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215
datasets available to search
ShareScore release 0.9.0
Dataset results
215 results for “antigen presentation”
Effect of Methyldopa on MHC Class II Antigen Presentation in Type 1 Diabetes
ClinicalTrials.gov study NCT01883804. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A molecular basis for the presentation of phosphorylated peptides by HLA-B antigens (ANNOTATED MS2 SPECTRA OF PHOSPHOPEPTIDES)
<p>Phosphopeptides identified from the immunopeptidome of the C1R-B*40 cell line. </p> <p>Phosphopeptides identified from the proteome of the C1R-B*40 cell line. </p> <p>Phosphopeptides identified from the immunopeptidome of the GR cell line. </p>
CLEC-1 is a death sensor that limits antigen cross-presentation by dendritic cells and represents a target for cancer immunotherapy
<p>Tumors exploit numerous immune checkpoints including those deployed by myeloid cells to curtail anti-tumor immunity. Here, we show that the C-type lectin receptor CLEC-1 expressed by myeloid cells senses dead cells killed by programmed necrosis. Moreover, we identified TRIM21 as an endogenous ligand over-expressed in various cancers. Interestingly, we observed that in mice CLEC-1 blockade combined with chemotherapy to prolong survival in tumor models. Loss of CLEC-1 reduced the accumulation of immunosuppressive myeloid cells in tumors and invigorated the activation state of dendritic cells (DCs), thereby increasing T cell responses. Mechanistically, we found that the absence of CLEC-1 increased the cross-presentation of dead-cell associated antigens by conventional type-1 DCs. Importantly, we identified anti-human CLEC-1 antagonist antibodies able to enhance anti-tumor immunity in CLEC-1 humanized mice. Altogether, our results demonstrate that CLEC-1 acts as an immune checkpoint in myeloid cells and support CLEC-1 as a novel target for cancer immunotherapy.</p>
Systems Analysis of Antigen Presenting Cells in Human Sepsis
ClinicalTrials.gov study NCT03788772. IPD Sharing: NO. Countries: 1. Publications: 1.
Proof-of-Concept Clinical Pharmacology Trial for HIV Antigen Presentation Therapeutic Biologic Mix
ClinicalTrials.gov study NCT07182838. IPD Sharing: NO. Countries: 1. Publications: 2.
Proof-of-Concept Clinical Pharmacology Trial for COVID-19 Antigen Presentation Therapeutic Biologic Mix
ClinicalTrials.gov study NCT03305341. IPD Sharing: NO. Countries: 1. Publications: 9.
Antigen Presentation and Lymphocyte Response in Parkinson's Disease
ClinicalTrials.gov study NCT02939534. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: TAPBPR bridges UDP-glucose:glycoprotein glucosyltransferase 1 onto MHC class I to provide quality control in the antigen presentation pathway
Recently we revealed that TAPBPR is a peptide exchange catalyst important for optimal peptide selection by MHC class I molecules. Here we asked if any other co-factors associate with TAPBPR which would explain its effect on peptide selection. We identify an interaction between TAPBPR and UDP-glucose:glycoprotein glucosyltransferase 1 (UGT1), a folding sensor in the calnexin/calreticulin quality control cycle known to regenerate the Glc1Man9GlcNAc2 moiety on glycoproteins. Our results suggest the formation of a multimeric complex, dependent on a conserved cysteine at position 94 in TAPBPR, in which TAPBPR promotes the association of UGT1 with peptide-receptive class I molecules. We reveal that the interaction between TAPBPR and UGT1 facilities the reglucosylation of the glycan on class I, promoting their recognition by calreticulin. Our results suggest that in addition to being a peptide-editor, TAPBPR improves peptide optimisation by promoting peptide-receptive MHC class I molecules to associate with the peptide-loading complex.
Source data of main figures of the effect of splicing inhibition on antigen presentation
<p>The success of cancer immunotherapy relies on the induction of an immunoprotective response targeting tumor antigens (TAs) presented on MHC-I molecules. We demonstrated that the splicing inhibitor isoginkgetin and its water-soluble and non-toxic derivative IP2 act at the production stage of the Pioneer Translation Products (PTPs). We showed that IP2 increases PTP-derived antigen presentation in cancer cells <i>in vitro </i>and impairs tumor growth <i>in vivo</i>. IP2 action is long-lasting and dependent on the CD8<sup>+</sup> T cell response against TAs. We observed that the antigen repertoire displayed on MHC-I molecules at the surface of MCA205 fibrosarcoma is modified upon treatment with IP2. In particular, IP2 enhances the presentation of an exon-derived epitope from the tumor suppressor nischarin. The combination of IP2 with a peptide vaccine targeting the nischarin-derived epitope showed a synergistic antitumor effect. These findings identify the spliceosome as a druggable target for the development of epitope-based immunotherapies.<b> </b></p>
Source data of main figures of the effect of splicing inhibition on antigen presentation
Open the record for dataset details and reuse information.
Data from: TAPBPR bridges UDP-glucose:glycoprotein glucosyltransferase 1 onto MHC class I to provide quality control in the antigen presentation pathway
Open the record for dataset details and reuse information.
Loss of SIRPα promotes podocytes presenting antigen to activate specific T cell immune responses in lupus nephritis via activating spleen tyrosine kinase
GEO Series GSE240916. Mus musculus. 2 samples. Type: Expression profiling by array.
Identification of human tumor-unique signaling networks between antigen-presenting cells and T cells using multi-omic single cell analysis
GEO Series GSE163633. Homo sapiens. 131 samples. Type: Expression profiling by high throughput sequencing.
Lung tumor MHCII immunity depends on in situ antigen presentation by fibroblasts. [CAF]
GEO Series GSE164653. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Chemotherapy promotes antigen presentation in monocytes of patients with high-grade serous ovarian carcinoma [RRBS]
GEO Series GSE264488. Homo sapiens. 14 samples. Type: Methylation profiling by high throughput sequencing.
Enhanced and selective translation expands the lysosome size and promotes antigen presentation during phagocyte activation
GEO Series GSE136470. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Mitochondrial respiration contributes to the interferon gamma response in antigen presenting cells
GEO Series GSE162463. Mus musculus. 17 samples. Type: Other.
FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity
GEO Series GSE173569. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Single-cell RNA-seq analysis of macaque tonsil antigen presenting cells
GEO Series GSE207261. Macaca fascicularis. 3 samples. Type: Expression profiling by high throughput sequencing.
A novel lineage of RORγt+ antigen presenting cells instructs microbiota-dependent regulatory T cell differentiation and tolerance during early life [multiome scRNA-seq]
GEO Series GSE205066. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.