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499 results for “YAPS”
Inhibition of epithelial cell YAP-TEAD/LOX signaling attenuates pulmonary fibrosis "
<table> <tbody> <tr> <td> <p>Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal disease characterized by excessive extracellular matrix (ECM) deposition. Current IPF therapies slow disease progression but do not stop or reverse it. The (myo)fibroblasts are thought to be the main cellular contributors to excessive ECM production in IPF. Here we report that fibrotic AT2 cells regulate production and crosslinking of ECM via the co-transcriptional activator YAP. YAP leads to increase expression of Lysyloxidase (LOX) and subsequent LOX mediated crosslinking by fibrotic AT2 cells. Pharmacological YAP inhibition reverses fibrotic AT2 cell reprogramming and LOX expression in experimental lung fibrosis <span>in vivo</span><span> and in human fibrotic </span><span>tissue ex vivo</span><span>. We thus identify YAP-TEAD/LOX inhibition in AT2 cells as a promising potential new therapy for IPF patients.<span> </span></span></p> <p><span><span>In</span></span></p> </td> </tr> </tbody> </table>
Figure 3 in A new species of Phyllium (Phyllium) Illiger (Phasmida: Phylliidae) from Yap Island, Micronesia, representing a range expansion for the family
Figure 3. Holotype of Phyllium (Phyllium) yapicum new species. A) Genitalia, ventral view. B) Antennae and anterior half of head. C) Left profemora.
Data from: Population genetic structure between Yap and Palau for the coral Acropora hyacinthus
Information on connectivity is becoming increasingly in demand as marine protected areas are being designed as an integral part of a network to protect marine resources at the ecosystem level. Larval dispersal and population structure, however, remain very difficult to assess. Here, we tested the predictions of a detailed oceanographic connectivity model of larval dispersal and coral recruitment within Palau and between Palau and Yap, which was developed to support the review of the existing network of marine protected areas in Palau. We used high throughput microsatellite genotyping of the coral Acropora hyacinthus to characterize population genetic structure. Pairwise F′ST values between Palau and Yap (0.10), Palau and Ngulu (0.09) and Yap and Ngulu (0.09) were all significant and similar to pairwise F′ST values of sites within Palau (0.02–0.12) and within Yap (0.02–0.09) highlighting structure at island scale and indicating that recruitment may be even more localized than previously anticipated. A bottleneck test did not reveal any signs of a founder effect between Yap and Palau. Overall, the data supports the idea that recovery of A. hyacinthus in Palau did not come exclusively from a single source but most likely came from a combination of areas, including sites within Palau. In light of these results there seems to be very little connectivity around the barrier reef and management recommendation would be to increase the number or the size of MPAs within Palau.
TS and tracer data for Yap−Mariana Junction
<p>A multi-tracer study at the Yap-Mariana Junction in the western Pacific was conducted using 85Kr, 39Ar and 14C. This dataset includes the T-S data and the tracer data. This dataset is the supporting material of a paper submitted to JGR Ocean entitled "Estimation of the ventilation transit time distribution at the Yap−Mariana Junction using 39Ar, 85Kr and 14C tracers".</p>
Data from: Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling
<p>The transcription factor TEAD, together with its coactivator YAP/TAZ, is a key transcriptional modulator of the Hippo pathway. Activation of TEAD transcription by YAP has been implicated in a number of malignancies, and this complex represents a promising target for drug discovery. Here, we employed covalent fragment screening approach followed by structure-based design to develop an irreversible TEAD inhibitor MYF-03-69. Using a range of <em>in vitro</em> and cell-based assays we demonstrated that through a covalent binding with TEAD palmitate pocket, MYF-03-69 disrupts YAP-TEAD association, suppresses TEAD transcriptional activity and inhibits cell growth of Hippo signaling defective malignant pleural mesothelioma (MPM). Further, a cell viability screening with a panel of 903 cancer cell lines indicated a high correlation between TEAD-YAP dependency and the sensitivity to MYF-03-69.