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1,046 results for “anti-inflammatories”
An inflamed human alveolar model for testing the efficiency of anti-inflammatory drugs in vitro
<p>The data set accompanies the study where we developed an inflamed human alveolar epithelium model and to test the resolution<strong><em> </em></strong>lipopolysaccharide (LPS)-induced inflammation <em>in vitro</em> with a corticosteroid, methylprednisolone (MP). A specific focus of the study was in macrophage phenotype shifts in response to these stimuli.</p> <p>The data set includes:</p> <p>- Pro-inflammatory marker (interleukin (IL)-8, tumor necrosis factor α (TNFα), IL1β) secretion data, analysed via ELISA, and cell viability (analysed via lactate dehydrogenase assay) of both monocultures (human monocyte-derived macrophages) and of the multicellular human alveolar model, composed of macrophages, dendritic cells, and epithelial cells. </p> <p>- Barrier permeability data of the multicellular model, assessed via labeled-dextran permeability assay. </p> <p>All the above-stated data is joined in the file: DraslerB_Frontiers 2020_Inflammatory model. Sample codes are explained int he first tabs. </p> <p>- Pro-inflammatory marker gene expression data of the multicellular model, assessed via real time RT-qPCR. The data prepared for analysis and analysed is joined to the above-mentioned folder, whereas the direct PCR runs are joined in the file: DraslerB_Frontiers 2020_Inflammatory model_PCR runs. </p> <p>- Confocal laser scanning microscopy raw files (lsm) of the multicellular model can be opened with an open source software Fiji, based on ImageJ. </p>
Multi-omics data for pro-inflammatory and anti-inflammatory exposure to THP-1 macrophages
<p>This data characterizes gene expression levels in THP-1 macrophages. The data was generated using RNA sequencing and analyzed with DeSeq2 (version 1.24.0). The analysis included raw count data and normalized count matrices obtained from DESeq2's dds_deseq objects.<br>This data describes the methylation levels of individual CpG sites in THP-1 macrophages. The data was obtained using the Infinium MethylationEPIC v2.0 Kit (Illumina) and analyzed with the minfi package (version 1.46). Specifically, the data underwent quantile normalization using the preprocessQuantile function within minfi. Only CpG sites with a detection p-value less than 0.05 were included to obtain MatrixProcessedGEO.txt file. The beta values (bValues.xlsx) were obtained using the function “getBeta” from the same package, considering each time point individually.<br>The macrophages were exposed to phorbol 12-myristate 13-acetate (PMA) for 48 hours, followed by treatment with either a combination of LPS (10 pg/ml) and interferon-gamma (IFNγ) (20 ng/ml) or a combination of interleukins 13 (IL-13) (20 ng/ml) and 4 (IL-4) (20 ng/ml) for 24, 48, and 72 hours.</p>
Anti-inflammatory compounds in probiotic yeast revealed by untargeted metabolomics
<p><strong>Abstract</strong></p> <p>The saccharomyces strain <em>Saccharomyces cerevisiae </em>var.<em> boulardii</em> has exhibited efficacy in ameliorating symptoms of gastrointestinal disorders, including inflammatory diseases. The molecular origin of the anti-inflammatory activity has remained largely elusive to this day. Earlier studies suggest a small, secreted, yet undefined, molecule as the active principle and thus an untargeted metabolomics approach towards its identification was adopted. We used LCMS-analysis to interrogate the secreted metabolome of <em>S. cerevisiae </em>var.<em> boulardii</em> in comparison to a <em>S. cerevisiae </em>reference strain. Statistical analysis of the data revealed several compounds unique to <em>S. cerevisiae </em>var.<em> boulardii</em>, that were partially annotated and confirmed by comparison with authentic standards. Furthermore, anti-inflammatory properties were experimentally assigned to several small molecules, indicating that this property of the yeast variant is due to several factors. Our data suggest that the anti-inflammatory properties of <em>S. cerevisiae </em>var.<em> boulardii</em> can be linked to the activity of small molecules in its secreted metabolome.</p>
Figure 5 in Antinociceptive and anti-inflammatory activities of Hymenaea martiana Hayne (Fabaceae) in mice
Figure 5. Effect of the ethyl acetate fraction of Hymenaea martiana (Hm-AcOEt - 100, 200 and 400 mg.kg-1), indomethacin (20 mg. kg-1) and morphine (10 mg.kg-1) on formalin test in mice. Values are mean ± S.E.M.; **P <0.01, significantly different from control; one-way ANOVA followed by Tukey's test (n = 6, per group). (a) first phase and (b) second phase.
