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140 results for “articular cartilage”
Quantitative susceptibility mapping of articular cartilage: ex vivo findings at multiple orientations and following different degradation treatments
<p>This dataset contains all the raw source data and MATLAB analysis functions that comprise the study:</p> <p><br> Quantitative susceptibility mapping of articular cartilage: Ex vivo findings at multiple orientations and following different degradation treatments</p> <p>Magnetic Resonance in Medicine | DOI: 10.1002/mrm.27216</p> <p>Nykänen Olli(1*), Rieppo Lassi(2,3), Töyräs Juha(1,4), Kolehmainen Ville(1), Saarakkala Simo(2,3,5), Shmueli Karin(6) and Nissi Mikko Johannes(1)</p> <p>(1) Department of Applied Physics, University of Eastern Finland, POB 1627, FI-70211 Kuopio, Finland<br> (2) Research Unit of Medical Imaging, Physics and Technology, University of Oulu, POB 5000, FI-90014 Oulu, Finland<br> (3) Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland<br> (4) Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland<br> (5) Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland<br> (6) Department of Medical Physics & Biomedical Engineering, University College London(UCL), London, United Kingdom</p> <p><br> *Corresponding author:<br> Olli Nykänen<br> Department of Applied Physics,<br> University of Eastern Finland<br> POB 1627<br> FI-70211, Kuopio, Finland<br> olli.nykanen@uef.fi<br> +358-50-5556357</p> <p><br> Keywords: cartilage, collagen matrix, quantitative susceptibility mapping, MRI, osteoarthritis</p> <p><br> Included folders and files are:<br> - article_figures: all figures published in the manuscript<br> - data: all MRI, histological, and PLM data used in this article<br> - matlab_functions: matlab functions used in data analysis with subfolders:<br> - aedes_plugins: plugins for aedes (http://aedes.uef.fi) for calculation of QS- and T2* maps<br> - fitting_functions: functions for fitting relaxation times or TKD-method for QSM, used by the functions in above folder<br> - miscellaneous_functions: small helper functions for a number of small tasks utilized by the other scripts and functions<br> - ReadMe.txt: this file</p> <p><br> Notes for setting up Aedes correctly for this dataset:<br> Run Aedes -> Tools -> Edit VNMR Defaults:<br> - Return: FT + K-space<br> - DC: off<br> - Zeropadding: off<br> - Sorting & fastread: on<br> - Precision: single<br> - Read_fcn: readvnmr<br> - Orient: no</p> <p>See more info in separate readme files included in each folder.</p> <p><br> (Olli Nykänen, Apr 17, 2018)</p>
Research data supporting "Raman spectroscopy reveals new insights into the zonal organization of native and tissue-engineered articular cartilage"
<p>This file contains the raw research data supporting the publication above.</p>
Dynamic deformation calculation of articular cartilage and cells using resonance-driven laser scanning microscopy - Deformable Registration Validation Dataset
<p>This dataset includes the supporting input files, scripts, and output files for validation tests of lsmgridtrack v0.3 applied to resonance scanned images. </p>
An in vivo stable isotope labeling method to investigate individual matrix protein synthesis, ribosomal biogenesis, and chondrocyte proliferation in murine articular cartilage
<p>These experiments have used a stable-isotope method using <em>in vivo</em> deuterium oxide labeling and mass spectrometry to measure protein concentration, protein half-life, cell proliferation, and ribosomal biogenesis in a single sample of murine articular cartilage. We hypothesized that a 60-day labeling period would capture age-related declines in cartilage matrix protein content, protein synthesis rates, and chondrocyte proliferation. Knee cartilage was isolated from 25- and 90-week-old female C57BL/6J mice treated with deuterium oxide for 15, 30, 45 and 60 days. We measured protein abundance and half-lives using high resolution accurate mass spectrometry (HRAM) and d2ome data processing software. </p>
Data for: NFATc1 marks articular cartilage progenitors and negatively determines articular chondrocyte differentiation
<p>The origin and differentiation mechanism of articular chondrocytes remain poorly understood. Broadly, the difference in developmental mechanisms of articular and growth-plate cartilage is still less elucidated. Here, we identified that the nuclear factor of activated T-cells cytoplasmic 1 (NFATc1) is a crucial regulator of articular, but not growth-plate, chondrocyte differentiation during development. At the early stage of mouse knee development (embryonic day 13.5), NFATc1-expressing cells were mainly located in the flanking region of the joint interzone. With development, NFATc1-expressing cells generated almost all articular chondrocytes, but not chondrocytes in limb growth-plate primordium. NFATc1-expressing cells displayed prominent capacities for colony formation and multipotent differentiation. Transcriptome analyses revealed a set of characteristic genes in NFATc1-enriched articular cartilage progenitors. Strikingly, the expression of NFATc1 was diminished with articular chondrocyte differentiation and suppressing NFATc1 expression in articular cartilage progenitors was sufficient to induce spontaneous chondrogenesis while overexpressing NFATc1 suppresses chondrogenesis. Mechanistically, NFATc1 negatively regulated the transcriptional activity of the <em>Col2a1</em> gene. Thus, our results reveal that NFATc1 characterizes articular, but not growth-plate, cartilage progenitors during development and negatively determines articular chondrocyte differentiation at least partly through regulating COL2A1 gene transcription.</p>
Superiority of MACI® Versus Microfracture Treatment in Patients With Symptomatic Articular Cartilage Defects in the Knee
ClinicalTrials.gov study NCT00719576. IPD Sharing: NO. Countries: 7. Publications: 1.
Trial Comparing BST-CarGel and Microfracture in Repair of Articular Cartilage Lesions in the Knee
ClinicalTrials.gov study NCT00314236. IPD Sharing: Not stated. Countries: 3. Publications: 4.
