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63 results for “birth cohort”
Volatile organic compound analysis, a new tool in the quest for preterm birth prediction – an observational cohort study
<p>Vaginal swabs were taken in pregnancy in high risk asymptomatic women attending a preterm prevention clinic. Women in the study attended the clinical due to a history of preterm birth or midtrimester pregnancy loss, or due to a history of cervical surgery. Individualised management plans were made depending upon individual patient risk factors. During their attendance to the clinic vaginal swabs were taken for VOC analysis. Swabs were taken between 15 and 28 weeks gestation. Women consented to vaginal swabs at each of their visits to the clinic. The dataset contains GC-IMS VOC data from a G.A.S. GC-IMS and includes a Spreadsheet of demographics.</p>
Mothers of twins had higher old-age survival than mothers of singletons in Estonian 19th-century birth cohorts
<p><strong><span>Study question:</span></strong><span> Do the mothers of twins and singletons differ regarding post-partum and old-age mortality?</span></p> <p><span> </span><strong><span>Summary answer:</span></strong><span> M</span><span>others of twins had twice as high post-partum mortality as mothers of singletons; survival of twinners was higher than survival of the mothers of singletons after the 67<sup>th </sup>lifespan percentile.</span></p> <p><strong><span>What is known already:</span></strong><span> Twinning is typically associated with higher post-partum maternal mortality. The evidence about whether twinning incurs long-term survival costs of reproduction or is a trait pertinent to long-lived women is scarce and contradictory.</span></p> <p><strong><span>Study design, size, duration:</span></strong><span> The study is based on the data of the Estonian Family Register (operating from 1926-43) and involves 5 565 mothers of twins and 119 613 mothers of singletons born between 1850-99. The subset for comparing maternal lifespans included 1 703 – 1 884 mothers of twins and </span><span>19 747 </span><span>– 36 690 mothers of singletons.</span></p> <p><strong><span>Participants/materials, setting, methods:</span></strong><span> Post-partum maternal mortality was analysed in the whole sample (including mothers of a single child) by logistic regression. Most of the analyses were performed in samples where each mother of twins was matched against mothers of singletons based on parity, urban versus rural origin, whether their lifespan was known, date of birth and age at first birth. Quantile regression was used to analyse age-dependent variations in maternal mortality rates. Lifespans were compared in linear mixed models. All models were adjusted for relevant biodemographic covariates.</span></p> <p><strong><span>Main results and the role of chance:</span></strong><span> The twinning rate in the whole sample was 4.4%. During the year after giving birth, maternal mortality for multiple gestations was 0.75% (17/2 273) and 0.37% (</span><span>449</span><span>/</span><span>122 750)</span><span> for single gestations (OR = 2.05, 95% CI = 1.21 – 3.23). The association between twinning and post-natal maternal mortality remained significant in a model controlling for parity and age of first and last birth. The life spans of the mothers of twins and singletons did not differ in matched samples. Past the 67<sup>th</sup> lifespan percentile, the odds of survival were significantly higher for mothers of twins than mothers of singletons, as indicated by non-overlapping 95% confidence intervals.</span></p> <p><strong><span>Limitations, reasons for caution: </span></strong><span>Relatively low number of individuals (22 802) with known age at death due to discontinuation of the register after 1943.</span></p>
Simulated Real Measure Data In a Birth Cohort
