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3,389 results for “asthma”
Inter-Chemical Correlation results for the study: HHEARx2017-1982 (Domestic Indoor PM and Childhood Asthma Morbidity (DISCOVER Study))
Title: Domestic Indoor PM and Childhood Asthma Morbidity (DISCOVER Study) <br>Species: Homo sapiens <br>Number of samples: 732 <br>Number of named analytes: 26 <br>Datasource url: https://hheardatacenter.mssm.edu/PublicFile/ViewPublicFile?projectid=35 <br>
Inter-Chemical Correlation results for the study: HHEARx2017-1863 (Investigating Overweight/Obesity and Poor Diet as Susceptibility Factors for Secondhand Smoke in Childhood Asthma)
Title: Investigating Overweight/Obesity and Poor Diet as Susceptibility Factors for Secondhand Smoke in Childhood Asthma <br>Species: Homo sapiens <br>Number of samples: 960 <br>Number of named analytes: 37 <br>Datasource url: https://hheardatacenter.mssm.edu/PublicFile/ViewPublicFile?projectid=29 <br>
Inter-Chemical Correlation results for the study: HHEARx2016-1450 (Denver Asthma Panel Study-CHEAR Ancillary Study)
Title: Denver Asthma Panel Study-CHEAR Ancillary Study <br>Species: Homo sapiens <br>Number of samples: 911 <br>Number of named analytes: 33 <br>Datasource url: https://hheardatacenter.mssm.edu/PublicFile/ViewPublicFile?projectid=12 <br>
Inter-Chemical Correlation results for the study: HHEARx2016-1407 (Pediatric Inner-City Environmental Exposures at School and Home and Asthma Study)
Title: Pediatric Inner-City Environmental Exposures at School and Home and Asthma Study <br>Species: Homo sapiens <br>Number of samples: 157 <br>Number of named analytes: 28 <br>Datasource url: https://hheardatacenter.mssm.edu/PublicFile/ViewPublicFile?projectid=2 <br>
Data from: Offspring behavioral outcomes following maternal allergic asthma in the IL-4-deficient mouse
<p>Background: Maternal allergies and asthma during pregnancy have been associated with increased risk of ASD and ADHD to the child. Previous rodent studies have demonstrated that inducing a T helper-2 (Th2)-mediated allergic response during pregnancy leads to an offspring behavioral phenotype characterized by decreased social interaction and increased stereotypies. Interleukin-4 is a key signal in the Th2 immune cascade, but its role in fetal brain development and subsequent impacts of maternal allergic asthma (MAA) on offspring behavioral deficits have yet to be determined.</p> <p>Objective: In this study, we investigated whether the absence of IL-4 signaling would mitigate MAA-induced behavioral changes.</p> <p>Methods: C57BL/6J and Interleukin-4 knockout (IL-4 KO) mice were sensitized to ovalbumin and exposed to repeated allergic asthma aerosol inductions throughout pregnancy. Offspring were assessed on Juvenile Reciprocal Social Interaction, Elevated Plus Maze, Open Field Exploration, Novel Object Recognition, Forced Swim, Marble-burying, and Grooming tasks.</p> <p>Results: MAA during pregnancy resulted in decreased social interactions in male C57 offspring and impaired memory performance in both male and female C57 mice. These deficits were not observed in IL-4 KO mice exposed to MAA. However, we observed genotype effects in IL-4 KO mice including altered motor performance and anxiety-associated responses.</p> <p>Conclusion: MAA-induced social and cognitive behavioral alterations are IL-4 dependent. IL-4KO offspring display genotype-specific differences suggesting IL-4 signaling is important for typical developmental processes.</p>
The Upper-Airway Microbiome as a Biomarker of Asthma Exacerbations despite Inhaled Corticosteroid Treatment
