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135 results for “cardioprotection”
Heart Failure eQTLs companion to "Pathologic gene network rewiring implicates PPP1R3A as a central cardioprotective factor in pressure overload heart failure"
<p>These are the results of a QTL analysis companion to "Pathologic gene network rewiring implicates PPP1R3A as a central cardioprotective factor in pressure overload heart failure". We performed RNA expression measurements and obtained genotype information in genome-wide markers for 313 patients (177 failing hearts , 136 donor, non-failing [control] hearts) using Affymetrix expression and Affymetrix Human 6.0 respectively.<strong> </strong>Prior to eQTL discovery, we used PEER to find hidden covariates that could confound signals in our data as well as filtering any genotypes with major allele frequencies less than 5%. To test associations between gene expression in each cohort separately, we used QTLTools with an additive model accounting for gender, age, sample site, and the PEER factors as covariates. We corrected for eQTL multiple association testing using a 10000 permutations per locus in a 2 megabase window and a false discovery rate cutoff of 5%. To select the number of PEER factors, we performed the full analysis multiple times from 1 to 15 PEER factors and observed a saturation of new QTLs being discovered when using 10 factors.</p> <p>Four files are provided, two for each cohort (cases and controls):</p> <p>- peer_[cases|controls]_nominal.txt: Nominal associations with a p-value threshold of 0.001</p> <p>- peer_[cases|controls]_permutations_all.significant.txt: All significant associations detected after the QTLtools permutation test.</p> <p>The column names are those from QTLtools, in order:</p> <p><br> 1. The phenotype ID<br> 2. The chromosome ID of the phenotype<br> 3. The start position of the phenotype<br> 4. The end position of the phenotype<br> 5. The strand orientation of the phenotype<br> 6. The total number of variants tested in cis<br> 7. The distance between the phenotype and the tested variant (accounting for strand orientation)<br> 8. The ID of the tested variant ( in Affy 6.0 SNP ids)<br> 9. The chromosome ID of the variant<br> 10. The start position of the variant<br> 11. The end position of the variant<br> 12. The nominal P-value of association between the variant and the phenotype<br> 13. The corresponding regression slope<br> 14. A binary flag equal to 1 is the variant is the top variant in cis</p>
An Adapted Brazilian Cardioprotective Diet, Phytosterols and Krill Oil in Familial Hypercholesterolemia (DICA-FH)
ClinicalTrials.gov study NCT06331195. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Cardioprotective and Mental Health Benefits of the MIND Diet Combined With Forest Bathing
ClinicalTrials.gov study NCT06222632. IPD Sharing: YES. Countries: 1. Publications: 18.
Risk-Guided Cardioprotection With Carvedilol in Breast Cancer Patients Treated With Doxorubicin and/or Trastuzumab
ClinicalTrials.gov study NCT04023110. IPD Sharing: NO. Countries: 1. Publications: 1.
Pilot Study of an NTproBNP Guided Strategy of Cardioprotection
ClinicalTrials.gov study NCT04737265. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Cardioprotective Activities Of Whole Eggs On Vascular Endothelial Function In Prediabetic Adults
ClinicalTrials.gov study NCT02364570. IPD Sharing: Not stated. Countries: 1. Publications: 12.
Cardioprotective Benefits of Carvedilol-CR or Valsartan Added to Lisinopril
ClinicalTrials.gov study NCT00657241. IPD Sharing: NO. Countries: 1. Publications: 1.
Cardioprotective and Anti-inflammatory Effects of FAM3D in Myocardial Ischemia-Reperfusion Injury
<p>Human plasma samples from patients with acute myocardial infarction (AMI) were obtained at 14-28 days and 6 months after index event, as part of the OMEGA-REMODEL Trial [Heydari, B., et al., <em>Effect of Omega-3 Acid Ethyl Esters on Left Ventricular Remodeling After Acute Myocardial Infarction: The OMEGA-REMODEL Randomized Clinical Trial.</em> Circulation, 2016. <strong>134</strong>(5): p. 378-91]. Patients were enrolled across 3 tertiary-care centers in Boston, MA, with each of their Institutional Review Boards approving the study (Brigham and Women’s, Massachusetts General, and Beth Israel Deaconess Medical Center hospitals). All patients received standard medical therapy per discretion of their attending cardiologists. Please refer to Heydari et al. for inclusion and exclusion criteria, and study endpoints. The primary study endpoint was change in left ventricular end-systolic volume indexed to body surface area (LVESVI, mL/m2) by cardiac MRI over 6 months. Blood samples were anticoagulated with EDTA, and plasma immediately stored at -80C with minimal number of freeze-thaw cycles before proteomic analysis. An aptamer-based proteomics platform (version 3,Somalogic) was used to measure relative levels of 1,305 analytes, corresponding to 1,1272 unique human proteins.</p>
Adenosine Cardioplegia; Improved Cardioprotection?
ClinicalTrials.gov study NCT01123525. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Chronic Intradialytic Exercise : a Cardioprotective Role
ClinicalTrials.gov study NCT04697459. IPD Sharing: NO. Countries: 1. Publications: 1.
Clinical Study to Evaluate The Cardioprotective Effect of Pentoxifylline Against Doxorubicin Induced Cardiotoxicity in Breast Cancer Patients
ClinicalTrials.gov study NCT07137793. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
PeRiOperaTivE CardioproTection With Ivabradine in Non-cardiac Surgery
ClinicalTrials.gov study NCT04436016. IPD Sharing: NO. Countries: 1. Publications: 6.
Study of Microvascular Dysfunction, CFR and Cardioprotective Effect of Early Administration of Esmolol in MI
ClinicalTrials.gov study NCT06376630. IPD Sharing: Not stated. Countries: 1. Publications: 13.
Cardioprotective Effects of Green Tea Versus Maté Intake
ClinicalTrials.gov study NCT00933647. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Cardioprotective Properties of ELAIOTSIPOURA
ClinicalTrials.gov study NCT04440202. IPD Sharing: YES. Countries: 1. Publications: 2.
Early Cardioprotective Effect of Sevoflurane
ClinicalTrials.gov study NCT00477737. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Pre- or Per-dialytic Physical Exercise : a Cardioprotective Role?
ClinicalTrials.gov study NCT04831021. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Cardioprotective Effects of Freeze Dried Grape Powder on Blood Pressure and Plasma Lipids/Lipoproteins
ClinicalTrials.gov study NCT03659695. IPD Sharing: NO. Countries: 1. Publications: 15.
Propofol Cardioprotection for Type II Diabetics
ClinicalTrials.gov study NCT00734383. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Optimization of Cardioprotection in Diabetic Patients Undergoing Cardiac Surgery
ClinicalTrials.gov study NCT02407626. IPD Sharing: NO. Countries: 1. Publications: 10.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.