<pre><span>These data mimic what we can find when observing fetal growth using ultrasounds. </span></pre> <pre><span>They are not observed at the same moments in time for each mother-fetus binomial or in the same number of times. </span></pre> <pre><span>They are data simulated through a transformation of the Wiener process to the non-homogeneous lognormal diffusion process called Gompertz-lognormal.</span></pre>
Stability and change in male fertility patterns by cognitive ability across 32 birth cohorts
<p>The relationship between cognitive ability (CA) and childbearing remains unsettled. Using Norwegian administrative registers with population coverage, we study how male lifetime fertility patterns differ across cognitive score groups, and how these changed across the 1950–1981 birth cohorts, covering a period characterized by rapid social and economic change. The analyses reveal systematic differences in fertility and fertility timing across CA groups, with high-scoring males having delayed but ultimately higher fertility than lower-scoring males. This pattern remains stable over time despite strong trends towards delayed and reduced fertility. The overall positive relationship between CA and fertility is primarily driven by high rates of childlessness in the lowest-scoring group, with low-scoring males showing higher rates of parity progression conditional on having children.</p>
Stability and change in male fertility patterns by cognitive ability across 32 birth cohorts
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Implementation and adherence of routine pertussis vaccination (DTP) in a low-resource urban birth cohort
<p><strong>Introduction</strong>: Reliable information on rates of up-to-date coverage and timely administration of routine childhood immunizations is critical for guiding public health efforts worldwide, yet prospective observation of vaccination programs within individual communities is rare. Here we provide a longitudinal analysis of the directly-observed administration of a 3-dose primary vaccination series to infants in a low-resource community in Lusaka, Zambia.</p> <p><strong>Methods</strong>: Throughout 2015, we recruited a longitudinal birth cohort of mother/infant pairs (initial enrollment, 1,981 pairs; attending, 1,497 pairs) from the peri-urban informal settlement of Chawama compound, located in Lusaka, Zambia. We prospectively monitored the administration of scheduled Diphtheria-Tetanus-Pertussis (DTP) vaccinations across the first 14-18 weeks of life. We analyzed study attendance and vaccine coverage, both overall and stratified by age group. We employed Kaplan-Meier analyses to estimate delays in age-appropriate administration of vaccine doses. We also assessed schedule timing violations, including early and compressed dose administration.</p> <p><strong>Results</strong>: At study completion, first dose (DTP1) rates were high (92.9% of attending), whereas third dose completion (DTP3) rates were far lower (61.9%). Missed vaccinations and study dropout both contributed to the low DTP3 completion rates. DTP1 was administered very late (at or after 10 weeks) to 61 infants (4.1%). DPT1 was administered too early to 64 infants (4.3%), and 77 (5.1%) received consecutive doses below the minimum recommended spacing of 28 days.</p> <p><strong>Conclusions</strong>: We observe substantial individual variation in the timing of early childhood DTP doses, though following this birth cohort proved challenging. Our results indicate that timely administration of both DTP1 and DPT3 remains a challenge in this community. These directly-observed, individual-based results provide an important counterpoint to more course-grained, survey-based national and province estimates of up-to-date vaccine coverage. This study also highlights the challenges of vaccine hesitancy and sub-optimal utilization of (no-cost) healthcare services in a low-resource urban setting.</p>
A Longitudinal, Cohort Study Investigating the Impact of General Anaesthetic Caesarean Birth, With or Without ICU Admission, on Maternal Mental Health and Mother/Infant Bonding
ClinicalTrials.gov study NCT07115823. IPD Sharing: NO. Countries: 1. Publications: 30.
