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60 results for “collagen type I”
Early Clinical Outcomes of High-Purity Type I Collagen as a Biologic Reinforcement in Selected Hernia Repair Scenarios
ClinicalTrials.gov study NCT07360691. IPD Sharing: YES. Countries: 1. Publications: 7.
Evaluation of High-Purity Type I Collagen Biologic Wrap to Improve Function After Extensor Tendon Repair of the Hand
ClinicalTrials.gov study NCT07335653. IPD Sharing: YES. Countries: 1. Publications: 7.
HT1080WT cells embedded in 3D collagen type I matrices - manual annotations for cell instance segmentation and tracking
<p>Human fibrosarcoma HT1080WT (ATCC) cells at low cell densities embedded in 3D collagen type I matrices [1]. The time-lapse videos were recorded every 2 minutes for 16.7 hours and covered a field of view of 1002 pixels × 1004 pixels with a pixel size of 0.802 μm/pixel The videos were pre-processed to correct frame-to-frame drift artifacts, resulting in a final size of 983 pixels × 985 pixels pixels.</p> <p><em>Hasini Jayatilaka, Anjil Giri, Michelle Karl, Ivie Aifuwa, Nicholaus J Trenton, Jude M Phillip, Shyam Khatau, and Denis Wirtz. EB1 and cytoplasmic dynein mediate protrusion dynamics for efficient 3-dimensional cell migration. FASEB J., 32(3):1207–1221, 2018. ISSN 0892-6638. doi: 10.1096/fj.201700444RR.</em></p> <p>Further information about how to use this data is given in <a href="http://github.com/esgomezm/microscopy-dl-suite-tf">https://github.com/esgomezm/microscopy-dl-suite-tf</a></p> <p><strong>This dataset is provided together with the following preprint and if you use it, we would like to kindly ask you to cite it properly:</strong></p> <p><a href="https://arxiv.org/abs/2112.08817">Estibaliz Gómez-de-Mariscal, Hasini Jayatilaka, Özgün Çiçek, Thomas Brox, Denis Wirtz, Arrate Muñoz-Barrutia, *Search for temporal cell segmentation robustness in phase-contrast microscopy videos*, arXiv 2021 (arXiv:2112.08817)</a></p>
Supplementary Information for Phylogenetic analyses of ray-finned fishes (Actinopterygii) using collagen type I protein sequences
<p>Ray-finned fishes (Actinopterygii) are the largest and most diverse group of vertebrates, comprising over half of all living vertebrate species. Phylogenetic relationships between ray-finned fishes have historically pivoted on the study of morphology, which has notoriously failed to resolve higher-order relationships, such as within the percomorphs. More recently, comprehensive genomic analyses have provided further resolution of actinopterygian phylogeny, including higher-order relationships. Such analyses are rightfully regarded as the 'gold standard' for phylogenetics. However, DNA retrieval requires modern or well-preserved tissue and is less likely to be preserved in archaeological or fossil specimens. In contrast some proteins, such as collagen, are phylogenetically informative and can survive into deep time. Here, we test the utility of collagen type I amino acid sequences for phylogenetic estimation of ray-finned fishes. We estimate topology using Bayesian approaches and compare the congruence of our estimated trees with published genomic phylogenies. Furthermore, we apply a Bayesian molecular clock approach and compare estimated divergence dates with previously published genomic clock analyses. Our collagen-derived trees exhibit 77% of node positions as congruent with recent genomic-derived trees, with the majority of discrepancies occurring in higher-order node positions, almost exclusively within the Percomorpha. Our molecular clock trees present divergence times that are fairly comparable with genomic-based phylogenetic analyses. We estimate the mean node age of Actinopteri at ~293 million years (Ma), the base of Teleostei at ~211 Ma and the radiation of percomorphs beginning at ~141 Ma (~350 Ma, ~250–283 Ma and ~120–133 Ma in genomic trees, respectively). Finally, we show that the average rate of collagen (I) sequence evolution is 0.9 amino acid substitutions for every million years of divergence, with the α3 (I) sequence evolving the fastest, followed by the α2 (I) chain. This is the quickest rate known for any vertebrate group. We demonstrate that phylogenetic analyses using collagen type I amino acid sequences generate tangible signals for actinopterygians that are highly congruent with recent genomic-level studies. However, there is limited congruence within percomorphs, perhaps due to clade-specific functional constraints acting upon collagen sequences. Our results provide important insights for future phylogenetic analyses incorporating extinct actinopterygian species via collagen (I) sequencing.</p>