Data for: NFATc1 marks articular cartilage progenitors and negatively determines articular chondrocyte differentiation
Open the record for dataset details and reuse information.
Evaluation of articular cartilage with quantitative MRI in an equine model of post-traumatic osteoarthritis
<p>This dataset contains raw qMRI data and the corresponding calculated relaxation time maps, reference data and an example MATLAB script demonstrating how to access the data, comprising study:</p> <p><strong>Evaluation of articular cartilage with quantitative MRI in an equine model of post-traumatic osteoarthritis </strong></p> <p>Journal of Orthopaedic Research | DOI: https://doi.org/10.1002/jor.24780</p> <p>Kajabi Abdul Wahed*(1,2), Casula Victor(1,2), Sarin Jaakko K.(3,4), Ketola Juuso H.(1), Nykänen Olli(3), te Moller Nikae C.R.(5), Mancini Irina A.D.(5), Visser Jetze(6), Brommer Harold(5), van Weeren P. René(5), Malda Jos(5,6), Töyräs Juha(3,4,7), Nieminen Miika T.(1,2,8), Nissi Mikko J.*(1,3)</p> <ol> <li>Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland</li> <li>Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland </li> <li>Department of Applied Physics, University of Eastern Finland, Kuopio, Finland</li> <li>Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland</li> <li>Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, The Netherlands</li> <li>Department of Orthopaedics, University Medical Center Utrecht, The Netherlands </li> <li>School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Australia</li> <li>Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland </li> </ol> <p> </p> <p>*Corresponding authors:<br> Mikko J. Nissi<br> Department of Applied Physics,<br> University of Eastern Finland<br> POB 1627,<br> FI-70211, Kuopio, Finland<br> mikko.nissi@uef.fi<br> +358-50-5955517</p> <p>Abdul Wahed Kajabi<br> Research Unit of Medical Imaging, Physics and Technology,<br> University of Oulu<br> POB 50,<br> FI-90029, Oulu, Finland<br> abdul.kajabi@oulu.fi<br> +358-50-3037425</p> <p>Keywords: cartilage, post-traumatic, osteoarthritis, quantitative MRI, relaxation times</p> <p>The file "Pony_AllData.mat" contains all the data of the study. The main struct variable in the file ("all_data") contains several fields storing all the data per sample. In the following, brief descriptions for the main subfields are given:</p> <ul> <li>name: contains generic name of the sample</li> <li>qMRI_Data: contains qMRI raw data, the corresponding relaxation time maps and normalized cartilage full-thickness ROI profiles</li> <li>calcROI_Data: contains ROIs used to calculate the relaxation time maps</li> <li>analysisROI_Data: ROIs used for the analysis</li> <li>DD_prof and interpDD_prof: Original and interpolated profiles for proteoglycan content (Optical Density)</li> <li>PLM_prof and interpPLM_prof: Original and interpolated profiles for collagen fiber orientation (Polarized Light Microscopy)</li> <li>E_eq and E_dyn: Equilibrium and dynamic moduli of articular cartilage.</li> </ul> <p>The example script, "Analysis_script.m" contains a short demonstration on how the data in the struct can be accessed. The script assumes that Aedes (http://aedes.uef.fi) analysis software is available for matlab.</p> <p>(Abdul Wahed Kajabi, 17 Jun 2020)</p>
Dynamic deformation calculation of articular cartilage and cells using resonance-driven laser scanning microscopy - Osmotic Challenge and Validation Testing Dataset
<p>This archive contains 3-D image stacks obtained over time of articular cartilage undergoing osmotic swelling. These were acquired with a resonance scanning protocol, which allows for fast scanning but with decreased image quality. The Python package, resonant_lsm, was developed to segment and analyze the deformation of cells in such images. The archive also contains validation testing data of this software. Included README files document the archive contents and how to reproduce the analyses. </p>
Tissue Engineered Nasal Cartilage for Regeneration of Articular Cartilage
ClinicalTrials.gov study NCT01605201. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of Intra-articular Stromal Vascular Fraction Injection on Clinical Symptoms and Cartilage Health in Osteoarthritic Knees
ClinicalTrials.gov study NCT06562101. IPD Sharing: Not stated. Countries: 1. Publications: 15.
Mesenchymal Stem Cells in a Clinical Trial to Heal Articular Cartilage Defects
ClinicalTrials.gov study NCT00885729. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Effect of Autologous Peripheral Blood Stem Cell Treatment on Articular Cartilage Regeneration
ClinicalTrials.gov study NCT01076673. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Microfracture Versus Adipose Derived Stem Cells for the Treatment of Articular Cartilage Defects
ClinicalTrials.gov study NCT02090140. IPD Sharing: NO. Countries: 1. Publications: 10.
Autologous Chondrocyte Transplantation For Articular Cartilage Regeneration
ClinicalTrials.gov study NCT01503970. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Study to Compare Efficacy and Safety of Cartistem and Microfracture in Patients With Knee Articular Cartilage Injury
ClinicalTrials.gov study NCT01041001. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Articular Cartilage Resurfacing With Mesenchymal Stem Cells In Osteoarthritis Of Knee Joint
ClinicalTrials.gov study NCT01207661. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Follow-Up Study of CARTISTEM® Versus Microfracture for the Treatment of Knee Articular Cartilage Injury or Defect
ClinicalTrials.gov study NCT01626677. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Adult Stem Cell Therapy for Repairing Articular Cartilage in Gonarthrosis
ClinicalTrials.gov study NCT01227694. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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International Brain Laboratory public data
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OpenNeuro
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