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158 results for “coactivation”
Functional Coactivation Map of the Human Brain - Figures
<p>These are author versions of the figures of the article "Functional coactivation map of the human brain", <a href="https://doi.org/10.1093/cercor/bhn014">https://doi.org/10.1093/cercor/bhn014</a></p> <p><strong>Fig. 1 (fig1v2.tif)</strong> Characterization of the experiments used in the coactivation map. Distribution of the different cognitive domains represented by the experiments after the BrainMap classification (A). Histogram of the number of locations per experiment (B). Experiments reported on average 8 locations, and a decreasing number of experiments reported large numbers of locations.</p> <p><strong>Fig. 2 (fig2v2.tif)</strong> Reproducibility of the coactivation map. Pairs of partial coactivation maps computed from disjoint random subsets of the total database of experiments were progressively more similar as the number of experiments increased. The plot shows the distribution of the correlation coefficient for 20 pairs of partial coactivation maps computed from independent sets of 500, 700, 900, 1100, 1300, 1500, and 1700 experiments.</p> <p><strong>Fig. 3 (fig-symm.tif)</strong> Symmetric interhemispheric coactivations. Coactivations of regions in the left hemisphere included most of the time the symmetric region in the right hemisphere, and vice versa. The figure shows 3-dimensional reconstructions (A, B) and stereotaxic slices of 4 networks corresponding to 4 seed-voxels in the axial plane z = 28 (C), and 4 networks in the coronal plane y = −6 (D). The network clusters are isosurfaces for P = 0.01, and the location of the seed-voxels is indicated by white squares in the stereotaxic slices.</p> <p><strong>Fig. 4 (fig-ipsl.tif)</strong> Fronto-parietal “attention” network. Three-dimensional reconstruction and axial (z = 48) and para-sagittal (x = 30) stereotaxic slices of the network recovered with a seed-voxel at the left intraparietal sulcus (IPS, x = −26, y = −58, z = 48). It includes the supplementary motor area (SMA) and preSMA, left and right anterior insula (aIns), frontal eye fields (FEF), dorsolateral prefrontal cortex (DLPFC), inferior precentral sulcus (iPCS), ventral occipital cortex (vOC), inferior parietal lobule (iPL), and the ventral IPS (vIPS). The network clusters are isosurfaces for P = 0.01, and the location of the seed-voxel is indicated in the axial slice by a white square.</p> <p><strong>Fig. 5 (fig-acc.tif) </strong>Cingulo-parietal “resting state” network. Three-dimensional reconstructions and sagittal stereotaxic slice (x = −2) of the network recovered with a seed-voxel at the anterior cingulate cortex (aCC, x = −2, y = 46, z = −4). It includes the posterior cingulate cortex (pCC), nucleus accumbens (NA), lateral parietal cortex (LPC), inferior temporal cortex (iTC), and the superior frontal cortex (SFC). The network clusters are isosurfaces for P = 0.01 (strong red), and P = 0.5 (in transparency). The location of the seed-voxel is indicated by a white square in the sagittal slice.</p> <p><strong>Fig. 6 (fig-motor.tif)</strong> Cortico-diencephalo-cerebellar “motor” network. Three-dimensional reconstructions and coronal (y = −26) and para-sagittal (x = −34) stereotaxic slices of the network recovered with a seed-voxel at the dorsal part of the left central sulcus (CS, x = −34, y = −26, z = 60). The network includes the right central sulcus, caudal cingulate motor area (CMA), ipsilateral putamen (Pu), thalamus (Th), and left cerebellum (Cb-L), and the contralateral anterior lobe of the cerebellum (aCb). The network clusters are isosurfaces for P = 0.01, and the seed-voxel is indicated by white squares in the coronal and sagittal slices.</p>
Stroke data from: Robust dynamic brain coactivation states estimated in individuals
<p><span>A confluence of evidence indicates that brain functional connectivity (FC) is not static but rather dynamic. </span><span>Capturing transient </span><span>network interactions in the individual brain requires a technology that offers sufficient within-subject reliability. Here, we introduce an </span><span>individualized network-based dynamics analysis technique and demonstrate that it is reliable in detecting subject-specific brain states during both resting state and a cognitively challenging language task.</span> <span>Moreover, we evaluated the extent to which brain states showed hemispheric asymmetries and how various phenotypic factors such as handedness and gender might influence network dynamics. </span><span>W</span><span>e discovered a right-lateralized brain state that occurred more frequently in men than in women, and more frequently in right-handed versus left-handed individuals. Lastly, we demonstrated longitudinal brain state changes in 42 patients with subcortical stroke over 6 months. Taken together, this approach could quantify subject-specific dynamic brain states and has potential for use in both basic and clinical neuroscience research.</span></p>
Stroke data from: Robust dynamic brain coactivation states estimated in individuals
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Data from: Coactivator condensation drives cardiovascular cell lineage specification
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Effect of Muscle Coactivation Strengthening for Rotator Cuff Tendinopathy
ClinicalTrials.gov study NCT02837848. IPD Sharing: UNDECIDED. Countries: 1. Publications: 12.