Raw, unprocessed SEM data images for: Figure 1: Scanning electron microscope images of "type-1 bone collagen" demineralized bone matrix fibrils
<p>Raw, unprocessed SEM data images for Figure 1 of the manuscript: Scanning electron microscope images of "type-1 bone collagen" demineralized bone matrix fibrils. (A) Fibrils from the <em>B</em>. <em>taurus</em> extant long bone control. Prominent banding (~67nm) is present that is characteristic of type-1 collagen protein fibrils (Boatman et al., 2019; Gottardi et al., 2016; Lin et al., 1993; Rabotyagova et al., 2008; Tzaphlidou, 2005). (B) Permafrost YG 610.2397 <em>M</em>. <em>primigenius</em> demineralized bone matrix fibrils. An ~67nm banding pattern on the fibrils is also observed but is somewhat less distinct in comparison to that of the extant <em>B</em>. <em>taurus</em> specimen. (C) Observed fibril structures in the temperate MOR 91.72 <em>M</em>. <em>columbi</em> specimen. Fibril banding is generally absent, suggesting the original chemical state of the type-1 collagen fibrils/sequences is substantially altered.</p>
High-Purity Type I Collagen Nerve Wrapping in Peripheral Nerve Procedures: A Prospective Registry
ClinicalTrials.gov study NCT07360730. IPD Sharing: YES. Countries: 1. Publications: 10.
Multicentric RCT Comparing High Purity Type I Collagen-Skin Substitute vs dHACM in Treatment of Diabetic Foot Ulcers
ClinicalTrials.gov study NCT07046403. IPD Sharing: NO. Countries: 1. Publications: 8.
Treatment of Full-Thickness Wounds: NPWT Combined With Type-I Collagen Based Advanced Skin Substitute Versus NPWT Alone
ClinicalTrials.gov study NCT06873867. IPD Sharing: NO. Countries: 1. Publications: 4.
High-Purity Type I Collagen Augmentation in Meniscal Repair
ClinicalTrials.gov study NCT07352410. IPD Sharing: NO. Countries: 1. Publications: 8.
A RCT Evaluating Efficacy of Type-I Collagen Skin Substitute vs. Human Amnion Membrane in Treatment of Venous Leg Ulcers
ClinicalTrials.gov study NCT06831760. IPD Sharing: NO. Countries: 1. Publications: 3.
SurgiPerito Trial: High-Purity Type-I Collagen for Peritoneal Reconstruction After Cytoreductive Surgery
ClinicalTrials.gov study NCT07241091. IPD Sharing: YES. Countries: 1. Publications: 5.
High Purity Type I Collagen Based Skin Substitute Vs Dehydrated Human Amnion/Chorion Membrane in Treatment of DFUs
ClinicalTrials.gov study NCT06470087. IPD Sharing: NO. Countries: 1. Publications: 5.
Raw, unprocessed SEM data images for: Figure 1: Scanning electron microscope images of “type-1 bone collagen” demineralized bone matrix fibrils
Open the record for dataset details and reuse information.
Supplementary Information for Phylogenetic analyses of ray-finned fishes (Actinopterygii) using collagen type I protein sequences
Open the record for dataset details and reuse information.
NAtive Collagen Type II In Healthy VoluntEers With Joint Discomfort
ClinicalTrials.gov study NCT05282992. IPD Sharing: NO. Countries: 1. Publications: 0.
Oral Type I Collagen for Relieving Scleroderma
ClinicalTrials.gov study NCT00005675. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Hydrolyzed Collagen and Undenatured Collagen Type II in OA Knee
ClinicalTrials.gov study NCT06229951. IPD Sharing: YES. Countries: 1. Publications: 1.
A Natural History Study in Children With a Type II Collagen Disorder With Short Stature
ClinicalTrials.gov study NCT05408715. IPD Sharing: UNDECIDED. Countries: 2. Publications: 4.
Immediate Implant Placement in Type ii Socket by Vestibular Socket Therapy Using Collagen Membrane
ClinicalTrials.gov study NCT07337837. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Intramuscular Effect of Polymerized Type I Collagen on the Cytokine Storm in COVID-19 Patients
ClinicalTrials.gov study NCT04517162. IPD Sharing: NO. Countries: 1. Publications: 31.
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OpenNeuro
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