective:</b> To investigate the cortical gyrification changes as well as their relationships with white matter (WM) microstructural abnormalities in the akinetic-rigid (AR) and tremor-dominant (TD) subtypes of Parkinson's disease (PD).</p> <p><b>Methods:</b> Sixty-four patients with the AR subtype, 26 patients with the TD subtype and 56 healthy controls (HCs) were included in this study. High-resolution T1-weighted and diffusion-weighted images were acquired for each participant. We computed local gyrification index (LGI) and fractional anisotropy (FA) to identify the cortical gyrification and WM microstructural changes in the AR and TD subtypes.</p> <p><b>Results: </b>Compared with HCs, patients with the AR subtype showed decreased LGI in the precentral, postcentral, inferior and superior parietal, middle and superior frontal/temporal, anterior and posterior cingulate, orbitofrontal, supramarginal, precuneus, and some visual cortices, and decreased FA in the corticospinal tract, inferior and superior longitudinal fasciculus, inferior fronto-occipital fasciculus, forceps minor/major, and anterior thalamic radiation. Decreases in LGI and FA of the AR subtype were found to be tightly coupled. LGIs of the left inferior and middle frontal gyrus correlated with the mini-mental state examination and the Hoehn and Yahr scores of patients with the AR subtype. Patients with the TD subtype showed no significant change in the LGI and FA compared with patients with the AR subtype and HCs.</p> <p><b>Conclusions:</b> Our results suggest that cortical gyrification changes in PD are motor phenotype-specific and are possibly mediated by the microstructural abnormalities of the underlying WM tracts.</p>
Data from: Enzyme replacement therapy and white matter hyperintensity progression in Fabry disease
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Data from: White matter hyperintensities and CSF AD biomarkers in preclinical Alzheimer’s disease
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Association of gyrification pattern, white matter changes and phenotypic profile in patients with Parkinson’s disease
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White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI
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Transcriptome analyses of the cortex and white matter of focal cortical dysplasia type II human samples: novel insights into disease mechanisms and contributions to tissue characterization
GEO Series GSE213488. Homo sapiens. 35 samples. Type: Expression profiling by high throughput sequencing.
Research Study for Single-Patient Treatment of Cree Leukoencephalopathy/Vanishing White Matter Disease
ClinicalTrials.gov study NCT07272525. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
MRS and DTI of White Matter in Alzheimer's Disease
ClinicalTrials.gov study NCT00172900. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Cerebrovascular Reserve and White Matter Disease in Patients with Chronic Anemia
ClinicalTrials.gov study NCT03715972. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Diffusion Magnetic Resonance Imaging (dMRI) in the Early Evaluation of Brain White Matter Diseases
ClinicalTrials.gov study NCT07108712. IPD Sharing: YES. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.