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75 results for “adult neurogenesis”
Pre-existing natural variations of adult neurogenesis and anxiety predict hierarchical social status of inbred male mice.
<p>CVS files and image files of all data presented in the correcponding figures. </p>
Pregnancy-Responsive Pools of Adult Neural Stem Cells For Transient Neurogenesis in Mothers
<p>These are the RDS objects of the resulting files from our analyses, converted to Spatial Experiment object. These files can be loaded into spatialLIBD directly to allow interactive exploration of the data locally.</p> <p>In the new version of the dataset, we included the high resolution .tiff images of all of the samples. Furthermore, we included the low resolution (lowres) output from the spaceranger for the researchers who want to use these files. Higher resolution images (hires) were previously shared in the GEO submission alongside the raw sequencing data.</p>
Inactive but awake behaviour as indicating a depression-like state in mice: Aetiological factors and association with adult hippocampal neurogenesis
Open the record for dataset details and reuse information.
Adult neurogenesis improves spatial information encoding in the mouse hippocampus - EE dataset
<p><strong>In vivo two-photon imaging dataset for Frechou et al. "Adult neurogenesis improves spatial information encoding in the mouse hippocampus"</strong></p> <p>This dataset includes data from mice that were housed in an enriched environment (EE). </p> <p>For each recording we included raw imaging data consisting of:</p> <ul> <li>Individual frames (.tif files) from 3 consecutive 3 min Ca2+ imaging movies (which were concatenated for analysis)</li> <li>Microscope settings metadata (Experiment.xml)</li> <li>Mouse location data (Episode001.h5 in SyncData folder) containing rotary encoder and RFID data</li> </ul> <p>Some analyzed data is also included:</p> <ul> <li>Suite2p analysis data (<strong>Suite2p</strong> folder)</li> <li><strong>fluorescence.npy </strong>contains raw fluorescence data (the F output of Suite2p data extraction). Rows are individual cells and columns are frames (i.e. timepoints) acquired at 15.253 Hz.</li> <li><strong>positions.npy </strong>contains the position of the mouse on the treadmill belt indexed from 0 to 100.</li> </ul> <p>Both NumPy(.npy) files are the output of the Preprocessing.py code, part of the analysis pipeline used for data analysis in the original publication, which can be found at <a href="https://github.com/GoncalvesLab/Frechou-et-al-Neurogenesis">https://github.com/GoncalvesLab/Frechou-et-al-Neurogenesis</a></p> <p>All imaged mice were female. Refer to the original publication for additional information. </p>
Adult neurogenesis improves spatial information encoding in the mouse hippocampus - Irr+EE
<p><strong>In vivo two-photon imaging dataset for Frechou et al. "Adult neurogenesis improves spatial information encoding in the mouse hippocampus"</strong></p> <p>This dataset includes data from mice that were irradiated to ablate adult neurogenesis and housed in an enriched environment (Irr+EE). </p> <p>For each recording we included raw imaging data consisting of:</p> <ul> <li>Individual frames (.tif files) from 3 consecutive 3 min Ca2+ imaging movies (which were concatenated for analysis)</li> <li>Microscope settings metadata (Experiment.xml)</li> <li>Mouse location data (Episode001.h5 in SyncData folder) containing rotary encoder and RFID data</li> </ul> <p>Some analyzed data is also included:</p> <ul> <li>Suite2p analysis data (<strong>Suite2p</strong> folder)</li> <li><strong>fluorescence.npy </strong>contains raw fluorescence data (the F output of Suite2p data extraction). Rows are individual cells and columns are frames (i.e. timepoints) acquired at 15.253 Hz.</li> <li><strong>positions.npy </strong>contains the position of the mouse on the treadmill belt indexed from 0 to 100.</li> </ul> <p>Both NumPy(.npy) files are the output of the Preprocessing.py code, part of the analysis pipeline used for data analysis in the original publication, which can be found at <a href="https://github.com/GoncalvesLab/Frechou-et-al-Neurogenesis">https://github.com/GoncalvesLab/Frechou-et-al-Neurogenesis</a></p> <p>All imaged mice were female. Refer to the original publication for additional information. </p>