</p> <p>To validate MYF-03-69 as potent and selective pan-TEAD inhibitor, we interrogated the proteome-wide selectivity profile of MYF-03-69 on cysteine labeling using a streamlined cysteine activity-based protein profiling (SLC-ABPP) approach and generated the spreadsheet "Supplementary_Dataset_1._Proteome-wide_selectivity_profile_of_MYF-03-69_on_cysteines_labeling_using_SLC-ABPP_approach". We employed the cysteine reactive desthiobiotin iodoacetamide (DBIA) probe which was reported to map more than 8,000 cysteines and performed a competition study on NCI-H226 cells pretreated with 0.5, 2, 10 or 25 µM of MYF-03-69 for 3 hours in triplicate. The cysteines that were conjugated >50% (competition ratio CR>2) compared to DMSO control were analyzed and assigned to the protein targets. In the DMSO control group, although DBIA mapped 12,498 cysteines in total, the TEAD PBP cysteines were not detected. This might be due to low TEAD1-4 protein abundance and/or inability of the PBP cysteines to be labeled given that they are mostly modified by palmitate under physiological conditions. Among 12,498 mapped cysteines, only 7 cysteines were significantly labeled (i.e. exhibited >50% conjugation or CR>2) by 25 µM of MYF-03-69, and all of these sites exhibited dose-dependent engagement.</p> <p>To study the whole transcriptome perturbation by TEAD inhibitor MYF-03-69, mRNA sequencing was performed in NCI-H226 cells that were treated with 0.1 μM, 0.5 μM, and 2 μM of MYF-03-69 and generated the spreadsheet "Supplementary_Dataset_2._List_of_differentially_expressed_genes_under_MYF-03-69_treatments". The genes that were differentially expressed with statistical significance (Fold change > 1.5 and adjusted p value < 0.05) are listed in this dataset.</p> <p>To investigate whether TEAD inhibition by MYF-03-69 was selectively lethal to YAP/TEAD-dependent cancers, PRISM screening across a broad panel of cell lineages were performed and generated the spreadsheet "Supplementary_Dataset_3". 903 cancer cells were treated with TEAD inhibitor MYF-03-69 for 5 days. The viability values were measured at 8-point dose manner (3-fold dilution from 10 μM) and fitted a dose-response curve for each cell line. Area under the curve (AUC) was calculated as a measurement of compound effect on cell viability. CERES score of YAP1 or TEADs from CRISPR (Avana) Public 21Q1 dataset (DepMap) were listed in the spreadsheet and used to estimate gene-dependency. The CERES Score of most dependent TEAD isoform was used to represent TEAD dependency. With PRISM screen dataset of TEAD inhibitor MYF-03-69, we investigated whether TEAD inhibition recapulates genetically knockout outcome of YAP or TEADs and generated the spreadsheet "Supplementary_Dataset_4". Correlation analysis between compound PRISM sensitivity (log2.AUC of each cell line) and dependency of certain gene (CRISPR knockout score for each cell line, from DepMap Public 20Q4 Achilles_gene_effect.csv dataset) across the PRISM cell line panel. The Pearson correlation coefficients and associated p-values were computed. Positive correlations correspond to dependency correlating with increased sensitivity. The q-values (a corrected significance value accounting for false discovery rate) are computed from p-values using the Benjamini Hochberg algorithm. Associations with q-values above 0.1 are filtered out. This correlation analysis reveals that the dependency scores of TEAD1 and YAP1 according to genomic knockout dataset (DepMap portal) provided the highest correlation with the compound PRISM sensitivity profile. This is followed by TP53BP2, a gene that is also involved in Hippo pathway as activator of TAZ.</p>
Data from: Population genetic structure between Yap and Palau for the coral Acropora hyacinthus
Open the record for dataset details and reuse information.
Data from: Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling
Open the record for dataset details and reuse information.