<p>The response to inhaled corticosteroids (ICS) in asthma is affected by the interplay of several factors. Among these, the role of the upper-airway microbiome has been scarcely investigated. We aimed to evaluate the association between the salivary, pharyngeal, and nasal microbiome with asthma exacerbations despite ICS use. Samples from 250 asthma patients from the Genomics and Metagenomics of Asthma Severity (GEMAS) study treated with ICS were analyzed. Controls/cases were defined by the absence/presence of asthma exacerbations in the past six months despite being treated with ICS. The bacterial microbiota was profiled by sequencing the V3-V4 region of the 16S rRNA gene. Differences between groups were assessed by PERMANOVA and regression models adjusted for potential confounders. A false discovery rate (FDR) of 5% was used to correct for multiple comparisons. Classification models of asthma exacerbations despite ICS treatment were built with machine learning approaches based on clinical, genetic, and microbiome data. In nasal and saliva samples, cases had lower bacterial diversity (Richness, Shannon, and Faith indexes) than controls (0.007≤p≤0.037). Asthma exacerbations accounted for 8-9% of the interindividual variation of the salivary and nasal microbiomes (0.003≤p≤0.046). Three, four, and eleven bacterial genera from the salivary, pharyngeal, and nasal microbiomes were differentially abundant between groups (4.09x10<sup>-12</sup>≤FDR≤0.047). Integrating clinical, genetic, and microbiome data showed good discrimination for the development of asthma exacerbations despite ICS use (AUC<sub>training</sub>:0.82 and AUC<sub>validation</sub>:0.77). The diversity and composition of the upper-airway microbiome are associated with asthma exacerbations despite ICS treatment. The salivary microbiome has a potential application as a biomarker of asthma exacerbations despite ICS use.</p> <p>The summary results of the association between bacterial genera and asthma exacerbations despite ICS use are published in this repository. Analyses were conducted using the DESeq2 package adjusting for potential confounders (see more details in the manuscript). The submitted summary tables contains the following columns:</p> <ul> <li>Kingdom: Taxonomic classification at Kingdom level</li> <li>Phylum: Taxonomic classification at Phylum level</li> <li>Class: Taxonomic classification at Class level</li> <li>Order: Taxonomic classification at Order level</li> <li>Family: Taxonomic classification at Family level</li> <li>Genus: Taxonomic classification at Genus level</li> <li>log2FC: log<sub>2</sub>(fold-change). Positive values indicate higher abundance in cases and negative values in controls</li> <li>SE: standard error of log<sub>2</sub>(fold-change)</li> <li>P.Value: p-value of the regression model</li> <li>FDR: adjusted p-value by false discovery rate (Benjamin-Hochberg method)</li> </ul>
Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies
<p>GWAS summary results from the paper</p> <p>The Lancet Respiratory Medicine: http://dx.doi.org/10.1016/S2213-2600(19)30055-4</p> <p>Preprint: https://doi.org/10.1101/427427</p>
Asthma control conundrum in clinical practice – Data from a two-stage Delphi survey and literature review
<p>Definitions and measures of asthma control used in clinical trials and practice often vary, as highlighted in the manuscript, “Is asthma control more than just an absence of symptoms? An expert consensus statement”. Furthermore, the authors discussed differences between patients and healthcare professionals (HCPs) in terms of understanding and managing asthma. Given these disparities, there is a need for consensus regarding what constitutes well-controlled asthma and, especially, how best it can be measured and recorded. This dataset describes and provides more detail on the methodology from a two-stage Delphi survey and a structured literature review, which were designed to reach a consensus definition of asthma control and alleviate misalignments between patients and HCPs.</p>
Human Genetics Influences Microbiome Composition Involved in Asthma Exacerbations despite Inhaled Corticosteroid Treatment