Implementation and adherence of routine pertussis vaccination (DTP) in a low-resource urban birth cohort
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Data from: Vaginal host immune-microbiome interactions in a cohort of primarily African-American women who ultimately underwent spontaneous preterm birth or delivered at term
<p><strong>Background</strong>: Recent studies suggest that alterations in the vaginal microbiome allow for the assessment of the risk for spontaneous preterm birth (PTB), the leading cause of neonatal morbidity and mortality worldwide. However, the associations between the local immune response and the vaginal microbiome are still poorly understood. Herein, we characterize the vaginal host immune-microbiome interactions in women who ultimately underwent PTB and in those who delivered at term.</p> <p><strong>Methods</strong>: Vaginal fluid samples from 52 pregnant women (of whom 18 underwent PTB and 34 delivered at term) were collected from 10-32 weeks in a case-control study. Concentrations of 33 immune mediators were determined using sensitive and specific immunoassays. The previously published 16S rRNA gene sequence and bacterial phylotype data of these subjects were utilized in this study. Linear mixed effects models were utilized to test associations between vaginal immune mediator concentrations and bacterial phylotype relative abundances.</p> <p><strong>Results</strong>: 1) Specific immune mediators (β-defensins 2 and 3, IL-1β, CXCL10, CCL2, CCL3, SLPI, and VEGF) correlated with 18 different vaginal bacterial phylotypes in the overall study population; 2) vaginal concentrations of CXCL10, CCL2, CCL3, SLP1 and VEGF negatively correlated with non-Lactobacillus members of the vaginal microbiome; 3) vaginal concentrations of CXCL10 were negatively correlated with 15 bacterial phylotypes, most of which are typical members of Community State Type IV of the vaginal microbiome, such as Gardnerella vaginalis, Megasphaera sp. type 1, and Atopobium vaginae; 4) Gemella spp. were negatively correlated with vaginal concentrations of VEGF, CCL2, CCL3, SLPI, and CXCL10; 5) when comparing PTB cases to term controls, five soluble immune mediators (CCL26, CCL22 and CCL2, CXCL10 and IL-16), and especially CCL26, were negatively correlated with five typical members of Community State Type IV: Sneathia sanguinegens, Parvimonas micra, Veillonellaceae, BVAB2, and Gemella spp; and 6) Sneathia sanguinegens had stronger negative associations with all five soluble immune mediators (CCL26, CCL22 and CCL2, CXCL10 and IL-16) in PTB cases than in term controls.</p> <p><strong>Conclusions</strong>: The assessment of vaginal host immune-microbiome interactions revealed that specific soluble immune mediators, mainly CXCL10, negatively correlated with typical members of Community State Type IV of the vaginal microbiome. In addition, this assessment particularly showed that Sneathia sanguinegens had stronger negative associations with different immune mediators, including CXCL10 and CCL26, in women who ultimately had a PTB compared to those who delivered at term. These findings provide insight into the vaginal host immune-microbiome interactions in normal and complicated pregnancies.</p>
Differential cross-reactivity to the influenza B virus haemagglutinin underpins lineage-specific susceptibility between birth cohorts
<p>Data and code relataing to "Differential cross-reactivity to the influenza B virus haemagglutinin underpins lineage-specific susceptibility between birth cohorts" Edler et al study https://www.biorxiv.org/content/10.1101/2023.08.25.554879v1<br><br></p> <p> </p>
The Jiaxing Birth Cohort in China
ClinicalTrials.gov study NCT03217656. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Boston Birth Cohort Study
ClinicalTrials.gov study NCT03228875. IPD Sharing: NO. Countries: 1. Publications: 8.
Bern Birth Cohort / Trajectory of Microbiota Maturation in Healthy Bern Infants - a Network Approach
ClinicalTrials.gov study NCT04447742. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
The Next Generation Longitudinal Birth Cohort Diabetes Study
ClinicalTrials.gov study NCT04621396. IPD Sharing: NO. Countries: 1. Publications: 1.
TT-CMV Observational Birth Cohort Study
ClinicalTrials.gov study NCT00907686. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Birth-Cohort Evaluation to Advance Screening and Testing for Hepatitis C
ClinicalTrials.gov study NCT02123212. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Colposcopic Impression in a Birth Cohort Previously Eligible for HPV-vaccination
ClinicalTrials.gov study NCT04909814. IPD Sharing: YES. Countries: 1. Publications: 1.
Effect of Obstetric Anesthesia and Delivery Mode On Neurodevelopmental And Behavioural Outcomes In A Population-Based Birth Cohort
ClinicalTrials.gov study NCT05196750. IPD Sharing: NO. Countries: 1. Publications: 4.
Birth Cohort Study of China Medical University
ClinicalTrials.gov study NCT03561766. IPD Sharing: NO. Countries: 1. Publications: 1.
Birth Cohort in Coast Province, Kenya
ClinicalTrials.gov study NCT02448615. IPD Sharing: Not stated. Countries: 1. Publications: 5.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.