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20 results for “chemogenetics”
Acetylcholine receptor based chemogenetics engineered for neuronal inhibition and seizure control assessed in mice
<p>Analysis scripts and underlying data used to produce the figures in our study entitled "Acetylcholine receptor based chemogenetics engineered for neuronal inhibition and seizure control assessed in mice", in Nature Communications. The listed project leaders can be contacted with any questions.</p>
Data from: The neural basis of resting-state fMRI functional connectivity in fronto-limbic circuits revealed by chemogenetic manipulation
<p>Included are raw neuroimaging and preprocessed neural recording data from "The neural basis of resting-state fMRI functional connectivity in fronto-limbic circuits revealed by chemogenetic manipulation" (see Related Works section; citation will be updated after publication). Please cite this paper if you use any of these data. Refer to the linked github repository for associated code.</p> <p>Neuroimaging data is organized in BIDS format and saved as NIfTI files. We used MION (monocrystalline iron oxide nanoparticle) as a contrast agent. Functional resting state files can be found in the 'func' folder for each imaging session. The final six runs are resting state data (the first two/three are short EPI sequences used to test that MION is present in the brain; all resting state data used in our analyses consist of 300 volumes). The first three of these six runs consist of baseline data with no drug treatment. Four through six are resting state data recorded after I.M. injection of vehicle (2% DMSO in saline), dechloroclozapine (DCZ) or clozapine-N-oxide (CNO). </p> <p>Neural recording data is separated into LFP data, organized by folder, and putative single units, organized the 'Sorted neurons' folder. LFP data folders are named by subject's intial and date of recording. Single units are labeled according to this same system. All data are stored in .mat format and can be opened in MATLAB. KB2.mat files store timing information: the first event in the KBD2 file indicates the start of baseline, pre-injection data acquisition, and the second event indicates the start of post-injection treatment data. The KB3.mat files contains the timing information of the drug injection. As with the fMRI data, we treated animals with I.M. injection of vehicle, DCZ, or CNO. </p> <p>Treatment information for both modalities is as follows. Neuroimaging: 2020/03/16 Animal L DCZ 1; 2020/05/27 Animal H vehicle 1; 2020/06/01 Animal L vehicle 1; 2020/06/08 Animal H DCZ 1; 2020/06/22 Animal L DCZ 2; 2020/06/24 Animal H vehicle 2; 2020/07/06 Animal L vehicle 2; 2020/07/08 Animal H DCZ 2; 2021/10/25 Animal L CNO; 2022/01/13 Animal H CNO. Neural recordings: 2022/04/14 Animal H DCZ 1; 2022/04/21 Animal H vehicle 1; 2022/05/12 Animal H DCZ 2; 2022/05/24 Animal H vehicle 2; 2022/06/03 Animal H CNO; 2022/08/18 Animal L vehicle 1; 2022/08/25 Animal L DCZ 1; 2022/09/01 Animal L DCZ 2; 2022/09/08 Animal L vehicle 2; 2022/09/22 Animal L CNO.</p>
Fig S4 hM4D(Gi) chemogenetic inhibition, in Regulation of REM Sleep by Inhibitory Neurons in the Dorsomedial Medulla
<p>Sleep recording data for hM4D(Gi) experiments. Associated with Figure S4.</p>
Raw and Preprocessed Data for the Paper "A chemogenetic approach for dopamine imaging with tunable sensitivity"
<p>This Dataset includes matlab variables as well as Excel tables containing all raw and preprocessed data</p>
Data from: Chemogenetic inhibition of the medial prefrontal cortex reverses the effects of REM sleep loss on sucrose consumption
Rapid eye movement (REM) sleep loss is associated with increased consumption of weight-promoting foods. The prefrontal cortex (PFC) is thought to mediate reward anticipation. However, the precise role of the PFC in mediating reward responses to highly palatable foods (HPF) after REM sleep deprivation is unclear. We selectively reduced REM sleep in mice over a 25–48 hr period and chemogenetically inhibited the medial PFC (mPFC) by using an altered glutamate-gated and ivermectin-gated chloride channel that facilitated neuronal inhibition through hyperpolarizing infected neurons. HPF consumption was measured while the mPFC was inactivated and REM sleep loss was induced. We found that REM sleep loss increased HPF consumption compared to control animals. However, mPFC inactivation reversed the effect of REM sleep loss on sucrose consumption without affecting fat consumption. Our findings provide, for the first time, a causal link between REM sleep, mPFC function and HPF consumption.