Seasonal Variation of Deep Limb of Pacific Meridional Overturning Circulation at Yap-Mariana Junction
<p>This dataset contains deep velocity, temperature, and salinity data. It is supplementary of the paper “Seasonal Variation of Deep Limb of Pacific Meridional Overturning Circulation at Yap-Mariana Junction” published by the Journal of Geophysical Research-Oceans (https://doi.org/10.1029/2019JC016017). Please let me know if you need any more information.</p>
YAP and TAZ maintain PROX1 expression in the developing lymphatic and lymphovenous valves in response to VEGF-C signaling
<p>Lymphatic vasculature is an integral part of digestive, immune and circulatory systems. The homeobox transcription factor PROX1 is necessary for the development of lymphatic vessels, lymphatic valves (LVs) and lymphovenous valves (LVVs). We and others previously reported a feedback loop between PROX1 and Vascular Endothelial Growth Factor-C (VEGF-C) signaling. PROX1 promotes the expression of the VEGF-C receptor VEGFR3 in lymphatic endothelial cells (LECs). In turn, VEGF-C signaling maintains PROX1 expression in LECs. However, the mechanisms of PROX1/VEGF-C feedback loop remain poorly understood. Whether VEGF-C signaling is necessary for LV and LVV development is also unknown. Here, we report for the first time that VEGF-C signaling is necessary for valve morphogenesis. We have also discovered that the transcriptional co-activators YAP and TAZ are required to maintain PROX1 expression in LVs and LVVs in response to VEGF-C signaling. Deletion of <i>Yap</i> and <i>Taz</i> in the lymphatic vasculature of mouse embryos did not affect the formation of LVs or LVVs, but resulted in the degeneration of these structures. Our results have identified VEGF-C/YAP/TAZ as a critical molecular pathway in valve development.</p>
Food sources of benthic communities at the Caiwei Guyot and Yap Trench, northwestern Pacific Ocean: inferences from carbon and nitrogen isotopes
<p>To investigate nutritional resources for benthic communities at two sites in the northwestern Pacific Ocean (the Caiwei Guyot and the Yap Trench), stable isotopes of carbon and nitrogen (δ<sup>13</sup>C and δ<sup>15</sup>N) were measured in the tissues of megabenthic consumers (Porifera, Asteroidea, Crinoidea, Holothuroidea, Ophiuroidea, Gammaridea, and Actiniaria) as well as four potential food sources (suspended particles, sinking particles, zooplankton, and sedimentary organic matter, SOM). Fast-sinking particles are generally thought to be the primary food source for benthic consumers, but that paradigm does not seem to apply at these abyssal sites. Here, the δ<sup>13</sup>C and δ<sup>15</sup>N signatures of fast-sinking particles (as collected by sediment traps; δ<sup>13</sup>C = −24.1 to −22.6‰, δ<sup>15</sup>N = 1.4 to 5.4‰) were significantly lower than those of the megabenthos (δ<sup>13</sup>C = −20.1 to −16.1‰, δ<sup>15</sup>N = 10.2 to 17.9‰), indicating that these particles are not likely a direct food source for the animals. Buoyant particles (and slow-sinking particles), on the other hand, seem to be a significant direct food source for the megabenthos. Sedimentary organic matter and zooplankton are also important direct food sources. Trophic level analysis similarly indicates a diversity of food sources and suggests that for at least some animals, microbes (e.g., bacteria) may be a food source as well.</p>
FIGURE 6 in Decapoda: Anomura: Paguridae) from the Ryukyu and Yap Islands, and redescription of T. trichophthalmus (Forest)
FIGURE 6. Trichopagurus trichophthalmus (Forest, 1954). Male (SL 1.7 mm), NSMTCr 15233. A, chela of right cheliped, dorsal view (setae omitted); B, carpus of right cheliped (setae omitted); C, chela of left cheliped, dorsal view (setae omitted); D, carpus of left cheliped (setae omitted); E, right second pereopod, lateral view; F, same, dactylus, mesial view; G, left third pereopod, lateral view; H, left fourth pereopod, lateral view.
FIGURE 5 in Decapoda: Anomura: Paguridae) from the Ryukyu and Yap Islands, and redescription of T. trichophthalmus (Forest)
FIGURE 5. Trichopagurus trichophthalmus (Forest, 1954). Male (SL 1.7 mm), NSMTCr 15233. A, right cheliped, mesial view; B, same, lateral view; C, left cheliped, mesial view; D, same, lateral view.
FIGURE 4 in Decapoda: Anomura: Paguridae) from the Ryukyu and Yap Islands, and redescription of T. trichophthalmus (Forest)
FIGURE 4. Trichopagurus trichophthalmus (Forest, 1954). A–H, J, K, male (SL1.7 mm), NSMT Cr 15233; I, female (SL 1.6 mm), NSMTCr 15234. A, gill lamella; B, shield and cephalic appendages, dorsal view (setae omitted from left side); C, carapace, dorsal view (setae omitted from shield); D, left maxillule, ventral view; E, left third maxilliped, ventral view; F, same, basis and ischium, dorsal view; G, sixth thoracic sternite, ventral view; H, I, coxae of fifth pereopods and eighth thoracic sternite, ventral view; J, coxa of right fifth pereopod, lateral view; K, telson, dorsal view.