Adult neurogenesis improves spatial information encoding in the mouse hippocampus - Irr+RC
<p><strong>In vivo two-photon imaging dataset for Frechou et al. "Adult neurogenesis improves spatial information encoding in the mouse hippocampus"</strong></p> <p>This dataset includes data from mice that werethat were irradiated to ablate adult neurogenesis and housed in a regular cage (Irr+RC). </p> <p>For each recording we included raw imaging data consisting of:</p> <ul> <li>Individual frames (.tif files) from 3 consecutive 3 min Ca2+ imaging movies (which were concatenated for analysis)</li> <li>Microscope settings metadata (Experiment.xml)</li> <li>Mouse location data (Episode001.h5 in SyncData folder) containing rotary encoder and RFID data</li> </ul> <p>Some analyzed data is also included:</p> <ul> <li>Suite2p analysis data (<strong>Suite2p</strong> folder)</li> <li><strong>fluorescence.npy </strong>contains raw fluorescence data (the F output of Suite2p data extraction). Rows are individual cells and columns are frames (i.e. timepoints) acquired at 15.253 Hz.</li> <li><strong>positions.npy </strong>contains the position of the mouse on the treadmill belt indexed from 0 to 100.</li> </ul> <p>Both NumPy(.npy) files are the output of the Preprocessing.py code, part of the analysis pipeline used for data analysis in the original publication, which can be found at <a href="https://github.com/GoncalvesLab/Frechou-et-al-Neurogenesis">https://github.com/GoncalvesLab/Frechou-et-al-Neurogenesis</a></p> <p>All imaged mice were female. Refer to the original publication for additional information. </p>
Adult neurogenesis improves spatial information encoding in the mouse hippocampus - RetroAAV-EE
<p><strong>In vivo two-photon imaging dataset for Frechou et al. "Adult neurogenesis improves spatial information encoding in the mouse hippocampus"</strong></p> <p>This dataset includes data from retro-AAV injected mice that were housed in an enriched environment (EE). </p> <p>For each recording we included raw imaging data consisting of:</p> <ul> <li>Individual frames (.tif files) from 3 consecutive 3 min Ca2+ imaging movies (which were concatenated for analysis)</li> <li>Microscope settings metadata (Experiment.xml)</li> <li>Mouse location data (Episode001.h5 in SyncData folder) containing rotary encoder and RFID data</li> </ul> <p>Some analyzed data is also included:</p> <ul> <li>Suite2p analysis data (<strong>Suite2p</strong> folder)</li> <li><strong>fluorescence.npy </strong>contains raw fluorescence data (the F output of Suite2p data extraction). Rows are individual cells and columns are frames (i.e. timepoints) acquired at 15.253 Hz.</li> <li><strong>positions.npy </strong>contains the position of the mouse on the treadmill belt indexed from 0 to 100.</li> </ul> <p>Both NumPy(.npy) files are the output of the Preprocessing.py code, part of the analysis pipeline used for data analysis in the original publication, which can be found at <a href="https://github.com/GoncalvesLab/Frechou-et-al-Neurogenesis">https://github.com/GoncalvesLab/Frechou-et-al-Neurogenesis</a></p> <p>All imaged mice in this dataset were male. Refer to the original publication for additional information. </p>
Adult neurogenesis improves spatial information encoding in the mouse hippocampus - RC
<p><strong>In vivo two-photon imaging dataset for Frechou et al. "Adult neurogenesis improves spatial information encoding in the mouse hippocampus"</strong></p> <p>This dataset includes data from mice that were housed in a regular cage (RC). </p> <p>For each recording we included raw imaging data consisting of:</p> <ul> <li>Individual frames (.tif files) from 3 consecutive 3 min Ca2+ imaging movies (which were concatenated for analysis)</li> <li>Microscope settings metadata (Experiment.xml)</li> <li>Mouse location data (Episode001.h5 in SyncData folder) containing rotary encoder and RFID data</li> </ul> <p>Some analyzed data is also included:</p> <ul> <li>Suite2p analysis data (<strong>Suite2p</strong> folder)</li> <li><strong>fluorescence.npy </strong>contains raw fluorescence data (the F output of Suite2p data extraction). Rows are individual cells and columns are frames (i.e. timepoints) acquired at 15.253 Hz.