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11 results for “antibiotic adjuvant”
Antibiotics as an Adjuvant in Patients With Acute Severe Ulcerative Colitis
ClinicalTrials.gov study NCT03794765. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Data from: Modified antibiotic adjuvant ratios can slow and steer the evolution of resistance: Co-amoxiclav as a case study
As antibiotic resistance spreads, developing sustainable methods to restore the efficacy of existing antibiotics is increasingly important. One widespread method is to combine antibiotics with synergistically acting adjuvants that inhibit resistance mechanisms, allowing drug killing. Here we use co-amoxiclav (a clinically important combination of the -lactam antibiotic amoxicillin and the -lactamase inhibitor clavulanate) to ask whether treatment efficacy and resistance evolution can be decoupled via component dosing modifications. A simple mathematical model predicts that different ratios of these two drug components can produce distinct evolutionary responses irrespective of initial efficacy. We test this hypothesis by selecting Escherichia coli with a plasmid encoded -lactamase (CTX-M-14), against different compositions of amoxicillin and clavulanate. Consistent with our theory, we found that while resistance evolved under all conditions, the component ratio influenced both the rate and mechanism of resistance evolution. Specifically, we found that the current clinical practice of high amoxicillin to clavulanate ratios resulted in the most rapid adaptation to antibiotics via gene dosing responses. Increased plasmid copy number allowed E. coli to increase -lactamase dosing and effectively titrate out low quantities of clavulanate, restoring amoxicillin resistance. In contrast, high clavulanate ratios were more robust - plasmid copy number did not increase, although porin or efflux resistance mechanisms were found, as in all drug ratios. Our results indicate that by changing the ratio of adjuvant to antibiotic we can slow and steer the path of resistance evolution. We therefore suggest using increased adjuvant dosing regimens to slow the rate of resistance evolution.
Data from: Modified antibiotic adjuvant ratios can slow and steer the evolution of resistance: Co-amoxiclav as a case study
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Brominated carbazole's antibiotic adjuvant effects in MRSA 43300
GEO Series GSE193395. Staphylococcus aureus. 12 samples. Type: Expression profiling by high throughput sequencing.
A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics
GEO Series GSE280093. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
To Evaluate the Effects of Systemic Probiotics & Antibiotics and Local Application of Antibiotics As an Adjuvant to NSPT
ClinicalTrials.gov study NCT06570863. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Antibiotic and Probiotic Therapies in the Adjuvant Treatment of the Chronic Periodontitis.
ClinicalTrials.gov study NCT03692819. IPD Sharing: NO. Countries: 1. Publications: 0.
Assessment of the Adjuvant Role of Dietary Supplementation of Antibiotic-tolerant Probiotics in Standard Therapy for the Eradication of Helicobacter Pylori Infection.
ClinicalTrials.gov study NCT06499649. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Loratadine's antibiotic adjuvant effects in MRSA 43300
GEO Series GSE227099. Staphylococcus aureus. 12 samples. Type: Expression profiling by high throughput sequencing.
Antibiotic adjuvant effects in MRSA USA300
GEO Series GSE291913. Staphylococcus aureus. 18 samples. Type: Expression profiling by high throughput sequencing.
Antibiotic adjuvant effects in VRSA-1
GEO Series GSE308438. Staphylococcus aureus. 25 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.