Figure 7 in Antinociceptive and anti-inflammatory activities of Hymenaea martiana Hayne (Fabaceae) in mice
Figure 7. Effect of the ethyl acetate fraction of Hymenaea martiana (Hm-AcOEt - 100, 200 and 400 mg.kg-1), Hm-EtOH (200 mg.kg-1) + naloxone and morphine (10 mg.kg-1) on the hot-plate test in mice. Values are mean ± S.E.M.; *P <0.05, **P <0.01, significantly different from control; two-way ANOVA followed by Bonferroni's multiple comparisons test (n = 6, per group).
Figure 6 in Antinociceptive and anti-inflammatory activities of Hymenaea martiana Hayne (Fabaceae) in mice
Figure 6. Effect of the ethanolic extract of Hymenaea martiana (Hm-EtOH - 100, 200 and 400 mg.kg-1), Hm-EtOH (200 mg.kg-1) + naloxone and morphine (10 mg.kg-1) in the hot-plate test in mice. Values are mean ± S.E.M.; *P <0.05, ** P <0.01, significantly different from control; two-way ANOVA followed by Bonferroni's multiple comparisons test (n = 6, per group).
Figure 11 in Antinociceptive and anti-inflammatory activities of Hymenaea martiana Hayne (Fabaceae) in mice
Figure 11. Effect of the ethyl acetate fraction of Hymenaea martiana (Hm-AcOEt - 100, 200 and 400 mg.kg-1) and dexamethasone (2 mg. kg-1) on leukocyte migration into the peritoneal cavity induced by carrageenan in mice. Values are mean ± S.E.M.; **P <0.01, significantly different from control; one-way ANOVA followed by Tukey's test (n = 6, per group).
Figure 10 in Antinociceptive and anti-inflammatory activities of Hymenaea martiana Hayne (Fabaceae) in mice
Figure 10. Effect of the ethanolic extract of Hymenaea martiana (Hm-EtOH - 100, 200 and 400 mg.kg-1) and dexamethasone (2 mg. kg-1) on leukocyte migration into the peritoneal cavity induced by carrageenan in mice. Values are mean ± S.E.M.; **P <0.01, significantly different from control; ANOVA one-way followed by Tukey's test (n = 6, per group).
Figure 9 in Antinociceptive and anti-inflammatory activities of Hymenaea martiana Hayne (Fabaceae) in mice
Figure 9. Effect of the ethyl acetate fraction of Hymenaea martiana (Hm-AcOEt - 100, 200 and 400 mg.kg-1) and indomethacin (20 mg. kg-1) on carrageenan-induced hind paw edema in mice. Values are mean ± S.E.M.; *P <0.05, **P <0.01, significantly different from control; two-way ANOVA followed by Bonferroni's multiple comparisons test (n = 6, per group).
Inflammation-controlled anti-inflammatory hydrogels
<p>Dataset to the publication</p> <p><strong>Inflammation-controlled anti-inflammatory hydrogels</strong></p> <p>Tina Helmecke, Dominik Hahn, Nadine Matzke, Lisa Ferdinand, Lars Franke, Sebastian Kühn, Gunter Fischer, Carsten Werner, Manfred F. Maitz</p> <p>Advanced Science 2022, 2206412. <a href="https://doi.org/10.1002/advs.202206412">https://doi.org/10.1002/advs.202206412</a></p>
Advancements in QSAR modelling: Decision trees and rotation forest for prediction of Aspergillus anti-inflammatory metabolites
<p>This study presents applications of advancements in QSAR modelling for predicting nitric oxide (NO) inhibitors and anti-inflammatory metabolites from the <em>Aspergillus</em> genus. Inflammation-related diseases remain a pressing concern, necessitating the identification of effective anti-inflammatory compounds. Using decision trees, the Ranker method, and CorrelationAtrributeEval as a base classifier for attribute selection together with Rotation Forest and Adaboost as enhancers, we explored their potential with different classifiers including Artificial Neural Networks and J48 Trees. The proposed QSAR models employed an ensemble approach with Rotation Forest and Adaboost.M1, applying an automated KNIME workflow. Seven molecular descriptors were selected and trained on a comprehensive dataset of diverse anti-inflammatory <em>Aspergillus</em> specialised metabolites. Results showed that the Rotation Forest-enhanced version outperformed other models, capturing complex structure-activity relationships and improving predictive performance. Chemical characteristics of electrotopological state, topological distances, and functional groups including secondary amides and alcohols contribute to important anti-inflammatory effects. The developed QSAR model showed good predictive performance for anti-inflammatory <em>Aspergillus</em> metabolites, focusing on their NO inhibitory activity. These results can contribute to the discovery of novel anti-inflammatory drugs based on computational techniques.</p> <p> </p>
Study to Examine the Clinical Efficacy and the Nonsteroidal Anti-inflammatory Drug (NSAID)-Sparing Effect of Secukinumab Over 16 Weeks in Patients With Ankylosing Spondylitis
ClinicalTrials.gov study NCT02763046. IPD Sharing: YES. Countries: 1. Publications: 1.