</li> <li><strong>positions.npy </strong>contains the position of the mouse on the treadmill belt indexed from 0 to 100.</li> </ul> <p>Both NumPy(.npy) files are the output of the Preprocessing.py code, part of the analysis pipeline used for data analysis in the original publication, which can be found at <a href="https://github.com/GoncalvesLab/Frechou-et-al-Neurogenesis">https://github.com/GoncalvesLab/Frechou-et-al-Neurogenesis</a></p> <p>Refer to the original publication for additional information. The sex of individual mice is as follows:</p> <table> <tbody> <tr> <td><strong>Group</strong></td> <td><strong>Mouse #</strong></td> <td><strong>Sex</strong></td> </tr> <tr> <td>RC</td> <td>M1</td> <td>M</td> </tr> <tr> <td> </td> <td>M2</td> <td>M</td> </tr> <tr> <td> </td> <td>M3</td> <td>M</td> </tr> <tr> <td> </td> <td>M4</td> <td>F</td> </tr> <tr> <td> </td> <td>M5</td> <td>F</td> </tr> </tbody> </table>
Adult neurogenesis improves spatial information encoding in the mouse hippocampus - RetroAAV-RC
<p><strong>In vivo two-photon imaging dataset for Frechou et al. "Adult neurogenesis improves spatial information encoding in the mouse hippocampus"</strong></p> <p>This dataset includes data from retro-AAV injected mice that were housed in a regular cage (RC). </p> <p>For each recording we included raw imaging data consisting of:</p> <ul> <li>Individual frames (.tif files) from 3 consecutive 3 min Ca2+ imaging movies (which were concatenated for analysis)</li> <li>Microscope settings metadata (Experiment.xml)</li> <li>Mouse location data (Episode001.h5 in SyncData folder) containing rotary encoder and RFID data</li> </ul> <p>Some analyzed data is also included:</p> <ul> <li>Suite2p analysis data (<strong>Suite2p</strong> folder)</li> <li><strong>fluorescence.npy </strong>contains raw fluorescence data (the F output of Suite2p data extraction). Rows are individual cells and columns are frames (i.e. timepoints) acquired at 15.253 Hz.</li> <li><strong>positions.npy </strong>contains the position of the mouse on the treadmill belt indexed from 0 to 100.</li> </ul> <p>Both NumPy(.npy) files are the output of the Preprocessing.py code, part of the analysis pipeline used for data analysis in the original publication, which can be found at <a href="https://github.com/GoncalvesLab/Frechou-et-al-Neurogenesis">https://github.com/GoncalvesLab/Frechou-et-al-Neurogenesis</a></p> <p>All imaged mice were male. Refer to the original publication for additional information. </p>
Intermittent Energy Restriction and Chewing on Neural Stem Cell Ageing and Adult Hippocampal Neurogenesis Associated Cognition
ClinicalTrials.gov study NCT03457870. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Data from: Development of circadian oscillators in neurosphere cultures during adult neurogenesis
Circadian rhythms are common in many cell types but are reported to be lacking in embryonic stem cells. Recent studies have described possible interactions between the molecular mechanism of circadian clocks and the signaling pathways that regulate stem cell differentiation. Circadian rhythms have not been examined well in neural stem cells and progenitor cells that produce new neurons and glial cells during adult neurogenesis. To evaluate circadian timing abilities of cells undergoing neural differentiation, neurospheres were prepared from the mouse subventricular zone (SVZ), a rich source of adult neural stem cells. Circadian rhythms in mPer1 gene expression were recorded in individual spheres, and cell types were characterized by confocal immunofluorescence microscopy at early and late developmental stages in vitro. Circadian rhythms were observed in neurospheres induced to differentiate into neurons or glia, and rhythms emerged within 3–4 days as differentiation proceeded, suggesting that the neural stem cell state suppresses the functioning of the circadian clock. Evidence was also provided that neural stem progenitor cells derived from the SVZ of adult mice are self-sufficient clock cells capable of producing a circadian rhythm without input from known circadian pacemakers of the organism. Expression of mPer1 occurred in high frequency oscillations before circadian rhythms were detected, which may represent a role for this circadian clock gene in the fast cycling of gene expression responsible for early cell differentiation.