Perineal Massage in Pregnancy to Reduce the Levator Ani Coactivation
ClinicalTrials.gov study NCT06296134. IPD Sharing: YES. Countries: 1. Publications: 7.
Predominantly linear summation of metabotropic postsynaptic potentials follows coactivation of neurogliaform interneurons
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Data from: Perturbing the cellular cevels of steroid receptor coactivator-2 impairs murine endometrial function
As pleiotropic coregulators, members of the p160/steroid receptor coactivator (SRC) family control a broad spectrum of transcriptional responses that underpin a diverse array of physiological and pathophysiological processes. Because of their potent coregulator properties, strict controls on SRC expression levels are required to maintain normal tissue functionality. Accordingly, an unwarranted increase in the cellular levels of SRC members has been causally linked to the initiation and/or progression of a number of clinical disorders. Although knockout mouse models have underscored the critical non-redundant roles for each SRC member in vivo, there are surprisingly few mouse models that have been engineered to overexpress SRCs. This deficiency is significant since SRC involvement in many of these disorders is based on unscheduled increases in the levels (rather than the absence) of SRC expression. To address this deficiency, we used recent mouse technology that allows for the targeted expression of human SRC-2 in cells which express the progesterone receptor. Through cre-loxP recombination driven by the endogenous progesterone receptor promoter, a marked elevation in expression levels of human SRC-2 was achieved in endometrial cells that are positive for the progesterone receptor. As a result of this increase in coregulator expression, female mice are severely subfertile due to a dysfunctional uterus, which exhibits a hypersensitivity to estrogen exposure. Our findings strongly support the proposal from clinical observations that increased levels of SRC-2 are causal for a number of endometrial disorders which compromise fertility. Future studies will use this mouse model to decipher the molecular mechanisms that underpin the endometrial defect. We believe such mechanistic insight may provide new molecular descriptors for diagnosis, prognosis, and/or therapy in the clinical management of female infertility.
A Randomised Controlled Trial to Evaluate the Impact of Complement Theory's Live CoActive Exercise Coaching and Personalized Digital Application on Cancer Survivors' Quality of Life
ClinicalTrials.gov study NCT06397651. IPD Sharing: YES. Countries: 1. Publications: 0.
Data from: Perturbing the cellular cevels of steroid receptor coactivator-2 impairs murine endometrial function
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The phenylalanine-and-glycine repeats of NUP98 oncofusions form condensates that selectively partition transcriptional coactivators
GEO Series GSE255868. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Transcription factor EHF interacting with transcription coactivator AJUBA (JUB) aggravates malignancy of gastroesophageal adenocarcinoma [ATAC-seq]
GEO Series GSE207555. Homo sapiens. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability
GEO Series GSE150303. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
The transcriptional coactivator Cbp regulates self-renewal and differentiation in adult hematopoietic stem cells
GEO Series GSE25274. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array.
SUPT3H-less SAGA coactivator can assemble and function without significantly perturbing RNA polymerase II transcription in mammalian cells
GEO Series GSE175901. Homo sapiens; Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage
GEO Series GSE186614. Homo sapiens; Mus musculus. 79 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Endogenous interaction profiling identifies DDX5 as an oncogenic coactivator of transcription factor Fra-1 [ChIP-seq]
GEO Series GSE112961. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Ablation of coactivator Med1 regulates bulge keratinocyte stem cells and accelerates epidermal regeneration after injury [skin wound]
GEO Series GSE50670. Mus musculus. 4 samples. Type: Expression profiling by array.
A TAF4 coactivator function for E proteins that involves enhanced TFIID binding
GEO Series GSE46807. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
The Leukemia-associated Mllt10/Af10- Dot1l, dedicated b-catenin coactivators essential for intestinal homeostasis
GEO Series GSE21367. Homo sapiens. 12 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.