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318 results for “brd4”
Raw diffraction images of the first bromodomain of human BRD4 in complex with (+)-JD1
<p>Raw diffraction images of the first bromodomain of human BRD4 in complex with (+)-JD1, an Organometallic BET Bromodomain Inhibitor. The final structure is deposited in the Protein Data Bank under accession code <a href="http://www.rcsb.org/structure/6SE4">6SE4</a>.</p> <p>The structure is part of the following publication:</p> <p>Hassell-Hart, S., Runcie, A., Krojer, T., Doyle, J., Lineham, E., Ocasio, C.A., Neto, B.A.D., Fedorov, O., Marsh, G., Maple, H., et al. (2019). Synthesis and Biological Investigation of (+)-JD1, an Organometallic BET Bromodomain Inhibitor. Organometallics. doi: 10.1021/acs.organomet.9b00750.</p> <p> </p> <p>Additional information:</p> <p>dataset: BRD4A-JD1_i03<br> beamline: Diamond Light Source I03<br> visit: mx19301-7<br> date: 25-11-2018<br> Flux: 2.03e+11<br> Ω Start: 0.0°<br> Ω Osc: 0.15°<br> Ω Overlap: 0°<br> No. Images: 1200<br> Resolution: 1.50Å<br> Wavelength: 0.9762Å<br> Exposure: 0.030s<br> Transmission: 100.00%<br> Beamsize: 80x20μm</p> <p>datasets: BRD4A-JD1_i04<br> beamline: Diamond Light Source I04<br> visit: mx19301-9<br> date: 08-12-2018<br> Flux: 6.62e+11<br> Ω Start: 0.0°<br> Ω Osc: 0.50°<br> Ω Overlap: 0°<br> No. Images: 720<br> Resolution: 2.30Å<br> Wavelength: 1.7384Å<br> Exposure: 0.050s<br> Transmission: 100.00%<br> Beamsize: 32x20μm</p> <p>Additionally, a cif file containing refinement restraints and a png file for the ligand JD1 is included.</p>
BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III
<p>This is a high content drug screening dataset composed of images and single-cell analysis results from a 384-well plate </p> <p>The SPLICS reporter is composed of a split GFP1-10 barrel localized to the mitochondrial outer membrane, a P2A self-cleavage signal for equimolar expression, and the remaining beta11 fragment targeted to the ER membrane. Upon ERMCS formation within the 8-10 nm distance, the split-GFP reporter forms intact GFP. Doxycycline-inducible SPLICS reporter stable cell lines were generated via a three-plasmid PiggyBac transposase system. Cells were co-transfected with the plasmids using Lipofectamine 2000 transfection reagent, then the next day selected with 2 mg/ml of G418 (Geneticin) for 7 days. With the SPLICS integrated cells, mitochondrial TagRFP is expressed in them. For mitochondrial TagRFP labeling in cells, we utilized a lentiviral backbone and introduced a mitochondria matrix TagRFP (mitoTagRFP) to control for gene expression and monitor mitochondrial abundance. After mitoTagRFP integration, 100 ng/ml of doxycycline were used to induce SPLICS reporter expression, and GFP/TagRFP double positive cells were sorted on Bigfoot Spectral Cell Sorter (Invitrogen) to isolate GFP/TagRFP positive clones. Clones were cultured and screened for accurate localization of SPLICS reporter to mitochondria and ER via live cell imaging and for normal mitochondrial oxygen consumption rate. Probe induction did not have a deleterious effect on cell number or increasing green fluorescence for at least 72 hours of reporter induction. For ERMCS analysis with SPLICS, cells will be induced with 100 ng/ml of doxycycline for minimally 24 hr before treatment or analysis.</p>
Targeting BRD4 Ameliorates Experimental Emphysema Via Suppressing both M1 and M2 alveolar macrophage polarization-1[RNA-seq]
GEO Series GSE248962. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Dynamic chromatin targeting of BRD4 stimulates cardiac fibroblast activation [RNA-seq]
GEO Series GSE127229. Rattus norvegicus. 9 samples. Type: Expression profiling by high throughput sequencing.
MZ1, a BRD4 inhibitor, exerted its anti-cancer effects by targeting the super-enhancer-regulated gene SDC1 in Glioblastoma [RNA-Seq]
GEO Series GSE244878. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Inhibition of BRD4 Attenuates ER Stress-induced Renal Ischemic-Reperfusion Injury
GEO Series GSE217103. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
Effects of BRD4 inhibitor JQ1 on the expression profile in cervical cancer HeLa cells
GEO Series GSE235031. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Distinct roles of Brd2 and Brd4 in potentiating the transcriptional program for Th17 cell differentiation
GEO Series GSE63778. Mus musculus. 10 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Metabolically controlled histone H4K5 acylation/acetylation ratio drives BRD4 genomic distribution
GEO Series GSE164072. Homo sapiens. 83 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Toggling of BRD4 functions is triggered through its phosphorylation by JNK [RNA-seq]
GEO Series GSE252980. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Znf687 recruits Brd4-Smrt complex to regulate gfi1aa expression during neutrophil development
GEO Series GSE235609. Danio rerio. 4 samples. Type: Expression profiling by high throughput sequencing.
IDR-Targeting Compounds Suppress HPV Genome Replication via Disruption of Phospho-BRD4 Association with DNA Damage Response Factors
GEO Series GSE228786. Homo sapiens. 68 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Hi-C to Identify Interactions between Distant Genomic Loci due to BRD4-NUT-mediated Megadomain Formation
GEO Series GSE133163. Homo sapiens. 32 samples. Type: Other.
A Genome-Wide CRISPR Screen Identifies BRD4 as a Regulator of Cardiomyocyte Differentiation [in-vivo scRNA-seq]
GEO Series GSE184921. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
A Genome-Wide CRISPR Screen Identifies BRD4 as a Regulator of Cardiomyocyte Differentiation [CUT&RUN]
GEO Series GSE253329. Homo sapiens. 10 samples. Type: Other.
Knockdown of Brd4 or SEC affects the HMBA-induced global Pol II pausing release
GEO Series GSE76784. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Coordination of widespread transcription at enhancers and target genes through BRD4 (HiChIP)
GEO Series GSE214591. Homo sapiens. 6 samples. Type: Other.
Transcriptional profile of genes affected by the loss of Brd4 in the embryonic stem cells
GEO Series GSE59142. Mus musculus. 6 samples. Type: Expression profiling by array.
Bromodomain protein BRD4 is a transcriptional repressor of autophagy and lysosomal function
GEO Series GSE90444. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
BRD4 and MYB Inhibition Overcomes Venetoclax Resistance in EVI1-rearranged Acute Myeloid Leukemia
GEO Series GSE292744. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
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