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5 results for “adhesion GPCR”
The adhesion GPCR GPR116/ADGRF5 has a dual function in pancreatic islets regulating somatostatin release and islet development
<p><span>Glucose homeostasis is maintained by hormones secreted from different cell types of the pancreatic islets and controlled by manifold input including signals mediated through G protein-coupled receptors (GPCRs). RNA-seq analyses revealed expression of numerous GPCRs in mouse and human pancreatic islets, among them <em>Gpr116</em>/<em>Adgrf5</em>. GPR116 is an adhesion GPCR mainly found in lung and required for surfactant secretion. Here, we demonstrate that GPR116 is involved in the somatostatin release from pancreatic delta cells using a whole-body as well as a cell-specific knock-out mouse model. Interestingly, the whole-body GPR116 deficiency causes further changes such as decreased beta-cell mass, lower number of small islets, and reduced pancreatic insulin content. Glucose homeostasis in global GPR116-deficient mice is maintained by counter-acting mechanisms modulating insulin degradation. Our data highlight an important function of GPR116 in controlling glucose homeostasis. </span></p>
Data for Alternative Splicing of Adhesion-GPCR Latrophilin-3 Controls Synapse Formation
GEO Series GSE240791. Mus musculus. 13 samples. Type: Expression profiling by high throughput sequencing; Other.
Adhesion GPCR ADGRE2 maintains proteostasis to promote progression in acute myeloid leukemia
GEO Series GSE261574. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Adhesion GPCR CD97 promotes spleen dendritic cell retention and function through sensing of CD55-expressing red blood cells
GEO Series GSE188835. Mus musculus. 21 samples. Type: Expression profiling by high throughput sequencing.
Adhesion GPCR, latrophilin-2, specifies cardiac lineage commitment through CDK5, Src, and P38MAPK
GEO Series GSE92923. Homo sapiens; Mus musculus; Rattus norvegicus. 6 samples. Type: Protein profiling by protein array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.