Data from: Chemogenetic interrogation of a brain-wide fear memory network in mice
Behavior depends on coordinated activity across multiple brain regions. Within such networks, highly connected hub regions are assumed to disproportionately influence behavioral output, although this hypothesis has not been systematically evaluated. Previously, by mapping brain-wide expression of the activity-regulated gene c-fos, we identified a network of brain regions co-activated by fear memory. To test the hypothesis that hub regions are more important for network function, here, we simulated node deletion in silico in this behaviorally defined functional network. Removal of high degree nodes produced the greatest network disruption (e.g., reduction in global efficiency). To test these predictions in vivo, we examined the impact of post-training chemogenetic silencing of different network nodes on fear memory consolidation. In a series of independent experiments encompassing 25% of network nodes (i.e., 21/84 brain regions), we found that node degree accurately predicted observed deficits in memory consolidation, with silencing of highly connected hubs producing the largest impairments.
Data from: Chemogenetic inhibition of the medial prefrontal cortex reverses the effects of REM sleep loss on sucrose consumption
Open the record for dataset details and reuse information.
Data from: Chemogenetic interrogation of a brain-wide fear memory network in mice
Open the record for dataset details and reuse information.
A chemogenetic screen for neuro-immune interactions in the gut: Trpv1+ nociceptor neurons control T regulatory cells
GEO Series GSE240982. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Krencik NPCs, iAstros, Chemogenetic iAstros, OptoNeurons
GEO Series GSE187436. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Mouse spinal cords transplanted with human iPS cell-derived neural cells with and without chemogenetic stimulations on 14-days and 42-days after spinal cord injury.
GEO Series GSE173244. Homo sapiens; Mus musculus. 13 samples. Type: Expression profiling by high throughput sequencing.
Chemogenetic tuning reveals optimal MAPK signaling for cell-fate programming
GEO Series GSE303587. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Chemogenetic activation of iBAT-projecting sympathetic neurons
GEO Series GSE310279. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
A Clinical Study of the Safety and Efficacy of Chemogenetics Therapy in the Treatment of Parkinson's Disease
ClinicalTrials.gov study NCT07085195. IPD Sharing: NO. Countries: 1. Publications: 0.
Chronic chemogenetic activation of the superior colliculus in glaucomatous mice: local and retrograde molecular signature
GEO Series GSE202012. Mus musculus. 82 samples. Type: Expression profiling by high throughput sequencing.
PhosphoRiboTrap sequencing data of chemogenetic MCH neuron activation
GEO Series GSE146019. Mus musculus. 22 samples. Type: Other.
Genes that were altered after chemogenetic activation of endogenous oxytocin in the dorsal horn
GEO Series GSE210528. Rattus norvegicus. 12 samples. Type: Expression profiling by high throughput sequencing.
Effects of optogenetic and chemogenetic LC activation on the hippocampal transcriptome
GEO Series GSE218313. Mus musculus. 106 samples. Type: Expression profiling by high throughput sequencing.
Chemogenetic activation of astrocytes in the hippocampus and cortex changes the transcriptome of microglia
GEO Series GSE154208. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Chronic, Chemogenetic Stimulation of The Nucleus Accumbens Produces Lasting Effects on Binge Drinking and Ameliorates Alcohol-Related Transcriptional and Morphological Changes
GEO Series GSE133115. Mus musculus. 45 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.