Find research datasets worth reusing

opennotspecifiedApr 2023View details →

Fig. 6 in Insight into tetrahydrofuran lignans from Isatis indigotica fortune with neuroprotective and acetylcholinesterase inhibitor activity

Fig. 6. The neuroprotective effects of compounds 1a/1b-7 against H2O2-induced injury in SH-SY5Y cells. After H2O2 (200 μM) treatment, cell viabilities were determined by MTT assay in the presence or absence of the tested compounds at different concentrations (12.5, 25, 50 μM).

opennotspecifiedJan 2022View details →

Fig. 7 in Thirteen cyathane diterpenoids with acetylcholinesterase inhibitory effects from the fungus Cyathus africanus

Fig. 7. The binding modes of 9 (A), 10 (B) and 11 (C) with human AChE (PDB ID: 4M0F). Hydrogen bond interactions were depicted with red dotted lines in Å. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

opennotspecifiedOct 2021View details →

Fig. 6 in Euphorfinoids E-L: Diterpenoids from the roots of Euphorbia fischeriana with acetylcholinesterase inhibitory activity

Fig. 6. Post-docking interactions between active residues of AChE with compound 1. (A) the protein was depicted in surface view and ligands as stick in the binding pocket. (B) schematic drawing of types of interactions of the ligands generated using ligplot.

opennotspecifiedFeb 2021View details →

Fig. 2 in (þ/¡)-Dievodialetins A¡G: Seven pairs of enantiomeric coumarin dimers with anti-acetylcholinesterase activity from the roots of Evodia lepta Merr.

Fig. 2. (A) Key 1H–1H COSY (red bold lines) and HMBC (blue arrows) correlations of 1. (B) X-ray ORTEP schematic of 1. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)

opennotspecifiedFeb 2021View details →

Fig. 5. Compounds 1–9 in (þ/¡)-Dievodialetins A¡G: Seven pairs of enantiomeric coumarin dimers with anti-acetylcholinesterase activity from the roots of Evodia lepta Merr.

Fig. 5. Compounds 1–9 ameliorate oxidative stress and neuroinflammation in scopolamine-treated SH-SY5Y cells.

Fig. 6. Linear correlation plots between the experimental and calculated 13C in Structurally diverse alkaloids with nine frameworks from Zephyranthes candida and their acetylcholinesterase inhibitory and anti-inflammatory activities

Fig. 6. Linear correlation plots between the experimental and calculated 13C NMR data for two isomers of 2.

Fig. 4 in Structurally diverse alkaloids with nine frameworks from Zephyranthes candida and their acetylcholinesterase inhibitory and anti-inflammatory activities

Fig. 4. Experimental and calculated ECD spectra of zephyranines A (1) and B (2) and their enantiomers.

Fig. 3. Linear correlation plots between the experimental and calculated 13C in Structurally diverse alkaloids with nine frameworks from Zephyranthes candida and their acetylcholinesterase inhibitory and anti-inflammatory activities

Fig. 3. Linear correlation plots between the experimental and calculated 13C NMR data for four isomers of 1.

Fig. 10 in Structurally diverse alkaloids with nine frameworks from Zephyranthes candida and their acetylcholinesterase inhibitory and anti-inflammatory activities

Fig. 10. The binding modes of 1 (A), 7 (B), 8 (C), and galanthamine (D) with AChE (PDB ID: 4M0E). The hydrogen bonds are indicated by red dashed lines. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

Fig. 8 in Structurally diverse alkaloids with nine frameworks from Zephyranthes candida and their acetylcholinesterase inhibitory and anti-inflammatory activities

Fig. 8. Experimental ECD spectra of zephyranines G–I (7–9), 6-O-ethylnerinine (10) and the calculated ECD spectra of zephyranine G (7), the aglycone of zephyranine H (8), zephyranine I (9), 6-O-ethylnerinine (10), and their enantiomers.

Fig. 7 in Structurally diverse alkaloids with nine frameworks from Zephyranthes candida and their acetylcholinesterase inhibitory and anti-inflammatory activities

Fig. 7. Experimental and calculated ECD spectra of zephyranines C F (3–6), isolated as mixtures of respective 6-epimers (d. r. 75: 25), and their enantiomers.

opennotspecifiedJul 2020View details →

Fig. 3 in Gigantelline, gigantellinine and gigancrinine, cherylline- and crinine-type alkaloids isolated from Crinum jagus with anti-acetylcholinesterase activity

Fig. 3. Experimental ECD spectra of gigantelline (1) (black solid line), gigantellinine (2) (blue dotted line) and cherylline (5) (green dashed line) measured in methanol (ca. 3 mM, 0.1 cm cell). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

restrictedIPD-UNDECIDEDFeb 2026View details →

Evaluate the Efficacy and Safety of ABT-126 in Subjects With Mild to Moderate Alzheimer's Disease on Stable Doses of Acetylcholinesterase Inhibitors

ClinicalTrials.gov study NCT01549834. IPD Sharing: Not stated. Countries: 7. Publications: 1.

restrictedIPD-UNDECIDEDFeb 2026View details →

Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ABT-957 in Subjects With Mild-to-Moderate Alzheimer's Disease on Stable Doses of Acetylcholinesterase Inhibitors

ClinicalTrials.gov study NCT02220738. IPD Sharing: Not stated. Countries: 1. Publications: 1.

closedIPD-NOFeb 2026View details →

Effect of Acetylcholinesterase Inhibitors on Bone Metabolism

ClinicalTrials.gov study NCT06041789. IPD Sharing: NO. Countries: 1. Publications: 0.