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1,158 results for “cancer imaging”
Mueller matrix imaging combining optical parameters of mice non-melanoma skin cancer tissue
<p>The dataset consists of the Mueller matrix elements and optical parameters acquired from the backscattered light using a CCD camera and Mueller matrix imaging technique.</p><p>This dataset contains 90 samples including 20 feature vectors for SCC, 33 feature vectors for normal and 37 feature vectors for papilloma.</p>
ColoPola: A dataset of colorectal cancer polarimetric images (Mueller matrix elements) for colorectal cancer detection
<p><strong>ColoPola</strong> dataset is <strong>Colo</strong>rectal cancer <strong>Pola</strong>rimetric images dataset</p> <p>The dataset consists of 572 slices (specimens) with 20,592 images, 284 slices of which were designated as cancer samples and 288 as normal samples.</p> <p>Each sample has 36 polarimetric images (i.e., HH, HV, HP, HM, HR, HL, VH, VV, VP, VM, VR, VL, PH, PV, PP, PM, PR, PL, MH, MV, MP, MM, MR, ML, RH, RV, RP, RM, RR, RL, LH, LV, LP, LM, LR, and LL).</p> <p>Each folder in the <strong>ColoPola</strong> dataset consists of 36 polarimetric images. Each image is 1280x1024 pixels in size and was created in the TIF file format (HH.tif, HV.tif, ..., LL.tif). </p>
A dataset of colorectal cancer histopathological images
<p>The dataset contains the histopathological images of the ColoPola dataset (https://doi.org/10.5281/zenodo.10068018).</p> <p>CLCXYYZZNN_Hx</p> <p>CLC: colorectal (cancer) tissue</p> <p>NLC: normal tissue</p> <p>X - Times<br>YY - Sample number<br>ZZ - Serial number<br>NN - Image number<br>H - Magnification</p>
Infrared Chemical Image of a Breast Cancer Tissue Microarray
<p>This data set relates to an open access paper published in Analyst <em>Exploring AdaBoost and Random Forests machine learning approaches for infrared pathology on unbalanced data sets</em> by Jiayi Tang, Alex Henderson* and Peter Gardner. <a href="https://doi.org/10.1039/D0AN02155E"> https://doi.org/10.1039/D0AN02155E</a></p> <p>The files in this archive are mid-infrared spectroscopy chemical images of a breast cancer tissue microarray. The tissue microarray is BR20832 from Biomax. <a href="http://www.biomax.us/tissue-arrays/Breast/BR20832">http://www.biomax.us/tissue-arrays/Breast/BR20832</a></p> <p>Processed versions of these data in MATLAB file format can be found in another Zenodo archive at <a href="https://doi.org/10.5281/zenodo.4730312">https://doi.org/10.5281/zenodo.4730312</a></p> <p>This processed data refers to a paper published in Analyst</p>
2 million histological images of breast cancer tumors with her2 labels
<p><strong>Data Description</strong><br> This is a 2 million set of non-overlapping image patches from hematoxylin & eosin (H&E) stained histological images of human breast cancer tumor tissue.</p> <p>The anonymized dataset comes from a cohort of BC patients from the A. C. Camargo Cancer Center (ACCCC, N = 504). All patients were treated for breast cancer at the ACCCC between 2019 and 2021. As part of their diagnosis, in HER2 IHC score 2+ cases, patients' HER2 status was determined following the ASCO guidelines updated in 2018, with visual evaluation of IHC assay and either a FISH or DDISH test. All cases with metastasis or neoadjuvant treatment were excluded.</p> <p>A total of 426 H&E stained high resolution images (40x magnification) were scanned from biopsy and resection tissue samples with a Leica Aperio AT2 scanner. Ethical approval of the ACCCC study was given by the ethics committee of the Fundação Antônio Prudente. We divided the cases into the following 3 groups according to the results of the IHC and ISH tests: HER2-negative, HER2-low and HER2-high.</p> <p>The slides were divided into 256 px x 256 px tiles at 0.5 um/pixel magnification. Then, we used a custom trained ConvNext-tiny neural network to only include tiles from the tumor region and its environment, generating a total of 2051877 image patches.</p> <p>A sample is considered her2-negative with an IHC score of 0; her2-low with an IHC score of 1+ or an IHC score of 2+ with a negative ISH-based test result, and her2-high with an IHC score of 2+ with a positive ISH-based test or an IHC score of 3+.</p> <p>The accompanying code used for training the models is available at https://github.com/tojallab/wsi-mil</p>
Vectra Polatis image of human colorectal cancer (CRC1) from: A SIMPLI (Single-cell Identification from MultiPLexed Images) approach for spatially resolved tissue phenotyping at single-cell resolution.
