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381 results for “acute respiratory distress syndrome”
DATA SET: Peripheral microcirculatory alterations are associated with the severity of acute respiratory distress syndrome in COVID-19 patients admitted to intermediate respiratory and intensive care units
<p>This repository contains the data sets of the article:</p> <p>Mesquida, J., Caballer, A., Cortese, L. <em>et al.</em> Peripheral microcirculatory alterations are associated with the severity of acute respiratory distress syndrome in COVID-19 patients admitted to intermediate respiratory and intensive care units. <em>Crit Care</em> <strong>25, </strong>381 (2021). https://doi.org/10.1186/s13054-021-03803-2</p>
Acute Respiratory Distress Syndrome-Database of Genes (ARDS-DB)
<p>To better understand the gene level associations that are most relevant to Acute Respiratory Distress Syndrome (ARDS), a comprehensive resource is needed. There’s currently no freely available database dedicated to ARDS that provides comprehensive gene lists from experimentally verifiable studies, gene function, gene location, and additional metadata for tracking related link out resources. The need for such a database is only accentuated by the steep rise in ARDS cases due to the 2020 Coronavirus pandemic, in which infected patients admitted to the ICU develop ARDS at a rate of 67% to 85%, calling for an increase into ARDS research. </p> <p>Our goal was to develop such a resource for use by the scientific community to enhance our studies of ARDS and associated genes. Our first step was to perform data mining and curation of scientific literature through a robust review process. Subsequent steps enabled us to refine our data by capturing specific metadata and incorporating these into our database. The version 1 of the database will provide users with access to the database flat file with current genes, gene location, chromosomal information, and more in a freely accessible and downloadable format. Future project goals are to develop a standalone web portal that will integrate the gene level information with network analysis, and other visualizations for users. </p> <p> </p>
Dataset for the paper "Prolonged prothrombin time as an early prognostic indicator of severe acute respiratory distress syndrome in patients with COVID-19 related pneumonia"
<p>The dataset contains the data on ICU-transferred (N=100) and Stable (N=131) patients with COVID-19 (N=156) and Non-COVID-19 viral pneumonia (N=75). Among COVID-19 patients of this study, 82 patients developed Refractory Respiratory Failure (RRF) or Severe Acute Respiratory Distress Syndrome (SARDS) and were transferred to Intensive Care Unit (ICU), 74 patients had a Stable course of disease and were not transferred to ICU. Collected data are presented as a table with columns:<br> - Gender;<br> - Age (years);<br> - SARS-CoV-2 RT-PCR testing results;<br> - Time between the disease onset and admission to the hospital (days);<br> - Time between admission to the hospital and transfer to ICU (days);<br> - Artificial lung ventilation in ICU needed;<br> - C-reactive protein (CRP) upon admission (mg/L);<br> - International Normalized Ratio (INR) upon admission;<br> - Prothrombin Time (PT) upon admission (sec.);<br> - Fibrinogen upon admission (mg/L);<br> - Chest Computed Tomography (CT) upon admission: lung tissue affected (%);<br> - Platelet count upon admission (10^9/L);<br> - Chest CT, 1 week after admission: lung tissue affected (%);<br> - CRP, 1 week after admission (mg/L);<br> - Platelet count, 1 week after admission (10^9/L).</p>
Unveiling Pathophysiological Insights: Serum Metabolic Dysregulation in Acute Respiratory Distress Syndrome Patients with Acute Kidney Injury
<p>The uploaded data is an Excel sheet obtained after performing the binning of 1H CPMG NMR spectra acquired using 800 MHz NMR on the serum samples of ARDS patients and ARDS with AKI patients. </p>
The impact of severity of acute respiratory distress syndrome following cardiac arrest on neurologic outcomes
<p>Overall survival rates at 28 days in patients with and without ARDS. ARDS = acute respiratory distress syndrome</p>
Linking Endotypes and Outcomes in Pediatric Acute Respiratory Distress Syndrome
ClinicalTrials.gov study NCT04113434. IPD Sharing: YES. Countries: 1. Publications: 1.
