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44 results for “advanced glycation end products”
Advanced Glycation End-products are Retained in Decellularized Muscle Matrix Derived from Aged Skeletal Muscle
<p>Advanced glycation end-products (AGEs) accrue on skeletal muscle collagen in old age, stiffening the matrix and increasing inflammation. Whether decellularized biomaterials derived from aged muscle would suffer from increased AGE cross-links is unknown. We hypothesized that DMM from old muscle would have increased collagen, collagen cross-linking, stiffness, and AGEs. We isolated, decellularized, and characterized gastrocnemii of 1-month, 2-month, and 20-month old C57BlJ6 mice to determine age-dependent changes to collagen in muscle and decellularized muscle matrix (DMM). Total hydroxyproline and soluble hydroxyproline after proteinase K digestion were measured to assay collagen levels and cross-linking, respectively. Muscle fiber and DMM stiffness was determined using atomic force microscopy (AFM). AGE ELISAs were used to test AGE levels, and the effect of AGE cross-link breaker ALT-711 on DMM was tested. We determined age-dependent increases in collagen amount, cross-linking, and general stiffness are retained on DMM. DMM from old muscle was stiffer compared to younger groups according to shifts in AFM modulus distribution. We measured an increase in AGE-specific cross-links with old age in whole muscle and observed that these changes are countered in DMM by AGE cross-link breaker ALT-711. Future study investigating and countering the biological effects of old age on DMM is warranted.</p>
Role of the Interaction Between Advanced Glycation End Products and Their Receptor RAGE in the Development and the Progression of the Uremic Vasculopathy of Hemodialyzed Patients
ClinicalTrials.gov study NCT02818465. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Dietary Advanced Glycation End-products and Insulin Resistance in Overweight and Obese Humans
ClinicalTrials.gov study NCT00422253. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Serum Levels of Advanced Glycation End-products After Dietary Intervention in Hypertensive Patients
ClinicalTrials.gov study NCT02848677. IPD Sharing: NO. Countries: 1. Publications: 16.
Effect of Whole Grain Diet on Insulin Sensitivity, Advanced Glycation End Products and Inflammatory Markers in Pre-diabetes
ClinicalTrials.gov study NCT01248286. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Evaluation of Advanced Glycation End-products (AGE) and the Erectile Dysfunction (DE) in Diabetic Patients
ClinicalTrials.gov study NCT02770235. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Impact of FTO Gene Variation on Body Composition, Lipid Profile, Insulin Resistance, Advanced Glycation End-Products and Ghrelin Levels in Response to Hypocaloric, Protein Rich-Diet
ClinicalTrials.gov study NCT06426017. IPD Sharing: NO. Countries: 1. Publications: 4.
Pilot Study of a Dietary Intervention Based Upon Advanced Glycation End Products
ClinicalTrials.gov study NCT01402973. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Investigating the Link Between Advanced Glycation End Products (AGEs) and Muscle Wasting in Sarcobesity
ClinicalTrials.gov study NCT06438900. IPD Sharing: NO. Countries: 1. Publications: 23.
Effect of Glucose Load on Expression of Advanced Glycation End Products in Women Screened for Gestational Diabetes
ClinicalTrials.gov study NCT03029546. IPD Sharing: NO. Countries: 1. Publications: 2.
Dietary Advanced Glycation End Products, Inflammation and Oxidative Stress in Breast Cancer Patients
ClinicalTrials.gov study NCT04716764. IPD Sharing: Not stated. Countries: 1. Publications: 11.
Effect of a Low Advanced Glycation End Products (AGE) Diet in the Metabolic Syndrome
ClinicalTrials.gov study NCT01363141. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Soluble Advanced Glycation End Product (sRAGE) Levels
ClinicalTrials.gov study NCT06771986. IPD Sharing: NO. Countries: 1. Publications: 1.
Advanced Glycation End Products and Dietary Intervention in Polycystic Ovary Patients
ClinicalTrials.gov study NCT05830487. IPD Sharing: NO. Countries: 1. Publications: 1.
Dietary Advanced Glycation End Products and Migraine
ClinicalTrials.gov study NCT05747911. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: Characterization of advanced glycation end products and their receptor (RAGE) in an animal model of myocardial infarction
Circulating advanced glycation end products (AGE) and their receptor, RAGE, are increased after a myocardial infarction (MI) episode and seem to be associated with worse prognosis in patients. Despite the increasing importance of these molecules in the course of cardiac diseases, they have never been characterized in an animal model of MI. Thus, the aim of this study was to characterize AGE formation and RAGE expression in plasma and cardiac tissue during cardiac remodeling after MI in rats. Adult male Wistar rats were randomized to receive sham surgery (n = 15) or MI induction (n = 14) by left anterior descending coronary artery ligation. The MI group was stratified into two subgroups based on postoperative left ventricular ejection fraction: low (MIlowEF) and intermediate (MIintermEF). Echocardiography findings and plasma levels of AGEs, protein carbonyl, and free amines were assessed at baseline and 2, 30, and 120 days postoperatively. At the end of follow-up, the heart was harvested for AGE and RAGE evaluation. No differences were observed in AGE formation in plasma, except for a decrease in absorbance in MIlowEF at the end of follow-up. A decrease in yellowish-brown AGEs in heart homogenate was found, which was confirmed by immunodetection of N-ε-carboxymethyl-lysine. No differences could be seen in plasma RAGE levels among the groups, despite an increase in MI groups over the time. However, MI animals presented an increase of 50% in heart RAGE at the end of the follow-up. Despite the inflammatory and oxidative profile of experimental MI in rats, there was no increase in plasma AGE or RAGE levels. However, AGE levels in cardiac tissue declined. Thus, we suggest that the rat MI model should be employed with caution when studying the AGE-RAGE signaling axis or anti-AGE drugs for not reflecting previous clinical findings.
Exercise and the Receptor for Advanced Glycation End Products (RAGE)
ClinicalTrials.gov study NCT03534687. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Skin Autofluorescence Assessment of Advanced Glycation End Products in Rheumatic Diseases
ClinicalTrials.gov study NCT07329556. IPD Sharing: UNDECIDED. Countries: 0. Publications: 1.
Vitamin D Increases Serum Levels of the Soluble Receptor for Advanced Glycation End Products in Women With PCOS
ClinicalTrials.gov study NCT03644212. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Receptor for Advanced Glycation End Products (RAGE) Polymorphisms In Inflammatory Bowel Disease
ClinicalTrials.gov study NCT04286659. IPD Sharing: Not stated. Countries: 0. Publications: 10.
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