<p>Two 4 µm thick serial sections were cut from CRC1 FFPE block using a microtome. The first slide was dewaxed and rehydrated before carrying out HIER with Antigen Retrieval Reagent-Basic (R&D Systems). The tissue was then blocked and incubated with the anti-CD3 antibody (Dako, Supplementary Table 2) followed by horseradish peroxidase (HRP) conjugated anti-rabbit antibody (Dako) and stained with 3,3' diaminobenzidine (DAB) substrate (Abcam) and haematoxylin. Areas with CD3<sup>+</sup> infiltration in the proximity of the tumour invasive margin were identified by a clinical pathologist (M. R-J.)</p> <p>The second slide was stained with a panel of six antibodies (CD8, PD1, Ki67, PDL1, CD68, GzB, Supplementary Table 2), Opal fluorophores and 4’,6-diamidino-2-phenylindole (DAPI) on a Ventana Discovery Ultra automated staining platform (Roche). Expected expression and cellular localisation of each marker as well as fluorophore brightness were used to minimise fluorescence spillage upon antibody-Opal pairing. Following a one-hour incubation at a 60°C, the slide was subjected to an automated staining protocol on an autostainer. The protocol involved deparaffinisation (EZ-Prep solution, Roche), HIER (DISC. CC1 solution, Roche) and seven sequential rounds of: one hour incubation with the primary antibody, 12 minutes incubation with the HRP-conjugated secondary antibody (DISC. Omnimap anti-Ms HRP RUO or DISC. Omnimap anti-Rb HRP RUO, Roche) and 16 minute incubation with the Opal reactive fluorophore (Akoya Biosciences). For the last round of staining, the slide was incubated with Opal TSA-DIG reagent (Akoya Biosciences) for 12 minutes followed by Opal 780 reactive fluorophore for our hour (Akoya Biosciences). A denaturation step (100°C for 8 minutes) was introduced between each staining round in order to remove the primary and secondary antibodies from the previous cycle without disrupting the fluorescent signal. The slide was counterstained with DAPI (Akoya Biosciences) and coverslipped using ProLong Gold antifade mounting media (Thermo Fisher Scientific). The Vectra Polaris automated quantitative pathology imaging system (Akoya Biosciences) was used to scan the labelled slide. Six fields of view, within the area selected by the pathologist, were scanned at 20x and 40x magnification using appropriate exposure times and loaded into inForm{Kramer, 2018 #23} for spectral unmixing and autofluorescence isolation using the spectral libraries. After spectral unmixing and merging of six 20x fields of view for a total of >5mm<sup>2</sup> ROI (Table 2), one single-tiff image was extracted for each marker and its intensity was rescaled from 0 to 1 with custom R scripts.</p>
Microscope images of human cancer cell lines (U2OS and HL-60)
<p>This is a dataset that contains microscope images from two cell lines, namely, a human osteosarcoma cell line (U2OS) and a human leukemia cell line (HL-60). The dataset was originally prepared for the cell counting task. It contains 165 labeled images (training: 133, test: 32).</p> <p>The file contains three folders:</p> <p>- training: 165 labeled images in .tiff format;<br> - test: 32 labeled images in .tiff format.</p> <p>Each labeled image has the following name: X.Y.N.tiff</p> <p>where:<br> X - the name of the human cancer cell line;<br> Y - a condition identifier (irrelevant);<br> N - the cell count.</p> <p><br> If you use this dataset, please cite the following paper:</p> <ul> <li>Lavitt F, Rijlaarsdam DJ, van der Linden D, Weglarz-Tomczak E, Tomczak JM. Deep Learning and Transfer Learning for Automatic Cell Counting in Microscope Images of Human Cancer Cell Lines. <em>Applied Sciences</em>. 2021; 11(11):4912. https://doi.org/10.3390/app11114912</li> </ul>
Quantum Cascade Laser Spectral Histopathology: Breast Cancer Diagnostics Using High Throughput Chemical Imaging
