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20 results for “White matter hyperintensities”
White matter hyperintensity maps in aging and neurodegenerative diseases
<div>The files contain voxel-wise white matter hyperintensity (WMH) maps for 11 different neurodegenerative disease cohorts from the <em>Canadian</em> Consortium on Neurodegeneration in Aging (<em>CCNA</em>) COMPASS-ND dataset in the MNI-ICBM152-2009c space.</div> <div> </div> <div>For more information regarding the participants and method details, see: </div> <div>Dadar, M., Mahmoud, S., Zhernovaia, M., Camicioli, R., Maranzano, J., Duchesne, S., & CCNA Group. (2022). White matter hyperintensity distribution differences in aging and neurodegenerative disease cohorts. <em>NeuroImage: Clinical</em>, <em>36</em>, 103204.</div>
Data from: White matter hyperintensity load on stroke recurrence and mortality at 1 year after ischemic stroke
Objective: We set out to define the role and risks associated with white matter hyperintensity (WMH) load in a stroke population with respect to recurrent stroke and mortality after ischemic stroke. Methods: A total of 7,101 patients at a network of university hospitals presenting with ischemic strokes were followed for one year. Multivariable Cox proportional-hazards model and competing risk analysis were used to examine the independent association between quartiles of WMH load and stroke recurrence and mortality at one year. Results: Overall recurrent stroke risk at one year was 6.7%/yr, divided between 5.6%/yr for recurrent ischemic and 0.5%/yr for recurrent hemorrhagic strokes. There was a stronger association between WMH volume and recurrent hemorrhagic stroke by quartile (Hazard ratios [HR] of 7.32, 14.12, and 33.52, respectively) than for ischemic recurrence (HR of 1.03, 1.37, and 1.61, respectively), but the absolute incidence of ischemic recurrence by quartile was higher (3.8%/yr, 4.5%, 6.3%, and 8.2% by quartiles) versus hemorrhagic recurrence (0.1%/yr, 0.4%, 0.6%, and 1.3%). Mortality of all-cause (10.5%) showed a marked association with WMH volume (HR of 1.06, 1.46, and 1.60), but this was attributable to non-vascular, rather than vascular causes. Conclusions: There is an association between WMH volume load and stroke recurrence, and this association is stronger for hemorrhagic than for ischemic stroke, although the absolute risk of ischemic recurrence remains higher. This data should be helpful to practitioners seeking to find the optimal preventative/treatment regimen for post-stroke patients and to individualize risk-benefit ratios.
Periventricular White Matter Hyperintensities in Cerebral Amyloid Angiopathy and Hypertensive Arteriopathy
ClinicalTrials.gov study NCT05486897. IPD Sharing: Not stated. Countries: 1. Publications: 1.
WHIte MAtter Hyperintensity Shape and Glymphatics
ClinicalTrials.gov study NCT06010511. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Blood-Brain Barrier Disruption in People With White Matter Hyperintensities Who Have Had a Stroke
ClinicalTrials.gov study NCT03366129. IPD Sharing: Not stated. Countries: 1. Publications: 1.
White Matter Hyperintensities Burden in Adult Patients With Cyanotic Congenital Heart Disease: a Pilot Study
ClinicalTrials.gov study NCT03487302. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: White matter hyperintensity load on stroke recurrence and mortality at 1 year after ischemic stroke
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Data from: White matter hyperintensities and CSF AD biomarkers in preclinical Alzheimer's disease
Objective: Recent studies suggest that white matter hyperintensities (WMH) on MRI, which primarily reflect small vessel cerebrovascular disease, may play a role in the evolution of Alzheimer's disease (AD). In a longitudinal study, we investigated whether WMH promote the progression of AD pathology, or alter the association between AD pathology and risk of progression from normal cognition to mild cognitive impairment (MCI). Methods: Two sets of analyses were conducted. The relationship between whole brain WMH load, based on FLAIR MRI images, obtained in initially cognitively normal participants (n=274) and time to onset of symptoms of MCI (n=60) was examined using Cox regression models. In a subset of the participants with both MRI and CSF data (n=204), the interaction of WMH load and CSF AD biomarkers was also evaluated. Results: Baseline WMH load interacted with CSF t-tau with respect to symptom onset, but not with CSF abeta1-42 or p-tau181. WMH volume was associated with time to symptom onset of MCI among individuals with low t-tau [HR=1.35, CI=1.06-1.73, p=0.013], but not those with high t-tau [HR=0.86,CI=0.56-1.32, p=0.47]. The rate of change in the CSF biomarkers over time was not associated with the rate of change in WMH volumes. Conclusions and Relevance: These results suggest that WMH primarily affect the risk of progression when CSF measures of neurodegeneration or neuronal injury (as reflected by t-tau) are low. However, CSF biomarkers of amyloid and p-tau and WMH appear to have largely independent and non-synergistic effects on the risk of progression to MCI.
Data from: Enzyme replacement therapy and white matter hyperintensity progression in Fabry disease
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Data from: White matter hyperintensities and CSF AD biomarkers in preclinical Alzheimer’s disease
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Data from: Association of white matter hyperintensity markers on MRI and long-term risk of mortality and ischemic stroke: The SMART-MR study
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The Relationship Between White Matter Hyperintensity With Cognition and Emotion
ClinicalTrials.gov study NCT02761148. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Hyperbaric Oxygen Treatment in Patients With White Matter Hyperintensities
ClinicalTrials.gov study NCT00497432. IPD Sharing: Not stated. Countries: 1. Publications: 0.
White Matter Hyperintensities Subtypes in Cerebral Small Vessel Disease : 7 Tesla Ultra-high Resolution Imaging MRI
ClinicalTrials.gov study NCT04298866. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
White Matter Hyperintensities in Amnestic Mild Cognitive Impairment or Alzheimer's Disease
ClinicalTrials.gov study NCT06179680. IPD Sharing: NO. Countries: 1. Publications: 0.
A Study to Evaluate White Matter Hyperintensities in Migraine
ClinicalTrials.gov study NCT05112289. IPD Sharing: NO. Countries: 1. Publications: 0.
A Retrospective Study of the Relationship Between White Matter Hyperintensities(WMHs) Within the Cholinergic Pathways and the Cognition of PD Patients After Bilateral STN DBS
ClinicalTrials.gov study NCT02071693. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Cognitive Intervention in Mild Cognitive Impairment With or Without White Matter Hyperintensities
ClinicalTrials.gov study NCT03195803. IPD Sharing: NO. Countries: 0. Publications: 0.
A Computer-based Cognitive Stimulation in Mild Cognitive Impairment With White Matter Hyperintensities
ClinicalTrials.gov study NCT03195816. IPD Sharing: NO. Countries: 0. Publications: 0.
Diagnostic value and predictors of severity in circulating exosomal lncRNAs of white matter hyperintensities
GEO Series GSE200473. Homo sapiens. 11 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
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International Brain Laboratory public data
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OpenNeuro
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