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3 results for “Xenopus borealis”
Data for: New insights into Xenopus sex chromosome genomics from the Marsabit clawed frog, X. borealis
<p><span>In many groups, sex chromosomes change frequently but the drivers of their rapid evolution are varied and often poorly characterized. With an aim of further understanding sex chromosome turnover, we investigated the polymorphic sex chromosomes of the Marsabit clawed frog, <em>Xenopus borealis,</em> using genomic data and a new chromosome-scale genome assembly. We confirmed previous findings that 54.1 Mb of chromosome 8L is sex-linked in animals from east Kenya and a lab strain, but most (or all) of this region is not sex-linked in natural populations from west Kenya. Previous work suggests possible degeneration of the Z chromosomes in the east population because many sex-linked transcripts of this female heterogametic population have female-biased expression, and we therefore expected this chromosome to not be present in the west population. In contrast, our simulations support a model where the sex-linked portion of the Z chromosome from the east acquired autosomal segregation in the west, and where the W chromosome from the east was lost in the west. These recent changes are consistent with the hot potato model, wherein sex chromosome turnover is favoured by natural selection if it purges a (minimally) degenerate sex-specific sex chromosome, but counterintuitively suggest natural selection failed to purge a Z chromosome that has signs of more advanced and possibly more ancient regulatory degeneration. These findings highlight complex evolutionary dynamics of young, rapidly evolving <em>Xenopus</em> sex chromosomes, and set the stage for mechanistic work aimed at pinpointing additional sex-determining genes in this group.</span></p>
Data for: New insights into Xenopus sex chromosome genomics from the Marsabit clawed frog, X. borealis
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Genomic Analysis of genetically perturbed Xenopus Borealis embryos
GEO Series GSE250217. Xenopus borealis. 18 samples. Type: Expression profiling by high throughput sequencing.
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