<p>Fourier transform infrared (FT-IR) microscopy, coupled with machine learning approaches, has been demonstrated to be a powerful technique for identifying abnormalities in human tissue. The ability to objectively identify the prediseased state, and diagnose cancer with high levels of accuracy, has the potential to revolutionise current histopathological practice. Despite recent technological advances in FT-IR microscopy, sample throughput and speed of acquisition are key barriers to clinical translation. Wide-field quantum cascade laser (QCL) infrared imaging systems with large focal plane array detectors utilising discrete frequency imaging, have demonstrated that large tissue microarrays (TMA) can be imaged in a matter of minutes. However this ground breaking technology is still in its infancy and its applicability for routine disease diagnosis is, as yet, unproven. In light of this we report on a large study utilising a breast cancer TMA comprised of 207 different patients. We show that by using QCL imaging with continuous spectra acquired between 912 and 1800 cm<sup>-1</sup>, we can accurately differentiate between 4 different histological classes. We demonstrate that we can discriminate between malignant and non-malignant stroma spectra with high sensitivity (93.56%) and specificity (85.64%) for an independent test set. Finally, we classify each core in the TMA and achieve high diagnostic accuracy on a patient basis with 100% sensitivity and 86.67% specificity. The absence of false negatives reported here opens up the possibility of utilising high throughput chemical imaging for cancer screening, thereby reducing pathologist workload and improving patient care.</p>
Imaging Mass Cytometry Dataset of exhausted and non-exhausted breast cancer microenvironments
<p>A cohort of human breast tumor samples were annotated as having an "exhausted" or "non-exhausted" immune environment based on CyTOF characterization of T cell phenotypes (see Wagner et al. 2019). 12 samples (6 exhausted, 6 non-exhausted) were then selected for further analysis by Imaging Mass Cytometry (IMC) with the goal to compare the two immune environment types and to comprehensively characterize exhaustion-associated spatial features of the tumor microenvironment. For IMC, two consecutive FFPE sections of each sample were stained with two different antibody panels (Protein Panel and RNAscope Panel), and 4-10 regions of interest (ROIs, 1mm x 1mm) were measured on each section. ROIs on consecutive sections were registered manually to be as spatially close as possible.</p>
Data on the detection of clinically significant prostate cancer by magnetic resonance imaging (MRI)-guided targeted and systematic biopsy
<p>This is a dataset from the original publication “Reasons for missing clinically significant prostate cancer by targeted magnetic resonance imaging/ultrasound fusion-guided biopsy”. From 01/2014 to 04/2019 a sample collective of 785 patients with 3T multiparametric magnetic resonance imaging (mp-MRI) of the prostate and subsequent combined systematic biopsy (SB) and magnetic resonance imaging/ultrasound (US) fusion-guided biopsy (TB) was retrospectively analyzed. Prostate carcinoma (PCa) detection by TB and/or additional SB was analyzed.</p>
Multi-modal image analysis for large scale cancer tissue studies within IMMUcan: multiplex immunofluorescence images
