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15
datasets available to search
ShareScore release 0.7.1
Dataset results
15 results for “antigen processing”
Tissue-specific factors differentially regulate the expression of antigen-processing enzymes during dendritic cell ontogeny
GEO Series GSE144421. Mus musculus. 21 samples. Type: Expression profiling by high throughput sequencing.
Data from: Selected HLA-B allotypes are resistant to inhibition or deficiency of the transporter associated with antigen processing (TAP)
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Cannabinoids act as H3k27ac Epigenetic Modifiers of Genes Regulating MHC-I Antigen Processing and Presentation that Induce Cytolytic T Lymphocyte Recognition of Metastatic Cancers
GEO Series GSE179897. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Gene expression analysis of molecules with known function in HLA class II antigen processing and presentation in hematopoietic and (cytokine pre-treated) non-hematopoietic cells.
GEO Series GSE38798. Homo sapiens. 28 samples. Type: Expression profiling by array.
IFNγ modulates the immunopeptidome of triple negative breast cancer cells by enhancing and diversifying antigen processing and presentation
GEO Series GSE163067. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Conventional and neo-antigenic peptides naturally processed and presented by beta cells are targeted by circulating naïve CD8+ T cells in type 1 diabetic and healthy donors
GEO Series GSE108413. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
Deciphering the role of cDC2s in Sjogren’s Syndrome: transcriptomic profile reveals altered antigen processing and uptake associated with IFN-signatures and autoimmunity
GEO Series GSE200020. Homo sapiens. 56 samples. Type: Expression profiling by high throughput sequencing.
Ezh2Y641F mutations co-operate with Stat3 to enhance MHC Class I antigen processing and alter the tumor immune response in melanoma
GEO Series GSE183819. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Differential antigen processing by dendritic cell subsets in vivo
GEO Series GSE6259. Mus musculus. 21 samples. Type: Expression profiling by array.
IRF4, a master transcription factor, regulates genes involved in BCR signaling, antigen processing and presentation, and GC development
GEO Series GSE64270. Homo sapiens. 5 samples. Type: Genome binding/occupancy profiling by genome tiling array; Expression profiling by array.
ILC2s directly activate anti-tumor cytotoxic CD8+ T lymphocytes by internalizing, processing, and presenting exogenous antigens
GEO Series GSE241945. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
IRF4, a master transcription factor, regulates genes involved in BCR signaling, antigen processing and presentation, and GC development [ChIP-chip]
GEO Series GSE64268. Homo sapiens. 3 samples. Type: Genome binding/occupancy profiling by genome tiling array.
IRF4, a master transcription factor, regulates genes involved in BCR signaling, antigen processing and presentation, and GC development [expression array]
GEO Series GSE64269. Homo sapiens. 2 samples. Type: Expression profiling by array.
Hippo signaling-controlled MHC-I antigen processing and presentation pathway potentiates antitumor immunity
GEO Series GSE253053. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Overexpression of miR-155-5p can upregulate antigen processing and presentation pathway via targeting tapasin
<p><strong>Background </strong>Dysregulation of major histocompatibility complex (MHC) class I antigen processing and presentation machinery (APM) components in the tumor as one main molecular mechanism of immune escape leading to deactivation of T cell immune surveillance could be due to post-transcriptional regulation via immune-modulatory microRNAs (miRNA). It is now well established from a variety of studies that several miRNAs could effectively modulate the expression of some MHC class I APM components in tumors. Tapasin is an important APM molecule involved in the association of MHC class I with transporter associated with antigen processing (TAP) and peptide loading. Since so far no detailed investigation of the posttranscriptional regulation of tapasin exists, the aim of this study is to identify and functionally characterize miRNAs targeting tapasin in melanoma.</p> <p><strong>Methods </strong>Using miRNA trapping by RNA <em>in vitro</em> affinity purification (miTRAP) and <em>in silico </em>as well as small RNA sequencing, miRNAs will be identified, which bind to the 3'untranslated region (3' UTR) of tapasin. Dual luciferase assays will be performed to determine binding of the miRNA. <em>In silico</em> analysis was performed to predict the effect of miRNAs on the survival of melanoma patients in correlation to tapasin. RT-qPCR, Western blot, flow cytometry and other functional assays were performed after transfecting miRNA mimics in three melanoma cell lines.</p> <p><strong>Results </strong>Using the combination strategy of miTRAP and RNA seq we identified miR-155-5p to bind to the 3’UTR of tapasin, which was further confirmed by <em>in silico analysis</em> and dual luciferase reporter assay. Transfection of miR-155-5p mimics demonstrated that miR-155-5p upregulate tapasin protein level, which was accompanied by an upregulation of the MHC class I (HLA-ABC) surface expression. Simultaneously, in several different types of cancer, including melanoma, the expression of miR-155-5p is significantly positively correlated with the patient's survival and HLA-A protein.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.