FIGURE 3. Trichopagurus macrochela n in Decapoda: Anomura: Paguridae) from the Ryukyu and Yap Islands, and redescription of T. trichophthalmus (Forest)
FIGURE 3. Trichopagurus macrochela n. sp. Holotype male (SL 1.8 mm), CBMZC 7853. A, chela and carpus of right cheliped, dorsal view (setae omitted); B, right cheliped, mesial view; C, same, lateral view; D, chela and carpus of left cheliped, dorsal view (setae omitted); E, left cheliped, lateral view; F, same, mesial view (setae omitted).
FIGURE 2. Trichopagurus macrochela n in Decapoda: Anomura: Paguridae) from the Ryukyu and Yap Islands, and redescription of T. trichophthalmus (Forest)
FIGURE 2. Trichopagurus macrochela n. sp. Holotype male (SL 1.8 mm), CBMZC 7853. A, left maxillule, ventral view; B, left maxilla, ventral view; C, left first maxilliped, ventral view; D, left second maxilliped, ventral view; E, left third maxilliped, ventral view; F, same, basis and ischium, dorsal view; G, right second pereopod, lateral view; H, left third pereopod, lateral view; I, dactylus of right second pereopod, mesial view; J, dactylus of left third pereopod, mesial view.
FIGURE 1. Trichopagurus macrochela n in Decapoda: Anomura: Paguridae) from the Ryukyu and Yap Islands, and redescription of T. trichophthalmus (Forest)
FIGURE 1. Trichopagurus macrochela n. sp. A, B, E, F, H, J, K, holotype male (SL 1.8 mm), CBMZC 7853; C, paratype male (SL 2.0 mm), CBMZC 7854; D, G, I, paratype female (SL 2.5 mm), CBMZC 7854. A, gill lamella; B, shield and cephalic appendages, dorsal view; C, carapace, dorsal view; D, left fourth pereopod, lateral view; E, right fifth pereopod, lateral view; F, sixth thoracic sternite, ventral view; G, coxae of third pereopods and sixth thoracic sternite, ventral view; H, I, coxae of fifth pereopods and eighth thoracic sternite, ventral view; J, telson, dorsal view; K, left posterior lobe of telson, lateral view.
FIGURE 5 in Cuapetes yapiensis sp. nov. (Crustacea: Decapoda: Pontoniinae), a new mangrove shrimp from Yap, Caroline Islands
FIGURE 5. Cuapetes yapiensis sp. nov., ovigerous female paratype, Qamun, Yap, Caroline Islands, QM W29189. A, left inferior orbital region, dorsal. B, antennule, distolateral angle of proximal segment. C, scaphocerite, distal margin. D, mandible, molar process, dorsal. E, same, ventral. F, same, incisor process. G, maxillula, palp. H, second maxilliped, distomedial propod. I, fourth and fifth thoracic sternites.
FIGURE 2 in Cuapetes yapiensis sp. nov. (Crustacea: Decapoda: Pontoniinae), a new mangrove shrimp from Yap, Caroline Islands
FIGURE 2. Cuapetes yapiensis sp. nov., ovigerous female paratype, Qamun, Yap, Caroline Islands, QM W29189. A, carapace and rostrum. B, anterior carapace, eyes and antennae, dorsal. C, rostrum and orbital region. D, left inferior orbital angle and orbit, dorsal. E, eye, dorsal. F, antennule. G, antenna. H, fifth abdominal pleuron. I, telson. J, same posterior spines, dorsal spines inset. K, uropod.
FIGURE 1 in Cuapetes yapiensis sp. nov. (Crustacea: Decapoda: Pontoniinae), a new mangrove shrimp from Yap, Caroline Islands
FIGURE 1. Cuapetes yapiensis sp. nov., male holotype, Qamun, Yap, Caroline Islands, QM W29188. Scale bar in millimeters.
FIGURE 4 in Cuapetes yapiensis sp. nov. (Crustacea: Decapoda: Pontoniinae), a new mangrove shrimp from Yap, Caroline Islands
FIGURE 4. Cuapetes yapiensis sp. nov., ovigerous female paratype, Qamun, Yap, Caroline Islands, QM W29189. A, first pereiopod. B, same, chela. C, same, tips of fingers. D, second pereiopod. E, same, chela. F, same, fingers. G, fourth pereiopod. H, same, propod and dactyl. I, same, distal propod and dactyl.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
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