Special Drug Use Surveillance of Vonoprazan for "Prevention of Recurrence of Gastric/Duodenal Ulcer in Patients Receiving Non-steroidal Anti-inflammatory Drugs: Long-term Use"
ClinicalTrials.gov study NCT03214198. IPD Sharing: YES. Countries: 1. Publications: 1.
Vizgen MERFISH files for Single-cell analysis reveals M. tuberculosis ESX-1-mediated accumulation of anti-inflammatory macrophages in infected mouse lungs
Open the record for dataset details and reuse information.
Single-cell analysis reveals M. tuberculosis ESX-1-mediated accumulation of anti-inflammatory macrophages in infected mouse lungs
Open the record for dataset details and reuse information.
Datasheet of Anti-Inflammatory Activity and Toxicity Evaluation of 1,3-bis(p-Hydroxyphenyl)urea
<p><strong>Background: </strong>Inflammation is a normal protective response caused by an injury or tissue damage, through physical trauma, damaging chemicals, or invasion of pathogenic microorganisms. One of the modified <em>p</em>-aminophenol compounds is 1,3-bis(<em>p</em>-hydroxyphenyl)urea, which was estimated to have more potent analgesic activity and fewer hepatotoxic side effects than paracetamol. When the lipophilicity of this compound increases between 1.8 to 4.4, it is observed to serve as an anti-inflammatory agent. Therefore, the determination of safety precaution is very necessary while testing for the toxicity effect of 1,3-bis(<em>p</em>-hydroxyphenyl)urea. This is due to the effectiveness and safety of suitable drugs.</p> <p><strong>Methods: </strong>An anti-inflammatory test was carried out by measuring the percentage of inflammation in rats, after the administration of 1,3-bis(<em>p</em>-hydroxyphenyl)urea was previously induced by the carrageenan solution intraplantar and the analysis of neutrophil values through a plethysmometer and Hematoxylin-Eosin method. Also, an acute toxicity test was performed by administering this p-aminophenol compound to female rats for 24 h and observed for 14 days. In addition, a subchronic toxicity test was conducted on male and female rats for 28 days, with continuous observations carried out for 42 days.</p> <p><strong>Results: </strong>The doses of 1,3-bis(<em>p</em>-hydroxyphenyl)urea at 50, 100, and 200 mg/Kg BW, had anti-inflammatory activity compared to diclofenac sodium at 2.25 mg/Kg BW. Also, there is no toxicity and animal death symptoms were observed in the acute and subchronic tests.</p> <p><strong>Conlclusion: </strong>This 1,3-bis(<em>p</em>-hydroxyphenyl)urea compound had an anti-inflammatory activity and relatively low toxicity.</p>
Datasheet of Anti-Inflammatory Activity and Toxicity Evaluation of 1,3 bis(p-Hydroxyphenyl)urea
<p><strong>Background: </strong>Inflammation is a normal protective response caused by an injury or tissue damage, through physical trauma, damaging chemicals, or invasion of pathogenic microorganisms. One of the modified p-aminophenol compounds is 1,3 bis (p-Hydroxyphenyl) urea, which was estimated to have more potent analgesic activity and fewer hepatotoxic side effects than paracetamol. When the lipophilicity of this compound increases between 1.8 to 4.4, it is observed to serve as an an- ti-inflammatory agent. Therefore, the determination of safety precaution is very necessary while testing for the toxicity effect of 1,3 bis (p-Hydroxyphenyl) urea. This is due to the effectiveness and safety of suitable drugs.