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11 results for “cholesterol biosynthesis pathway”
Supplementary Data: Evolution of the cholesterol biosynthesis pathway in animals
<p>Cholesterol plays essential roles in animal development and disease progression. Here, we characterize the evolutionary pattern of the canonical cholesterol biosynthesis pathway (CBP) in the animal kingdom using both genome-wide analyses and functional experiments. CBP genes in the basal metazoans were inherited from their last common eukaryotic ancestor and evolutionarily conserved for cholesterol biosynthesis. The genomes of both the basal metazoans and deuterostomes retain almost the full set of CBP genes, while Cnidaria and many protostomes have independently experienced multiple massive losses of CBP genes that might be due to the geologic events during the Ediacaran period, such as the appearance of an exogenous sterol supply and the frequent perturbation of ocean oxygenation. Meanwhile, the indispensable utilization processes of cholesterol potentially strengthened the maintenance of the complete set of CBP genes in vertebrates. These results strengthen both biotic and abiotic roles in the macroevolution of a biosynthesis pathway in animals.</p>
PIN1 isomerase promotes the initiation and progression of bladder cancer through SREBP2-mediated cholesterol biosynthesis pathway
GEO Series GSE262761. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Cholesterol biosynthesis pathway as a novel mechanism of resistance to estrogen deprivation in estrogen receptor positive breast cancer
GEO Series GSE75971. Homo sapiens. 54 samples. Type: Expression profiling by array.
Cystatin from the helminth Ascaris lumbricoides (Al-CPI) upregulates mevalonate and cholesterol biosynthesis pathways and immunomodulatory genes in human monocyte-derived dendritic cells (moDC)
GEO Series GSE250463. Homo sapiens. 42 samples. Type: Expression profiling by high throughput sequencing.
NFATc1 and NFATc2 regulate glucocorticoid resistance in pediatric T-cell acute lymphoblastic leukemia through modulation of cholesterol biosynthesis and the WNT/β-catenin pathway
GEO Series GSE253998. Homo sapiens. 16 samples. Type: Expression profiling by array.
Podocalyxin-Like Protein 1 Regulates Pluripotency through the Cholesterol Biosynthesis Pathway
GEO Series GSE213618. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
NFATc1 and NFATc2 regulate glucocorticoid resistance in pediatric T-cell acute lymphoblastic leukemia through modulation of cholesterol biosynthesis and the WNT/β-catenin pathway
GEO Series GSE253996. Homo sapiens. 14 samples. Type: Expression profiling by array.
NFATc1 and NFATc2 regulate glucocorticoid resistance in pediatric T-cell acute lymphoblastic leukemia through modulation of cholesterol biosynthesis and the WNT/β-catenin pathway
GEO Series GSE253999. Homo sapiens. 12 samples. Type: Expression profiling by array.
NFATc1 and NFATc2 control glucocorticoid resistance in pediatric T-cell acute lymphoblastic leukemia by regulating cholesterol biosynthesis and WNT/ꞵ-catenin pathway
GEO Series GSE254001. Homo sapiens. 42 samples. Type: Expression profiling by array.
Podocalyxin-Like Protein 1 Regulates Extended and Primed Pluripotency through the Cholesterol Biosynthesis Pathway
GEO Series GSE189014. Homo sapiens; Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
A Pancreas Organoids-based Screen Identifies a Specific KRAS Mutation Inhibitor that Attenuating Cholesterol Biosynthesis Pathway in Pancreatic Cancer
GEO Series GSE207352. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.