<p>In cancer research, multiplexed imaging has enabled the in-depth characterization of the tumor microenvironment (TME) and how it relates to patient prognosis. However, standardized, multi-modal data from large numbers of patients to identify robust biomarkers is missing. To provide such data across five cancer indications, the IMMUcan consortium performs broad molecular and cellular spatial profiling of thousands of cancer samples. Two reproducible and scalable workflows have been developed for whole slide multiplexed immunofluorescence (mIF) and imaging mass cytometry (IMC) to overcome challenges of reproducibility and scalability. For mIF we developed IFQuant, a web-based tool optimized for user-friendliness and reproducibility. This Zenodo record contains the mIF images and IFQuant settings to reproduce the results presented in the referenced publication. The companion IMC dataset is available as a joint Zenodo record.</p>
100,000 histological images of human colorectal cancer and healthy tissue
<p><strong>Data Description "NCT-CRC-HE-100K"</strong></p> <ul> <li>This is a set of 100,000 non-overlapping image patches from hematoxylin & eosin (H&E) stained histological images of human colorectal cancer (CRC) and normal tissue.</li> <li>All images are 224x224 pixels (px) at 0.5 microns per pixel (MPP). All images are color-normalized using Macenko's method (http://ieeexplore.ieee.org/abstract/document/5193250/, DOI <a href="https://doi.org/10.1109/ISBI.2009.5193250">10.1109/ISBI.2009.5193250</a>).</li> <li>Tissue classes are: Adipose (ADI), background (BACK), debris (DEB), lymphocytes (LYM), mucus (MUC), smooth muscle (MUS), normal colon mucosa (NORM), cancer-associated stroma (STR), colorectal adenocarcinoma epithelium (TUM).</li> <li>These images were manually extracted from N=86 H&E stained human cancer tissue slides from formalin-fixed paraffin-embedded (FFPE) samples from the NCT Biobank (National Center for Tumor Diseases, Heidelberg, Germany) and the UMM pathology archive (University Medical Center Mannheim, Mannheim, Germany). Tissue samples contained CRC primary tumor slides and tumor tissue from CRC liver metastases; normal tissue classes were augmented with non-tumorous regions from gastrectomy specimen to increase variability.</li> </ul> <p><strong>Ethics statement "NCT-CRC-HE-100K"</strong></p> <p>All experiments were conducted in accordance with the Declaration of Helsinki, the International Ethical Guidelines for Biomedical Research Involving Human Subjects (CIOMS), the Belmont Report and the U.S. Common Rule. Anonymized archival tissue samples were retrieved from the tissue bank of the National Center for Tumor diseases (NCT, Heidelberg, Germany) in accordance with the regulations of the tissue bank and the approval of the ethics committee of Heidelberg University (tissue bank decision numbers 2152 and 2154, granted to Niels Halama and Jakob Nikolas Kather; informed consent was obtained from all patients as part of the NCT tissue bank protocol, ethics board approval S-207/2005, renewed on 20 Dec 2017). Another set of tissue samples was provided by the pathology archive at UMM (University Medical Center Mannheim, Heidelberg University, Mannheim, Germany) after approval by the institutional ethics board (Ethics Board II at University Medical Center Mannheim, decision number 2017-806R-MA, granted to Alexander Marx and waiving the need for informed consent for this retrospective and fully anonymized analysis of archival samples).</p> <p><strong>Data set "CRC-VAL-HE-7K"</strong></p> <p>This is a set of 7180 image patches from N=50 patients with colorectal adenocarcinoma (no overlap with patients in NCT-CRC-HE-100K). It can be used as a validation set for models trained on the larger data set. Like in the larger data set, images are 224x224 px at 0.5 MPP. All tissue samples were provided by the NCT tissue bank, see above for further details and ethics statement.</p> <p><strong>Data set "NCT-CRC-HE-100K-NONORM"</strong></p> <p>This is a slightly different version of the "NCT-CRC-HE-100K" image set: This set contains 100,000 images in 9 tissue classes at 0.5 MPP and was created from the same raw data as "NCT-CRC-HE-100K". However, no color normalization was applied to these images. Consequently, staining intensity and color slightly varies between the images. Please note that although this image set was created from the same data as "NCT-CRC-HE-100K", the image regions are not completely identical because the selection of non-overlapping tiles from raw images was a stochastic process.