</p> <p><strong>Methods: </strong>An anti-inflammatory test was carried out by measuring the per-centage of inflammation in rats, after the administration of 1,3 bis (p-Hydroxyphenyl) urea was previously induced by the carrageenan solution intraplantar and the analy- sis of neutrophil values through a plethysmometer and Hematoxylin-Eosin method. Also, an acute toxicity test was performed by administering this p-aminophenol com- pound to female rats for 24 h and observed for 14 days. In addition, a subchronic toxicity test was conducted on male and female rats for 28 days, with continuous observations carried out for 42 days.</p> <p><strong>Results:</strong>The doses of 1,3 bis (p-Hydroxyphenyl) urea at 50, 100, and 200 mg/Kg BW, had anti-inflammatory activity compared to diclofenac sodium at 2.25 mg/Kg BW. Also, there is no toxicity and animal death symp-toms were observed in the acute and subchronic tests.</p> <p><strong>Conlclusion:</strong>This p-aminophenol compound had an anti-inflammatory activity and relatively low toxicity.</p>
Author list of Anti-Inflammatory Activity and Toxicity Evaluation of 1,3-bis(p-Hydroxyphenyl)urea
<p><strong>Background: </strong>Inflammation is a normal protective response caused by an injury or tissue damage, through physical trauma, damaging chemicals, or invasion of pathogenic microorganisms. One of the modified <em>p</em>-aminophenol compounds is 1,3-bis(<em>p</em>-hydroxyphenyl)urea, which was estimated to have more potent analgesic activity and fewer hepatotoxic side effects than paracetamol. When the lipophilicity of this compound increases between 1.8 to 4.4, it is observed to serve as an anti-inflammatory agent. Therefore, the determination of safety precaution is very necessary while testing for the toxicity effect of 1,3-bis(<em>p</em>-hydroxyphenyl)urea. This is due to the effectiveness and safety of suitable drugs.</p> <p><strong>Methods: </strong>An anti-inflammatory test was carried out by measuring the percentage of inflammation in rats, after the administration of 1,3-bis(<em>p</em>-hydroxyphenyl)urea was previously induced by the carrageenan solution intraplantar and the analysis of neutrophil values through a plethysmometer and Hematoxylin-Eosin method. Also, an acute toxicity test was performed by administering this p-aminophenol compound to female rats for 24 h and observed for 14 days. In addition, a subchronic toxicity test was conducted on male and female rats for 28 days, with continuous observations carried out for 42 days.</p> <p><strong>Results: </strong>The doses of 1,3-bis(<em>p</em>-hydroxyphenyl)urea at 50, 100, and 200 mg/Kg BW, had anti-inflammatory activity compared to diclofenac sodium at 2.25 mg/Kg BW. Also, there is no toxicity and animal death symptoms were observed in the acute and subchronic tests.</p> <p><strong>Conlclusion: </strong>This 1,3-bis(<em>p</em>-hydroxyphenyl)urea compound had an anti-inflammatory activity and relatively low toxicity.</p>
Anti-inflammatory and anti-bacterial potentials of mulberry leaf extract on oral microorganisms
<p>This is supplementary files for main manuscript "Anti-inflammatory and anti-bacterial potentials of mulberry leaf extract on oral microorganisms"</p>
Data from: Vaginal lactobacilli produce anti-inflammatory beta-carboline (BC) compounds. RNAseq dataset of BC-treated human monocytes.
<p>Primary human monocytes were isolated from peripheral blood mononuclear cells via CD14+ magnetic selection. Monocytes were then treated with 3 beta-carboline compounds isolated from the supernatant of vaginal <em>Lactobacillus crispatus</em> strain MV-1A-US (HM-637). The beta-carbolines are labled 322/BC1; 325/BC3 and 361/BC6. We find that BC6 suppresses inflammatory signaling genes in untreated and in LPS-treated monocytes. FIles include raw reads, count table and code for DESeq2-generated differentially expressed genes. </p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.