Pharmacokinetic dataset of a randomized controlled trial investigating the efficacy and safety of intravenous imatinib mesylate (Impentri®) in subjects with acute respiratory distress syndrome induced by COVID-19
<p>Abstract</p> <p>Background</p> <p>The coronavirus disease 2019 (COVID-19) pandemic has led to a disruptive increase in the number of intensive care unit (ICU) admissions with acute respiratory distress syndrome (ARDS). ARDS is a severe, life-threatening medical condition characterized by widespread inflammation and vascular leak in the lungs. Although there is no proven therapy to reduce pulmonary vascular leak in ARDS, recent studies demonstrated that the tyrosine kinase inhibitor imatinib reinforces the endothelial barrier and prevents vascular leak in inflammatory conditions, while leaving the immune response intact.</p> <p>Methods</p> <p>This is a randomized, double-blind, parallel-group, placebo-controlled, multicenter clinical trial of intravenous (IV) imatinib mesylate in 90 mechanically ventilated subjects with COVID-19-induced ARDS. Subjects are 18 years or older, admitted to the ICU for mechanical ventilation, meeting the Berlin criteria for moderate-severe ARDS with a positive polymerase chain reaction test for SARS-CoV2. Participants will be randomized in a 1:1 ratio to either imatinib (as mesylate) 200 mg bis in die (b.i.d.) or placebo IV infusion for 7 days, or until ICU discharge or death. The primary study outcome is the change in Extravascular Lung Water Index (EVLWi) between day 1 and day 4. Secondary outcome parameters include changes in oxygenation and ventilation parameters, duration of invasive mechanical ventilation, number of ventilator-free days during the 28-day study period, length of ICU stay, and mortality during 28 days after randomization. Additional secondary parameters include safety, tolerability, and pharmacokinetics.</p> <p>Discussion</p> <p>The current study aims to investigate the efficacy and safety of IV imatinib in mechanically ventilated subjects with COVID-19-related ARDS. We hypothesize that imatinib decreases pulmonary edema, as measured by extravascular lung water using a PiCCO catheter. The reduction in pulmonary edema may reverse hypoxemic respiratory failure and hasten recovery. As pulmonary edema is an important contributor to ARDS, we further hypothesize that imatinib reduces disease severity, reflected by a reduction in 28-day mortality, duration of mechanical ventilation, and ICU length of stay.</p>
Safety Study of Inhaled Carbon Monoxide to Treat Pneumonia and Sepsis-Induced Acute Respiratory Distress Syndrome (ARDS)
ClinicalTrials.gov study NCT04870125. IPD Sharing: YES. Countries: 1. Publications: 12.
Sigh Ventilation to Increase Ventilator-Free Days in Victims of Trauma at Risk for Acute Respiratory Distress Syndrome
ClinicalTrials.gov study NCT02582957. IPD Sharing: NO. Countries: 1. Publications: 1.
Electrical Impedance Tomography for Optimization of Positive End-Expiratory Pressure: Acute Respiratory Distress Syndrome
ClinicalTrials.gov study NCT03793842. IPD Sharing: NO. Countries: 1. Publications: 1.
Defibrotide Therapy for SARS-CoV2 (COVID-19) Acute Respiratory Distress Syndrome (ARDS)
ClinicalTrials.gov study NCT04530604. IPD Sharing: NO. Countries: 1. Publications: 1.
Effects of TNX-832 (Sunol cH36) in Subjects With Acute Lung Injury/Acute Respiratory Distress Syndrome
ClinicalTrials.gov study NCT01438853. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Intensive Nutrition in Acute Respiratory Distress Syndrome (ARDS): A Clinical Trial (INTACT)
ClinicalTrials.gov study NCT01921101. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Human Mesenchymal Stromal Cells For Acute Respiratory Distress Syndrome (START)
ClinicalTrials.gov study NCT02097641. IPD Sharing: NO. Countries: 1. Publications: 4.
Exploration of Diagnosis and Treatment Strategies and Prognostic Prediction Models for Acute Respiratory Distress Syndrome Based on Radiographic Evaluations Assessed by Artificial Intelligence
ClinicalTrials.gov study NCT07328997. IPD Sharing: YES. Countries: 1. Publications: 30.
Mesenchymal Stromal Cells For Acute Respiratory Distress Syndrome
ClinicalTrials.gov study NCT03818854. IPD Sharing: NO. Countries: 1. Publications: 1.
A Study to Assess the Efficacy and Safety of Gimsilumab in Subjects With Lung Injury or Acute Respiratory Distress Syndrome Secondary to COVID-19 (BREATHE)
ClinicalTrials.gov study NCT04351243. IPD Sharing: NO. Countries: 1. Publications: 1.
Pediatric Acute Respiratory Distress Syndrome Asia Study
ClinicalTrials.gov study NCT04068038. IPD Sharing: UNDECIDED. Countries: 10. Publications: 1.
Prolonged Prone Positioning for COVID-19-induced Acute Respiratory Distress Syndrome (ARDS)
ClinicalTrials.gov study NCT04581811. IPD Sharing: NO. Countries: 1. Publications: 1.
Efficacy and Safety of FP-1201-lyo (Interferon Beta-1a) in Patients Having Acute Respiratory Distress Syndrome (ARDS)
ClinicalTrials.gov study NCT02622724. IPD Sharing: NO. Countries: 8. Publications: 2.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.