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93 results for “carotid stenosis”
Hydrogen sulfide release via the ACE inhibitor Zofenopril prevents intimal hyperplasia in human vein segments and in a mouse model of carotid artery stenosis
<p>The current strategies to reduce intimal hyperplasia (IH) principally rely on local drug delivery, in endovascular approach. The oral angiotensin converting enzyme inhibitor (ACEi) Zofenopril has additional effects compared to other non-sulfyhydrated ACEi to prevent intimal hyperplasia and restenosis. Given the number of patients treated with ACEi worldwide, these findings call for further prospective clinical trials to test the benefits of sulfhydrated ACEi over classic ACEi for the prevention of restenosis in hypertensive patients.</p> <p>Abstract</p> <p>Objectives</p> <p>Hypertension is a major risk factor for intimal hyperplasia (IH) and restenosis following vascular and endovascular interventions. Pre-clinical studies suggest that hydrogen sulfide (H2S), an endogenous gasotransmitter, limits restenosis. While there is no clinically available pure H2S releasing compound, the sulfhydryl-containing angiotensin-converting enzyme inhibitor Zofenopril is a source of H2S. Here, we hypothesized that Zofenopril, due to H2S release, would be superior to other non-sulfhydryl containing angiotensin converting enzyme inhibitor (ACEi), in reducing intimal hyperplasia in the context of hypertension.</p> <p>Materials</p> <p>Spontaneously hypertensive male Cx40 deleted mice (Cx40-/-) or WT littermates were randomly treated with Enalapril 20 mg (Mepha Pharma) or Zofenopril 30 mg (Mylan SA). Discarded human vein segments and primary human smooth muscle cells (SMC) were treated with the active compound Enalaprilat or Zofenoprilat.</p> <p>Methods</p> <p>IH was evaluated in mice 28 days after focal carotid artery stenosis surgery and in human vein segments cultured for 7 days ex vivo. Human primary smooth muscle cell (SMC) proliferation and migration were studied in vitro.</p> <p>Results</p> <p>Compared to control animals (intima/media thickness=2.3±0.33), Enalapril reduced IH in Cx40-/- hypertensive mice by 30% (1.7±0.35; p=0.037), while Zofenopril abrogated IH (0.4±0.16; p<.0015 vs. Ctrl and p>0.99 vs. sham-operated Cx40-/-mice). In WT normotensive mice, enalapril had no effect (0.9665±0.2 in control vs 1.140±0.27; p>.99), while Zofenopril also abrogated IH (0.1623±0.07, p<.008 vs. Ctrl and p>0.99 vs. sham-operated WT mice). Zofenoprilat, but not Enalaprilat, also prevented intimal hyperplasia in human veins segments ex vivo. The effect of Zofenopril on carotid and SMC correlated with reduced SMC proliferation and migration. Zofenoprilat inhibited the MAPK and mTOR pathways in SMC and human vein segments.</p> <p>Conclusion</p> <p>Zofenopril provides extra beneficial effects compared to non-sulfhydryl ACEi to reduce SMC proliferation and restenosis, even in normotensive animals. These findings may hold broad clinical implications for patients suffering from vascular occlusive diseases and hypertension.</p>
The associations of gene-gene interactions among the 6 variants in 3 genes related to inflammation and endothelial function with carotid stenosis were performed by the GMDR approach
<p><span>The associations of gene-gene interactions among the 6 variants in 3 genes related to inflammation and endothelial function with carotid stenosis were performed by the GMDR approach. The best model for carotid stenosis including <em>ITGA2</em> rs4865756 and <em>HABP2</em> rs7923349 scored 8/10 for cross-validation consistency and 10/10 for sign testing. </span></p>
Asymptomatic Carotid Stenosis: Cognitive Function and Plaque Correlates
ClinicalTrials.gov study NCT01353196. IPD Sharing: NO. Countries: 1. Publications: 1.
Revacept in Symptomatic Carotid Stenosis
ClinicalTrials.gov study NCT01645306. IPD Sharing: NO. Countries: 2. Publications: 12.
Optical Coherence Tomography Angiography Evaluation of Ocular Changes in Patients With Carotid Artery Stenosis
ClinicalTrials.gov study NCT04326842. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Urgent Carotid Endarterectomy (CEA) Versus Delayed CEA in Symptomatic Carotid Stenosis (SPREAD-STACI II)
ClinicalTrials.gov study NCT06767657. IPD Sharing: YES. Countries: 1. Publications: 10.
The associations of gene-gene interactions among the 6 variants in 3 genes related to inflammation and endothelial function with carotid stenosis were performed by the GMDR approach
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PET-MRI Imaging in Patients With Symptomatic Carotid Artery Stenosis
ClinicalTrials.gov study NCT03215550. IPD Sharing: NO. Countries: 1. Publications: 1.
Ocular Perfusion in Patients With Unilateral Carotid Artery Stenosis
ClinicalTrials.gov study NCT06398223. IPD Sharing: Not stated. Countries: 1. Publications: 14.
Ultrasonographic Morphology Assessment of Low-grade Carotid Stenosis
ClinicalTrials.gov study NCT05437991. IPD Sharing: NO. Countries: 1. Publications: 0.
Arachidonic Acid Metabolism in Carotid Stenosis Plaque in Diabetic Patients
ClinicalTrials.gov study NCT03202823. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Remote Ischemic Preconditioning on Cerebral Circulation Time in Patients With Severe Carotid Artery Stenosis (RIP-CCT)
ClinicalTrials.gov study NCT05451030. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Revascularization of Extracranial Carotid Artery Stenosis
ClinicalTrials.gov study NCT01994187. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Assessment of Carotid Artery Stenosis and Lower Limb Peripheral Ischemia Prior to CABG
ClinicalTrials.gov study NCT03516929. IPD Sharing: NO. Countries: 1. Publications: 1.
Lifestyle Modification Programme for Patients With Asymptomatic Carotid Artery Stenosis
ClinicalTrials.gov study NCT03929354. IPD Sharing: NO. Countries: 1. Publications: 7.
Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial - Hemodynamics (CREST-H)
ClinicalTrials.gov study NCT03121209. IPD Sharing: YES. Countries: 2. Publications: 2.
Improved Image Quality for Assessment of Carotid Artery Stenosis by Ultrafast Ultrasound FLOW Imaging
ClinicalTrials.gov study NCT06170580. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Revascularization Effect on CSVD Burden in Carotid Artery Stenosis
ClinicalTrials.gov study NCT06031610. IPD Sharing: NO. Countries: 1. Publications: 1.
EVA3S: Endarterectomy Versus Angioplasty in Patients With Severe Symptomatic Carotid Stenosis
ClinicalTrials.gov study NCT00190398. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Evaluation of the 3-in-1 Neuroguard IEP System for Carotid Artery Stenosis
ClinicalTrials.gov study NCT04142541. IPD Sharing: NO. Countries: 2. Publications: 1.
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OpenNeuro
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