</p> <p><strong>General comments</strong></p> <p>Please note that the classes are only roughly balanced. Classifiers should never be evaluated based on accuracy in the full set alone. Also, if a high risk of training bias is excepted, balancing the number of cases per class is recommended.</p>
Supplementary material - Non-invasive Multimodal Imaging Reveals Early Therapy-Induced Senescence in Human Cancer Cells
<p>The repository features .xls and .txt worksheets including all the data used through this work and reported in the manuscript figures and graphs. More precisely, we included the following: </p> <ul> <li>Figure 2. Raw pixel-wise signals detected in NLO images of TIS cells control cells that were used to perform the colocalization graphs and analyses reported. We describe the average colocalization of SRS and F-CARS signals, and TPEF and E-CARS signals, in both phenotypes.</li> <li>Figure 4. Raw data from image analyses of TPEF and SRS channels of multimodal NLO images, divided in 5 different time points over the therapy follow-up period. The data describe the early rearrangement of mitochondria (TPEF) and lipid vesicles (SRS) in TIS cells, with respect to control counterparts.</li> <li>Figure 6. Raw data from image analyses of QPI images, divided in 4 different time points over the therapy follow-up period. The data describe the early morphological modifications of TIS cells, with respect to control counterparts.</li> </ul>
Data for 'Deriving spatial features from in situ proteomics imaging to enhance cancer survival analysis'
<p>Additional data for 'Deriving spatial features from in situ proteomics imaging to enhance cancer survival analysis'</p>
F-18 Fluorothymidine PET Imaging for Early Evaluation of Response to Therapy in Head & Neck Cancer Patients
ClinicalTrials.gov study NCT00721799. IPD Sharing: NO. Countries: 1. Publications: 3.
Cervical intraepithelial neoplasia acetic acid white images - pre-cancerous lesion three-class classification
Open the record for dataset details and reuse information.
Multi-breath 4DCT images of lung cancer patients
<p><strong>Multi-breath 4DCT images of six non-small cell lung cancer (NSCLC) patients.</strong></p><p>Breathing motion has been transferred across longitudinal imaging to generate new 4DCT images sampling five consecutive breaths.</p><p>This dataset is the result of processing six subjects selected from the 4D-Lung dataset published in The Cancer Imaging Archive: <a href="https://doi.org/10.7937/K9/TCIA.2016.ELN8YGLE">https://doi.org/10.7937/K9/TCIA.2016.ELN8YGLE </a>Hugo et al. (2016).</p><p>Data generated within the project "New concept for adaptive real time tumour tracking" funded by the Swiss National Science Foundation (SNSF) under grant agreement 200021_185082: <a href="https://data.snf.ch/grants/grant/185082">https://data.snf.ch/grants/grant/185082</a> </p><p> </p>
Multiplexed imaging mass cytometry analysis characterizes the vascular niche in pancreatic cancer
<p>All data supporting the publication: "Multiplexed imaging mass cytometry analysis characterizes the vascular niche in pancreatic cancer."</p><p>1. Fully_Processed_OME.TIFF: This folder contains the OME.TIFF files with all markers after compensation and hot pixel removal for visualization of the data. These can be opened with QuPath and other software. </p><p>2. PDAC_IMC_Seurat_FINAL.rds: Seurat object of all cells included in the analysis with cell type and neighborhood annotations, and unintegrated and rPCA-integrated UMAP reductions. </p><p>3. Raw_Data_TIFF_Files: All raw individual TIFF files from the image acquisition</p><p>4. ROI_Selection: Brightfield and IHC images of individual samples showing where the ROIs for each sample are collected </p><p>5. Segmentation_Files: All relevant segmentation files from Mesmer for nuclear and whole cell segmentation. </p><p>6. H&E Images for each case scanned at 40x </p>