Adult neurogenesis improves spatial information encoding in the mouse hippocampus - hM4Di Silencing
<p><strong>In vivo two-photon imaging dataset for Frechou et al. "Adult neurogenesis improves spatial information encoding in the mouse hippocampus"</strong></p> <p>This dataset includes data from CNO-induced chemogenetic silencing experiments in hM4Di+ and hM4Di-(control) mice. There is another Zenodo dataset with the remaining hM4Di-(control) mice <a href="https://doi.org/10.5281/zenodo.10949624">here</a>. The folder for each mouse includes baseline (pre) and post-CNO (cno) recordings.</p> <p>For each recording we included raw imaging data consisting of:</p> <ul> <li>Individual frames (.tif files) from 3 consecutive 3 min Ca2+ imaging movies (which were concatenated for analysis)</li> <li>Microscope settings metadata (Experiment.xml)</li> <li>Mouse location data (Episode001.h5 in SyncData folder) containing rotary encoder and RFID data</li> </ul> <p>Some analyzed data is also included:</p> <ul> <li>Suite2p analysis data (<strong>Suite2p</strong> folder)</li> <li><strong>fluorescence.npy </strong>contains raw fluorescence data (the F output of Suite2p data extraction). Rows are individual cells and columns are frames (i.e. timepoints) acquired at 15.253 Hz.</li> <li><strong>positions.npy </strong>contains the position of the mouse on the treadmill belt indexed from 0 to 100.</li> </ul> <p>Both NumPy(.npy) files are the output of the Preprocessing.py code, part of the analysis pipeline used for data analysis in the original publication, which can be found at <a href="https://github.com/GoncalvesLab/Frechou-et-al-Neurogenesis">https://github.com/GoncalvesLab/Frechou-et-al-Neurogenesis</a></p> <p>Refer to the original publication for additional information. The sex of individual mice is as follows:</p> <p> </p> <table> <tbody> <tr> <td><strong>Group</strong></td> <td><strong>Mouse #</strong></td> <td><strong>Sex</strong></td> <td><strong>Group</strong></td> <td><strong>Mouse #</strong></td> <td><strong>Sex</strong></td> </tr> <tr> <td>hM4Di+</td> <td>M1</td> <td>M</td> <td>hM4Di-</td> <td>M1</td> <td>M</td> </tr> <tr> <td> </td> <td>M2</td> <td>M</td> <td> </td> <td>M2</td> <td>M</td> </tr> <tr> <td> </td> <td>M3</td> <td>F</td> <td> </td> <td>M3</td> <td>M</td> </tr> <tr> <td> </td> <td>M4</td> <td>F</td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> </td> <td>M5</td> <td>M</td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> </td> <td>M6</td> <td>M</td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> </td> <td>M7</td> <td>M</td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> </td> <td>M8</td> <td>F</td> <td> </td> <td> </td> <td> </td> </tr> <tr> <td> </td> <td>M9</td> <td>F</td> <td> </td> <td> </td> <td> </td> </tr> </tbody> </table>
Data from: Development of circadian oscillators in neurosphere cultures during adult neurogenesis
Open the record for dataset details and reuse information.
The meninges host a unique compartment of regulatory T cells that bulwarks adult hippocampal neurogenesis [scRNA-Seq]
GEO Series GSE234315. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Polycomb Repressive Complex 2 regulates basal cell fate during adult olfactory neurogenesis [ChIP-seq]
GEO Series GSE224892. Mus musculus. 7 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Microglia actively remodels adult hippocampal neurogenesis through the phagocytosis secretome
GEO Series GSE129569. Mus musculus. 9 samples. Type: Expression profiling by array.
De novo DNA methylation controls neuronal maturation during adult hippocampal neurogenesis.
GEO Series GSE167955. Mus musculus. 653 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
The impact of conditional Opa1 Knockout on gene expression profile at single cell level during adult neurogenesis in the hippocampus
GEO Series GSE233461. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
SETD4 Cells Contribute to Brain Development and Maintain Adult Stem Cell Reservoir for Neurogenesis
GEO Series GSE200159. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
AAV-mediated expression of proneural factors stimulates neurogenesis from adult Müller glia in vivo.
GEO Series GSE285980. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.