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1,540 results for “anemia”
A minimal Fanconi Anemia complex in Early Diverging Fungi
<p>This dataset provides all the raw data used in the<strong> A minimal Fanconi Anemia complex in Early Diverging Fungi </strong>manuscript including:</p> <p><strong>Supplementary Table S1.</strong></p> <p>All protein identifiers, genomic assemblies, transcriptomic datasets, hypergeometric test values</p> <p><strong>Supplementary Materials SM1</strong></p> <p>The figures of phylogenetic trees for FA proteins.</p> <p><strong>Supplementary Dataset SD1.</strong></p> <p>The phylogenetic trees for FA proteins as a newick file format.</p>
Data for Age and socioeconomic status in relation to risk of maternal anemia among the Ariaal of northern Kenya
<p>Data used for a paper entitled, "Age and socioeconomic status in relation to risk of maternal anemia among the Ariaal agropastoralists of northern Kenya"</p>
A cost effectiveness analysis on interventions for childhood anemia in developing countries: A health technology assessment
<p>This is a data sheet of the "A cost-effectiveness analysis on interventions for childhood anemia in developing countries: A health technology assessment" used in the study. </p>
Rps19 R67∆ mutation creates a model of Diamond-Blackfan anemia and reveals downstream mediators of p53 pathway.
<p>Diamond-Blackfan anemia (DBA) is a rare bone marrow failure syndrome accompanied by cardiovascular, skeletal, and urogenital abnormalities. Most of the affected individuals carry mutations in ribosomal proteins, including S19 (Rps19), a part of the 40S ribosomal subunit. We developed a transgenic model harboring deletion of conserved Arg 67 in <em>RPS19</em>, which is the site of post-translational modification by protein-arginine methyl transferase family and could show that the defect in Rps19 causes phenotype in perfect overlap with the DBA including hematologic dysfunctions, hypotrophy, intrinsic anemia, severe craniofacial, skeletal, urogenital, cardiovascular, and cerebral abnormalities leading to premature lethality during the adolescence of the mouse. This DBA mouse model exhibited activation of the Trp53 signaling pathway in hematopoietic stem cells (HSCs) leading to reduced erythroid lineage development. Competitive transplantation assays using Rps19-deficient bone marrow cells confirmed that HSCs and their progeny lineages were affected while their differentiation was rescued after inactivation of the tumor suppressor Trp53 showing that the development of the DBA phenotype significantly involves non-canonical components of the p53 signaling pathway in the etiopathogenesis of DBA with the Rps19R67∆ mutation leading to the disrupted hematopoietic hierarchy starting at the stage of short-term repopulating stem cells. The activated p53 pathway was mediated by downstream molecules Zmat3, Phlda3, and Eda2r, whose overall function in the pathology of DBA involve erythroid differentiation blockade coupled with cell proliferation and survival disruption. To conclude, the new DBA model represents a powerful tool for exploring new therapeutic options for DBA.</p>
Study of Efficacy and Safety of Twice Daily Oral LNP023 in Adult PNH Patients With Residual Anemia Despite Anti-C5 Antibody Treatment
ClinicalTrials.gov study NCT04558918. IPD Sharing: YES. Countries: 12. Publications: 3.
Study Assessed the Safety and Efficacy of Eltrombopag in Chinese Refractory or Relapsed Severe Aplastic Anemia (SAA) Subjects.
ClinicalTrials.gov study NCT03988608. IPD Sharing: YES. Countries: 1. Publications: 1.
INCB000928 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Anemia Due to Myeloproliferative Disorders
ClinicalTrials.gov study NCT04455841. IPD Sharing: YES. Countries: 6. Publications: 0.
Study of Efficacy, Safety and Tolerability of ACZ885 (Canakinumab) in Pediatric and Young Adult Patients With Sickle Cell Anemia
ClinicalTrials.gov study NCT02961218. IPD Sharing: YES. Countries: 7. Publications: 1.