Pan-Cancer-Nuclei-Seg-DICOM: DICOM converted Dataset of Segmented Nuclei in Hematoxylin and Eosin Stained Histopathology Images
<div> <p>This dataset corresponds to a collection of images and/or image-derived data available from National Cancer Institute <a href="https://portal.imaging.datacommons.cancer.gov/">Imaging Data Commons (IDC)</a> [1]. This dataset was converted into DICOM representation and ingested by the IDC team. You can explore and visualize the corresponding images using IDC Portal here: <a href="https://portal.imaging.datacommons.cancer.gov/explore/filters/?analysis_results_id=Pan-Cancer-Nuclei-Seg-DICOM" target="_blank" rel="noopener">Pan-Cancer-Nuclei-Seg-DICOM</a>. You can use the manifests included in this Zenodo record to download the content of the collection following the <strong>Download instructions</strong> below.</p> <h3>Collection description</h3> </div> <div> <div>This collection contains automatic nucleus segmentation data of 5,060 whole slide tissue images of 10 cancer types earlier published in [2] (<a href="https://doi.org/10.7937/TCIA.2019.4A4DKP9U">https://doi.org/10.7937/TCIA.2019.4A4DKP9U</a>) stored in DICOM Bulk Annotation and DICOM Segmentation formats.</div> <div> </div> <div>DICOM Bulk Annotation nuclei annotations are stored as closed polygons along with the area of each nuclei. DICOM Segmentation version contains binary segmentations obtained by rasterizing the polygon contours. </div> <div> </div> <div>The annotations correspond to digital pathology images from the TCGA-BLCA,TCGA-BRCA,TCGA-CESC,TCGA-COAD,TCGA-GBM,TCGA-LUAD,TCGA-LUSC,TCGA-PAAD,TCGA-PRAD,TCGA-READ,TCGA-SKCM,TCGA-STAD,TCGA-UCEC,TCGA-UVM collections available in NCI Imaging Data Commons.</div> <div> </div> <div>To learn how these files are organized and how to access the content programmatically, see this documentation page: <a href="https://highdicom.readthedocs.io/en/latest/ann.html">https://highdicom.readthedocs.io/en/latest/ann.html</a>.</div> <div> </div> <div>Conversion of the nuclei segmentations from the original format into DICOM ANN and SEG representations was done using the code available in <a href="https://doi.org/10.5281/zenodo.13871765">10.5281/zenodo.10632181</a>.</div> <div> </div> <div>Annotations corresponding to this container ID in the source failed to convert due to the pixel matrix being too large to store: <code>TCGA-OL-A66K-01Z-00-DX1</code></div> <div> </div> <div>The following container IDs from the source annotations have failed due to inability to find the annotated images using the container IDs:</div> <div> <pre><code>TCGA-CU-A3QU-01Z-00-DX1 TCGA-A2-A0D1-01Z-00-DX1 TCGA-AQ-A1H2-01Z-00-DX1 TCGA-AQ-A1H2-01Z-00-DX1 TCGA-AQ-A1H3-01Z-00-DX1 TCGA-AQ-A1H3-01Z-00-DX1 TCGA-BH-A0B2-01Z-00-DX1 TCGA-E2-A15E-01Z-00-DX1 TCGA-E2-A1IP-01Z-00-DX1 TCGA-F4-6857-01Z-00-DX1 TCGA-12-0773-01Z-00-DX4 TCGA-35-3621-01Z-00-DX1 TCGA-49-4486-01Z-00-DX1 TCGA-33-4587-01Z-00-DX1 TCGA-D9-A1X3-01Z-00-DX1 TCGA-D9-A1X3-01Z-00-DX2 TCGA-D9-A4Z6-01Z-00-DX1 TCGA-EE-A17Y-01Z-00-DX1 TCGA-EE-A29R-01Z-00-DX1 TCGA-EE-A2A0-01Z-00-DX1 TCGA-EE-A2MS-01Z-00-DX1 TCGA-ER-A199-01Z-00-DX1 TCGA-ER-A1A1-01Z-00-DX1 TCGA-ER-A2NC-01Z-00-DX1 TCGA-FS-A1Z7-06Z-00-DX10 TCGA-FS-A1Z7-06Z-00-DX11 TCGA-FS-A1Z7-06Z-00-DX12 TCGA-FS-A1Z7-06Z-00-DX13 TCGA-FS-A1ZN-01Z-00-DX10 TCGA-FS-A1ZN-01Z-00-DX11 TCGA-FS-A1ZW-06Z-00-DX10 TCGA-FS-A1ZW-06Z-00-DX11 TCGA-GN-A261-01Z-00-DX1 TCGA-GN-A266-01Z-00-DX1 TCGA-GN-A268-01Z-00-DX1 TCGA-GN-A26A-01Z-00-DX1 