<p>Additional Supplement Data of the manuscript Perez-Garcia J, Espuela-Ortiz A, Hernández-Pérez JM, et al. Human Genetics Influences Microbiome Composition Involved in Asthma Exacerbations despite Inhaled Corticosteroid Treatment (in press). <em>J Allergy Clin Immunol</em>. 2023;S0091-6749(23)00748-0. doi:10.1016/j.jaci.2023.05.021.</p> <p>This Supplement Data contains the following items:</p> <table> <tbody> <tr> <td>Additional Table 1</td> <td>List of independent mbQTLs associated with p<1x10<sup>-5</sup> in the mbGWAS from saliva samples in Europeans (discovery).</td> </tr> <tr> <td>Additional Table 2</td> <td>List of independent mbQTLs associated with p<1x10<sup>-5</sup> in the mbGWAS from pharyngeal samples in Europeans (discovery).</td> </tr> <tr> <td>Additional Table 3</td> <td>List of independent mbQTLs associated with p<1x10<sup>-5</sup> in the mbGWAS from nasal samples in Europeans (discovery).</td> </tr> <tr> <td>Additional Table 4</td> <td>Summary results of enrichment analyses using the Enrichr platform.</td> </tr> <tr> <td>Additional Table 5</td> <td>Summary results of stratified enrichment analyses by biological sample type.</td> </tr> <tr> <td>Additional Table 6</td> <td>List of independent mbQTLs associated with p<1x10<sup>-5</sup> in the mbGWAS from saliva samples in African Americans (replication phase).</td> </tr> <tr> <td>Additional Table 7</td> <td>List of independent mbQTLs associated with p<1x10<sup>-5</sup> in the mbGWAS from saliva samples in Latinos (replication phase).</td> </tr> <tr> <td>Additional Table 8</td> <td>Summary results of replication enrichment analyses in saliva samples.</td> </tr> <tr> <td>Additional Table 9</td> <td>Summary statistics of the mbQTL analysis of <em>Streptococcus</em> in nasal samples.</td> </tr> <tr> <td>Additional Table 10</td> <td>Summary statistics of the mbQTL analysis of <em>Campylobacter</em> in pharyngeal samples.</td> </tr> <tr> <td>Additional Table 11</td> <td>Summary statistics of the mbQTL analysis of <em>Tannerella</em> in pharyngeal samples.</td> </tr> <tr> <td>Additional Table 12</td> <td>Summary table of the different genetic models tested for each mbQTL pair.</td> </tr> </tbody> </table>
TRIple in Asthma hiGh strenGth vErsus Ics/Laba hs and tiotRopium (TRIGGER)
ClinicalTrials.gov study NCT02676089. IPD Sharing: YES. Countries: 17. Publications: 6.
Study of Efficacy and Safety of QAW039 in Patients With Severe Asthma Inadequately Controlled With Standard of Care Asthma Treatment.
ClinicalTrials.gov study NCT02563067. IPD Sharing: UNDECIDED. Countries: 19. Publications: 1.
AQI and Childhood Asthma: an Intervention
ClinicalTrials.gov study NCT04454125. IPD Sharing: NO. Countries: 1. Publications: 2.
Study of QMF149 (150/80 µg) Compared With MF Twisthaler® (200 µg) in Patients With Asthma
ClinicalTrials.gov study NCT02892344. IPD Sharing: UNDECIDED. Countries: 22. Publications: 1.
A Phase 4, Randomized, Double-blind, Placebo-controlled, Multicenter, Parallel-group Study of the Effect of Dupilumab on Sleep Disturbance in Patients With Uncontrolled Persistent Asthma
ClinicalTrials.gov study NCT04502862. IPD Sharing: YES. Countries: 11. Publications: 0.
Examining Changes in Nasal IL-1 During Acute Asthma Exacerbation in Adolescents
ClinicalTrials.gov study NCT04748055. IPD Sharing: YES. Countries: 1. Publications: 1.
Assess Bronchodilator Effect and Safety of Two Doses of QVM149 Compared to a Fixed Dose Combination of Salmeterol/Fluticasone in Patients With Asthma.
ClinicalTrials.gov study NCT03063086. IPD Sharing: UNDECIDED. Countries: 6. Publications: 1.
Study of Safety of QAW039 in Patients With Asthma Inadequately Controlled on Standard-of-care Asthma Treatment
ClinicalTrials.gov study NCT03052517. IPD Sharing: YES. Countries: 42. Publications: 1.
The Effect of Dupilumab on Lung Inflammation and Related Changes in Airway Volumes Detectable by Functional Respiratory Imaging in Patients With Moderate-severe Asthma
ClinicalTrials.gov study NCT04400318. IPD Sharing: YES. Countries: 13. Publications: 2.
Evaluation of SAR440340 and as Combination Therapy With Dupilumab in Moderate-to-Severe Asthma Participants
ClinicalTrials.gov study NCT03387852. IPD Sharing: YES. Countries: 8. Publications: 2.
Efficacy and Safety of Indacaterol Acetate Delivered Via the Concept1 Inhalation Device in Children Greater or Equal to 6 and Less Than 12 Years of Age With Asthma
ClinicalTrials.gov study NCT02892019. IPD Sharing: UNDECIDED. Countries: 11. Publications: 1.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.