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24 results for “cardiac electrophysiology”
Four-Chamber Human Heart Model for the Simulation of Cardiac Electrophysiology and Cardiac Mechanics
<p><strong>Changes in version 1.1 compared to version 1.0:</strong></p> <ul> <li>Ventricular fiber orientation changed to 66° on the endocardial and −41° on the epicardial surface</li> <li>Electrophysiology mesh was resampled</li> <li>Updated material tags in EP mesh</li> <li>Further details can be found in the <a href="https://github.com/KIT-IBT/CardioMechanics/tree/main">CardioMechanics GitHub repository</a> new reference paper:</li> </ul> <blockquote> <p>Gerach, T.; Loewe, A. Differential effects of mechano-electric feedback mechanisms on whole-heart activation, repolarization, and tension. <em>The Journal of Physiology</em> <strong>2024. </strong>https://doi.org/10.1113/JP285022 </p> </blockquote> <p>This repository contains a four-chamber model of the human heart which is ready to use for simulations of cardiac electrophysiology and cardiac mechanics problems. When using this dataset, please also cite the accompanying paper</p> <blockquote> <p>Gerach, T.; Schuler, S.; Fröhlich, J.; Lindner, L.; Kovacheva, E.; Moss, R.; Wülfers, E.M.; Seemann, G.; Wieners, C.; Loewe, A. Electro-Mechanical Whole-Heart Digital Twins: A Fully Coupled Multi-Physics Approach. <em>Mathematics</em> <strong>2021</strong>, <em>9</em>, 1247. https://doi.org/10.3390/math9111247</p> </blockquote> <p>The cardiac anatomy was manually segmented from magnetic resonance imaging (MRI) data of a 33 year old male volunteer. The volunteer provided informed consent and the study was approved by the IRB of Heidelberg University Hospital (Fritz et al., 2014).<br>The MRI data were acquired using a 1.5 T MR tomography system and consist of a static whole heart image stack taken during diastasis as well as time-resolved images in several long and short axis slices. Based on the segmentation, we first labeled the atria and the ventricles. The geometry was extended by a representation of the mitral valve, the tricuspid valve, the aortic valve and the pulmonary valve. Additionally, we closed the endo- and epicardial surfaces of the atria and added truncated pulmonary veins, vena cavae as well as the ascending aorta and pulmonary artery. Furthermore, we added a concentric layer of tissue around the entire heart which phenomenologically represents the influence of the pericardium and the surrounding tissue.</p> <p>Two tetrahedral meshes were created using Gmsh (Geuzaine et al., 2009): (1) the mechanical reference domain (<strong>M.vtu</strong>) with 128,976 elements (on average 3.17 mm edge length) and (2) the electrophysiological reference domain (<strong>EP.vtu</strong>) as a subset of M with 50,058,295 elements (on average 0.4 mm edge length).<br>We used rule-based methods to assign the myofiber orientation on EP: Wachter et al. (2015) was used for the atria and Bayer et al. (2012) for the ventricles. The fiber angle in the ventricles was chosen as +60° and -60° on the endocardial and epicardial surface, respectively. The sheet angle was set to -65° on the endocardium and 25° on the epicardium. Github repositories to these fiber generation tools are given in the sidebar. All geometry files are given in millimeter (mm).</p> <ul> <li><strong>Data:</strong><br>We provide time resolved data evaluated from cine MRI data, which can be used for model calibration. <ul> <li>Wall thickening (<strong>17AHA_WT.txt</strong>) / fractional wall thickening (<strong>17AHA_fractionalWT.txt</strong>) in the 17 AHA segments of the left ventricle</li> <li>Atrioventricular plane displacement (<strong>AVPD.txt</strong>) and velocity (<strong>AVPV.txt</strong>) as well as the displacement of all tracked points used for AVPD calculation (<strong>AVPD_trackedPoints.txt</strong>)</li> <li>Left and right ventricular volume (<strong>Volume_LV_RV.txt</strong>). RV volume is only available for end-diastole and end systole.</li> </ul> </li> <li><strong>Surfaces:</strong><br>This directory contains *.stl files with triangulated surfaces on which boundary conditions can be applied. <ul> <li><strong>cavityXX.stl</strong>: blood volume of the LV, RV, LA, RA</li> <li><strong>epicard.stl</strong>: the whole epicardium</li> <li><strong>outerPeri.stl</strong> and <strong>outerTrunks.stl</strong>: surfaces for Dirichlet boundary conditions</li> <li><strong>master.stl </strong>and <strong>slave.stl</strong>: surfaces used for the frictionless contact problem described in Fritz et al. (2014)</li> </ul> </li> <li><strong>TetGen:</strong><br>Contains the geometry <strong>M.vtu</strong> in the TetGen file format. T4 mesh with 4 node tetrahedrons and 3 node triangles. <ul> <li>.bases: fiber, sheet, and normal orientation at quadrature points of all elements</li> <li>.node: vertex coordinates</li> <li>.ele: list of tetrahedra</li> <li>.sur: list of triangles</li> </ul> </li> <li><strong>EP.vtu:</strong><br>Contains the cell arrays Fiber and Material.</li> <li><strong>M.vtu:</strong><br>Contains the cell arrays Fiber, Sheet, Sheetnormal, Material, and Label.</li> <li><strong>LabelIDs.txt:</strong><br>List of Label and Material identification numbers and corresponding anatomical structures.</li> </ul> <p> </p>
Figure 1 in Cardiotoxic effects of enrofloxacin on electrophysiological activity, cardiac markers, oxidative stress, and haematological findings in rabbits
Figure 1. Histological examination of rabbit heart in the negative control (A) shows normal morphology. Histological examination of rabbit heart in group 1 (B) and group 2 (C) shows normal morphology except for some minor abnormalities including hyperaemia in some areas (H&E, 400×).
