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214 results for “adipogenesis”
Latent Transforming Growth Factor β Binding Protein 3 Controls Adipogenesis
<p>Transforming growth factor-beta (TGFβ) is released from cells as part of a trimeric latent complex consisting of TGFβ, the TGFβ propeptides, and either a latent TGFβ binding protein (LTBP) or glycoprotein-A repetitions predominant (GARP) protein. LTBP1 and 3 modulate latent TGFβ function with respect to secretion, matrix localization, and activation and, therefore, are vital for the proper function of the cytokine in a number of tissues. TGFβ modulates stem cell differentiation into adipocytes (adipogenesis), but the potential role of LTBPs in this process has not been studied. We observed that 72 h post adipogenesis initiation <em>Ltbp1</em>, <em>2</em>, and <em>4 </em>expression levels decrease by 74-84%, whereas <em>Ltbp3 </em>expression levels remain constant during adipogenesis. We found that LTBP3 silencing in C3H/10T1/2 cells reduced adipogenesis, as measured by the percentage of cells with lipid vesicles and the expression of the transcription factor peroxisome proliferator-activated receptor gamma (PPARγ). Lentiviral mediated expression of an <em>Ltbp3 </em>mRNA resistant to siRNA targeting rescued the phenotype, validating siRNA specificity. Knockdown (KD) of Ltbp3 expression in 3T3-L1, M2, and primary bone marrow stromal cells (BMSC) indicated a similar requirement for <em>Ltbp3</em>. Epididymal and inguinal white adipose tissue fat pad weights of <em>Ltbp3</em><sup>-/-</sup> mice were reduced by 62% and 57%, respectively, compared to wild-type mice. Inhibition of adipogenic differentiation upon LTBP3 loss is mediated by TGFβ, as TGFβ neutralizing antibody and TGFβ receptor I kinase blockade rescue the LTBP3 KD phenotype. These results indicate that LTBP3 has a TGFβ-dependent function in adipogenesis both in vitro and possibly in vivo. </p>
FGF-2-dependent signaling activated in aged human skeletal muscle promotes intramuscular adipogenesis
<p><span><span><span><span><span><span><span><span><span><span><span>Aged skeletal muscle is markedly affected by fatty muscle infiltration and strategies to reduce the occurrence of intramuscular adipocytes are urgently needed. Here, we show that fibroblast growth factor-2 (FGF-2) not only stimulates muscle growth, but also promotes intramuscular adipogenesis. Using multiple screening assays upstream and downstream of microRNA (miR)-29a signaling, we located the secreted protein and adipogenic inhibitor SPARC to an FGF-2 signaling pathway that is conserved between skeletal muscle cells from mice and humans and that is activated in skeletal muscle of aged mice and humans. FGF-2 induces the miR-29a/SPARC axis through transcriptional activation of FRA-1, which binds and activates an evolutionary conserved AP-1 site element proximal in the miR-29a promoter. Genetic deletions in muscle cells and AAV-mediated overexpression of FGF-2 or SPARC in mouse skeletal muscle revealed that this axis regulates differentiation of fibro/adipogenic progenitors <i>in vitro</i> and intramuscular adipose tissue (IMAT) formation <i>in vivo</i>. Skeletal muscle from human donors aged > 75 years versus < 55 years showed activation of FGF-2-dependent signaling and increased IMAT. Thus, our data highlights a disparate role of FGF-2 in adult skeletal muscle and reveals a novel pathway to combat fat accumulation in aged human skeletal muscle.</span></span></span></span></span></span></span></span></span></span></span></p>
Latent Transforming Growth Factor β Binding Protein 3 Controls Adipogenesis
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FGF-2-dependent signaling activated in aged human skeletal muscle promotes intramuscular adipogenesis
Open the record for dataset details and reuse information.
Quantification of Human Adipogenesis
ClinicalTrials.gov study NCT01257997. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis
GEO Series GSE164892. Mus musculus. 4 samples. Type: Methylation profiling by high throughput sequencing.
Bmi1 suppresses adipogenesis in the hematopoietic stem cell niche: RNA-Seq
GEO Series GSE121288. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Nervonic acid improves the fat transplantation by promoting adipogenesis and angiogenesis
GEO Series GSE269065. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
The fat cell epigenetic signature in post-obese women is characterized by global hypomethylation and differential DNA methylation of adipogenesis genes
GEO Series GSE58622. Homo sapiens. 30 samples. Type: Methylation profiling by array.
MicroRNA expression profiling of human adipose stromal cell (hASC) adipogenesis
GEO Series GSE20699. Homo sapiens. 19 samples. Type: Non-coding RNA profiling by array.
Prep1 prevents premature adipogenesis of mesenchymal progenitors [RNA-seq]
GEO Series GSE100056. Mus. 8 samples. Type: Expression profiling by high throughput sequencing.
GR accelerates, but is largely dispensable for, adipogenesis
GEO Series GSE76619. Mus musculus. 30 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Quizalofop-p-ethyl induces adipogenesis in 3T3-L1 cells
GEO Series GSE121419. Mus musculus. 30 samples. Type: Expression profiling by high throughput sequencing.
The effects of TGFBR3 on adipogenesis of FAPs
GEO Series GSE283671. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
An adipose lncRAP2 - Igf2bp2 complex enhances adipogenesis and energy expenditure by stabilizing target mRNAs [RIP-seq]
GEO Series GSE192705. Mus musculus. 9 samples. Type: Other.
Anti-PDGFcc antibody treatment increases adipogenesis pathways in inguinal white adipose tissue
GEO Series GSE169226. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Extensive Chromatin Remodeling and Establishment of Transcription Factor 'Hotspots' during Early Adipogenesis
GEO Series GSE27826. Mus musculus. 20 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
3D chromatin organization changes modulate adipogenesis and osteogenesis [RNA-seq]
GEO Series GSE151322. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
A mixture of endocrine disrupting chemicals associated with lower birth weight in children induces adipogenesis and DNA methylation changes in human mesenchymal stem cells
GEO Series GSE196046. Homo sapiens. 24 samples. Type: Methylation profiling by genome tiling array.
Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming [single-cell RNA-seq]
GEO Series GSE227439. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.