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696 results for “adrenal”
Full summary statistics of mixQTL for GTEx v8 Adrenal_Gland
The mixQTL method is described in paper doi.org/10.1101/2020.04.22.050666. Please cite the original paper if using the data.
Supplemental file for the manuscript "Utility of salivary cortisol and cortisone in the diagnostics of adrenal insufficiency"
<p>Supplemental file for the manuscript "Utility of salivary cortisol and cortisone in the diagnostics of adrenal insufficiency"</p>
Adult adrenal gland scRNA-seq
<p>Adult adrenal gland scRNA-seq dataset. Gene expression matrices (in dgCMatrix format) are provided as RDS files. Cell annotations (cell types, cortex zonations, and genotypes) are provided in CSV format.</p>
Quantitative PCR from human genomic DNA: the determination of gene copy numbers for congenital adrenal hyperplasia and RCCX copy number variation
<p>The dataset is related a study in which we aimed to simultaneously assess the performance of 7 quantitative polymerase chain reaction (qPCR) assays for the gene copy number (GCN) determination of the genetic elements of RCCX copy number variation (CNV). A single laboratory method validations of duplex qPCR assays with hydrolysis probes on <em>CYP21A1P</em> and <em>CYP21A2</em> genes, which are responsible for congenital adrenal hyperplasia, were performed using 46 human genomic DNA samples. We also performed the verifications on 5 qPCR assays for the genetic elements of RCCX CNV such as <em>C4A</em> gene, <em>C4B</em>, gene, RCCX CNV breakpoint, HERV-K(C4) CNV deletion and insertion alleles. The dataset contains the data of genomic DNA samples, the raw quantification cycle values of all qPCR experiments, the peak heights and dosage quotient of multiplex ligation-dependent probe amplification (MLPA) experiments, and the detailed GCN results based on qPCR and MLPA. All other analyses are available in our publication under the same title.</p>
Data of Fig 4 "Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids"
<p>Dataset containes all data of Figure 4 of the publication "Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids" (DOI: 10.3389/fphar.2024.1394846)</p>
Figure 5 "Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids"
<p>Dataset containes all data of Figure 5 of the publication "Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids" (DOI: 10.3389/fphar.2024.1394846)</p>
Dataset of Fig 3 "Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids"
<p>Dataset containes all data of Figure 3 of the publication "Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids" (DOI: 10.3389/fphar.2024.1394846)</p>
Data for: Corticosteroid-binding globulin (SERPINA6) establishes postpubertal sex differences in rat adrenal development
<p>Encoded by SerpinA6, plasma corticosteroid-binding globulin (CBG) transports glucocorticoids and regulates their access to cells. We determined how CBG influences plasma corticosterone and adrenal development in rats during the pubertal to adult transition using CRISPR/cas9 to disrupt SerpinA6 gene expression. In the absence of CBG, total plasma corticosterone levels were ∼80% lower in adult rats of both sexes, with a greater absolute reduction in females than in males. Notably, free corticosterone and adrenocorticotropic hormone were comparable between all groups. Between 30 and 90 days of age, wild-type female rats showed increases in adrenal weight and the size of the corticosterone-producing region, the zona fasciculata (zf), in tandem with increases in plasma CBG and corticosterone concentrations, whereas no such changes were observed in males. This sex difference was lost in rats without CBG, such that adrenal growth and zf expansion were similar between sexes. The sex-specific effects of CBG on adrenal morphology were accompanied by remarkable changes in gene expression: ∼40% of the adrenal transcriptome was altered in females lacking CBG, whereas almost no effect was seen in males. Over half of the adrenal genes that normally exhibit sexually dimorphic expression after puberty were similarly expressed in males and females without CBG, including those responsible for cholesterol biosynthesis and mobilization, steroidogenesis, and growth. Rat adrenal SerpinA6 transcript levels were very low or undetectable. Thus, sex differences in adrenal growth, morphology and gene expression profiles that emerge during puberty in rats are dependent on concomitant increases in plasma CBG produced by the liver.</p>
Supplemental material for the paper "Genotype-phenotype correlation, clinical presentation, and feminizing surgery in children with congenital adrenal hyperplasia - a nationwide study"
<p>This dataset provides documentation for the translation between historical nomenclature for variants in the CYP21A2 gene to the Human genome variation society nomenclature. </p> <p>Furthermore, it provides data on all Danish CYP21A2 variants included in the study and the translation into genotype groups: Null, A, B, C, and D. </p>
Supplement: In situ spatial reconstruction of distinct normal and pathological cell populations within the human adrenal gland
<p>Supplemental legends, figure, and table for In situ spatial reconstruction of distinct normal and pathological cell populations within the human adrenal gland.</p>
Study of SPR001 in Adults With Classic Congenital Adrenal Hyperplasia
ClinicalTrials.gov study NCT03257462. IPD Sharing: NO. Countries: 1. Publications: 1.
Nasacort AQ Hypothalamic-Pituitary-Adrenal (HPA) Axis Study in Children With Allergic Rhinitis
ClinicalTrials.gov study NCT01154153. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Three Drug Combination Therapy Versus Conventional Treatment of Children With Congenital Adrenal Hyperplasia
ClinicalTrials.gov study NCT00001521. IPD Sharing: NO. Countries: 1. Publications: 1.
Comparison of Two Forms of Hydrocortisone in Patients With Congenital Adrenal Hyperplasia
ClinicalTrials.gov study NCT00519818. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Clinical Outcome of Autonomous Cortisol Secretion in Adrenal Incidentalomas
ClinicalTrials.gov study NCT04917757. IPD Sharing: UNDECIDED. Countries: 2. Publications: 1.
Glucocorticoid Receptor Blockade With Mifepristone in Patients With Mild Adrenal Hypercortisolism
ClinicalTrials.gov study NCT01990560. IPD Sharing: Not stated. Countries: 1. Publications: 12.
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of NBI-74788 (Crinecerfont) in Pediatric Participants With Congenital Adrenal Hyperplasia
ClinicalTrials.gov study NCT04045145. IPD Sharing: NO. Countries: 1. Publications: 1.
Androgen Reduction in Congenital Adrenal Hyperplasia, Phase 1
ClinicalTrials.gov study NCT02574910. IPD Sharing: YES. Countries: 1. Publications: 1.
Global Safety and Efficacy Registration Study of Crinecerfont in Pediatric Participants With Classic Congenital Adrenal Hyperplasia (CAHtalyst Pediatric Study)
ClinicalTrials.gov study NCT04806451. IPD Sharing: NO. Countries: 10. Publications: 1.
Global Safety and Efficacy Registration Study of Crinecerfont for Congenital Adrenal Hyperplasia
ClinicalTrials.gov study NCT04490915. IPD Sharing: NO. Countries: 18. Publications: 1.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.