Oxytocin Effects on Cardiac Electrophysiology
ClinicalTrials.gov study NCT01780337. IPD Sharing: NO. Countries: 1. Publications: 15.
Non-invasive Tool to Assess Electrophysiological Mechanisms in Cardiac Arrhythmias
ClinicalTrials.gov study NCT05772182. IPD Sharing: NO. Countries: 1. Publications: 0.
Stanford Cardiac Invasive Electrophysiology Novel Computer Experience
ClinicalTrials.gov study NCT03549806. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Effects of Dexmedetomidine on Cardiac Electrophysiology in Patients Under General Anesthesia During Perioperative Period
ClinicalTrials.gov study NCT04577430. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Role of Electrophysiology Testing in Survivors of Unexplained Cardiac Arrest
ClinicalTrials.gov study NCT03079414. IPD Sharing: NO. Countries: 3. Publications: 3.
Electrophysiological Mechanisms and Inhibitory Cardiac Syncope
ClinicalTrials.gov study NCT02861274. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Cardiac Electrophysiological Study
ClinicalTrials.gov study NCT00616629. IPD Sharing: Not stated. Countries: 4. Publications: 0.
Cardiac Radiotherapy-Induced Epigenetic Memory Underlies Electrophysiologic and Metabolic Reprogramming [RNA-seq]
GEO Series GSE291280. Homo sapiens; Mus musculus. 108 samples. Type: Expression profiling by high throughput sequencing.
Cardiac Radiotherapy-Induced Epigenetic Memory Underlies Electrophysiologic and Metabolic Reprogramming [ATAC-seq]
GEO Series GSE291268. Mus musculus; Homo sapiens. 50 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Optimization of Cardiac Resynchronization Therapy by Non-Invasive Imaging of Cardiac Electrophysiology
ClinicalTrials.gov study NCT04662970. IPD Sharing: NO. Countries: 1. Publications: 0.
Predictive Electrophysiological Score of the Neurological Prognosis Post Cardiac Arrest
ClinicalTrials.gov study NCT02886039. IPD Sharing: YES. Countries: 1. Publications: 0.
ElectroPhySiological Characterization Of the Arrhythmia Substrate for Sudden Cardiac Death PrEdiction
ClinicalTrials.gov study NCT07020702. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Clinical Study on the Use of a Domestically Produced Three-dimensional Cardiac Electrophysiological Mapping System Combined With Pressure Monitoring Technology and Star Mapping Technology for the Tr
ClinicalTrials.gov study NCT07039032. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Effect of Back Massage Before the Cardiac Electrophysiological Procedure
ClinicalTrials.gov study NCT05113992. IPD Sharing: NO. Countries: 1. Publications: 0.
Impact of Virtual Reality in Cardiac Electrophysiology
ClinicalTrials.gov study NCT07009951. IPD Sharing: NO. Countries: 1. Publications: 0.
RCT Comparing Remimazolam With Propofol Under EEG DSA Guidance During Cardiac Electrophysiology Studies and Ablation
ClinicalTrials.gov study NCT06700681. IPD Sharing: NO. Countries: 1. Publications: 0.
Electrophysiological Phenotyping Of Patients at Risk of Ventricular Arrhythmia and Sudden Cardiac Death
ClinicalTrials.gov study NCT03910725. IPD Sharing: NO. Countries: 1. Publications: 0.
Characterization of Cardiac Electrophysiological Effects of Autonomic Neuromodulation
ClinicalTrials.gov study NCT05377216. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
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OpenNeuro
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