Active Preoperative Anemia Management in Patients Undergoing Cardiac Surgery
ClinicalTrials.gov study NCT02189889. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Single-cell profiling of human bone marrow progenitors reveals mechanisms of failing erythropoiesis in Diamond-Blackfan anemia
<p>Ribosome dysfunction underlies the pathogenesis of many cancers and heritable ribosomopathies. Here we investigate how mutations in either ribosomal protein large (RPL) or ribosomal protein small (RPS) subunit genes selectively affect erythroid progenitor development and clinical phenotypes in Diamond-Blackfan anemia (DBA), a rare ribosomopathy with limited therapeutic options. Using single-cell assays of patient-derived bone marrow, we delineated two distinct cellular trajectories segregating with ribosomal protein genotypes: almost complete loss of erythroid specification were observed in <em>RPS</em>-DBA. In contrast, we observed relative preservation of qualitatively abnormal erythroid progenitors and precursors in <em>RPL</em>-DBA. Although both DBA genotypes exhibited a pro-inflammatory bone marrow milieu, <em>RPS</em>-DBA was characterized by erythroid differentiation arrest, whereas <em>RPL</em>-DBA was characterized by preserved GATA1 expression and activity. Compensatory stress erythropoiesis in <em>RPL</em>-DBA exhibited disordered differentiation underpinned by an altered glucocorticoid molecular signature, including reduced <em>ZFP36L2</em> expression<em>,</em> leading to milder anemia and improved corticosteroid response. This integrative analysis approach identified distinct pathways of erythroid failure and defined genotype-phenotype correlations in DBA. These findings may help facilitate therapeutic target discovery.</p> <p> </p>
Nagaur_Data File_Anemia in Pregnancy_CSV.csv
<p><a href="https://zenodo.org/api/files/7001b1e5-bf39-4955-9fea-8e27a8a2bcb4/Nagaur_Data%20File_Anemia%20in%20Pregnancy_CSV.csv">Nagaur_Data File_Anemia in Pregnancy_CSV.csv</a></p>
Jodhpur_Data File_anemia in Pregnancy_CSV.csv
<p><a href="https://zenodo.org/api/files/03147c6f-ffc6-4091-9a68-6945315e7115/Jodhpur_Data%20File_anemia%20in%20Pregnancy_CSV.csv">Jodhpur_Data File_anemia in Pregnancy_CSV.csv</a></p>
Anemia Studies in Chronic Kidney Disease: Erythropoiesis Via a Novel Prolyl Hydroxylase Inhibitor Daprodustat-Non-Dialysis (ASCEND-ND)
ClinicalTrials.gov study NCT02876835. IPD Sharing: YES. Countries: 39. Publications: 5.
20-Week Repeat Oral Dose Study of AKB-6548 in Participants With Chronic Kidney Disease and Anemia
ClinicalTrials.gov study NCT01906489. IPD Sharing: NO. Countries: 1. Publications: 2.
Safety & Efficacy of Peginesatide for the Treatment of Anemia in Participants With Chronic Renal Failure Not on Dialysis
ClinicalTrials.gov study NCT00598273. IPD Sharing: Not stated. Countries: 2. Publications: 2.
A Trial Comparing Ferumoxytol With Placebo for the Treatment of Iron Deficiency Anemia
ClinicalTrials.gov study NCT01114139. IPD Sharing: Not stated. Countries: 6. Publications: 1.
Study to Evaluate the Efficacy, Safety and Pharmacokinetics of Three-times Weekly Dosing of GSK1278863 in Hemodialysis-dependent Subjects With Anemia Associated With Chronic Kidney Disease Who Are Swi
ClinicalTrials.gov study NCT02689206. IPD Sharing: YES. Countries: 5. Publications: 2.
4 Week Correction Study in Subjects With Anemia Associated With Chronic Kidney Disease Who Are Not Undergoing Dialysis
ClinicalTrials.gov study NCT01587898. IPD Sharing: YES. Countries: 3. Publications: 2.
Does a Daily Iron Tablet Improve Anemia in Cystic Fibrosis
ClinicalTrials.gov study NCT01755455. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy and Safety of Roxadustat for Treatment of Anemia in Participants With Lower Risk Myelodysplastic Syndrome With Low Red Blood Cell Transfusion Burden
ClinicalTrials.gov study NCT03263091. IPD Sharing: NO. Countries: 16. Publications: 1.
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International Brain Laboratory public data
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OpenNeuro
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