TCGA-XV-AB01-01Z-00-DX1 TCGA-AJ-A23O-01Z-00-DX1 TCGA-AP-A056-01Z-00-DX1 TCGA-BK-A139-01Z-00-DX1 TCGA-E6-A1M0-01Z-00-DX1</code></pre> </div> <div> <h3>Files included</h3> <p>A manifest file's name indicates the IDC data release in which a version of collection data was first introduced. For example, <code>pan_cancer_nuclei_seg_dicom-collection_id-idc_v19-aws.s5cmd</code> corresponds to the annotations for th eimages in the <code>collection_id</code> collection introduced in IDC data release v19. DICOM Binary segmentations were introduced in IDC v20. If there is a subsequent version of this Zenodo page, it will indicate when a subsequent version of the corresponding collection was introduced.</p> <p>For each of the collections, the following manifest files are provided:</p> <ol> <li><code>pan_cancer_nuclei_seg_dicom-<collection_id>-idc_v20-aws.s5cmd</code>: manifest of files available for download from public IDC Amazon Web Services buckets</li> <li><code>pan_cancer_nuclei_seg_dicom-<collection_id>-idc_v20-gcs.s5cmd</code>: manifest of files available for download from public IDC Google Cloud Storage buckets</li> <li><code>pan_cancer_nuclei_seg_dicom-<collection_id>-idc_v20-dcf.dcf</code>: Gen3 manifest (for details see <a href="../records/Gen3%20manifest%20documentation">https://learn.canceridc.dev/data/organization-of-data/guids-and-uuids</a>)</li> </ol> <p>Note that manifest files that end in <code>-aws.s5cmd</code> reference files stored in Amazon Web Services (AWS) buckets, while <code>-gcs.s5cmd</code> reference files in Google Cloud Storage. The actual files are identical and are mirrored between AWS and GCP.</p> <h3>Download instructions</h3> <p>Each of the manifests include instructions in the header on how to download the included files.</p> <p>To download the files using <code>.s5cmd</code> manifests:</p> <ol> <li>install <a href="https://github.com/imagingdatacommons/idc-index" target="_blank" rel="noopener">idc-index</a> package: <code>pip install --upgrade idc-index</code></li> <li>download the files referenced by manifests included in this dataset by passing the <code>.s5cmd</code> manifest file: <code>idc download manifest.s5cmd</code></li> </ol> <p>To download the files using <code>.dcf</code> manifest, see manifest header.</p> <h3>Acknowledgments</h3> <p>Imaging Data Commons team has been funded in whole or in part with Federal funds from the National Cancer Institute, National Institutes of Health, under Task Order No. HHSN26110071 under Contract No. HHSN261201500003l.</p> <h3>References</h3> </div> </div> <div>[1] Fedorov, A., Longabaugh, W. J. R., Pot, D., Clunie, D. A., Pieper, S. D., Gibbs, D. L., Bridge, C., Herrmann, M. D., Homeyer, A., Lewis, R., Aerts, H. J. W. L., Krishnaswamy, D., Thiriveedhi, V. K., Ciausu, C., Schacherer, D. P., Bontempi, D., Pihl, T., Wagner, U., Farahani, K., Kim, E. & Kikinis, R. National cancer institute imaging data commons: Toward transparency, reproducibility, and scalability in imaging artificial intelligence. Radiographics 43, (2023).</div> <div> </div> <div>[2] Hou, L., Gupta, R., Van Arnam, J. S., Zhang, Y., Sivalenka, K., Samaras, D., Kurc, T., & Saltz, J. H. (2019). Dataset of Segmented Nuclei in Hematoxylin and Eosin Stained Histopathology Images of 10 Cancer Types [Data set]. The Cancer Imaging Archive. https://doi.org/10.7937/TCIA.2019.4A4DKP9U</div>
Tracking breast cancer cells migrating collectively and imaged in fluorescence with TrackMate-Cellpose
<p>Breast cancer cells migrating collectively.</p> <p>This dataset is used in a tutorial on using TrackMate and its cellpose integration to track such cells.</p> <p>See here for details: <a href="https://imagej.net/plugins/trackmate/trackmate-cellpose">https://imagej.net/plugins/trackmate/trackmate-cellpose</a> </p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.