Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
86
datasets available to search
ShareScore release 0.9.0
Dataset results
86 results for “colonic stem cell”
A Single-cell Perturbation Landscape of Colonic Stem Cell Polarisation
<p>Cancer cells are regulated by oncogenic mutations and microenvironmental signals, yet these processes are often studied separately. To functionally map how cell-intrinsic and cell-extrinsic cues co-regulate cell-fate in colorectal cancer (CRC), we performed a systematic single-cell analysis of 1,107 colonic organoid cultures regulated by 1) CRC oncogenic mutations, 2) microenvironmental fibroblasts and macrophages, 3) stromal ligands, and 4) signalling inhibitors. Multiplexed single-cell analysis revealed a stepwise epithelial differentiation landscape dictated by combinations of oncogenes and stromal ligands, spanning from fibroblast-induced Clusterin (CLU)<sup>+</sup> revival colonic stem cells (revCSC) to oncogene-driven LRIG1<sup>+</sup> hyper-proliferative CSC (proCSC). The transition from revCSC to proCSC is regulated by decreasing WNT3A and TGF-β-driven YAP signalling and increasing KRAS<sup>G12D</sup> or stromal EGF/Epiregulin-activated MAPK/PI3K flux. We find APC-loss and KRAS<sup>G12D</sup> collaboratively limit access to revCSC and disrupt stromal-epithelial communication -- trapping epithelia in the proCSC fate. These results reveal that oncogenic mutations dominate homeostatic differentiation by obstructing cell-extrinsic regulation of cell-fate plasticity.</p>
Invasiveness and Chemoresistance of Cancer Stem Cells in Colon Cancer
ClinicalTrials.gov study NCT01577511. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Changes in Stem Cells of the Colon in Response to Increased Risk of Colorectal Cancer
ClinicalTrials.gov study NCT01075893. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Establishment of an ulcerative colitis model using colon organoids derived from human induced pluripotent stem cells
GEO Series GSE244981. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colon [scrna-seq]
GEO Series GSE240358. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome profiles of colonic stem cells of WT and AHR deficient mice treated with either DMSO or high affinity AHR ligand, FICZ for 4 hours
GEO Series GSE179481. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colon
GEO Series GSE240363. Homo sapiens. 26 samples. Type: Expression profiling by high throughput sequencing.
Bulk RNA-seq of colonic epithelial stem cell-derived organoids from healthy epithelial HO-1 knockout and control mice exposed to hemin vs vehicle
GEO Series GSE312912. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Colon Cancer Patient-Derived Spheroids and their Stem Cell-Intrinsic mRNA Expression Yield Novel Prognostic Signatures
GEO Series GSE216724. Homo sapiens. 64 samples. Type: Expression profiling by array.
Cell cycle dependent variation of a CD133 epitope in human embryonic stem cell, colon cancer and melanoma cell lines.
GEO Series GSE11757. Homo sapiens. 8 samples. Type: Expression profiling by array.
Cell lines iPSC CRL1831 (induced pluripotent stem cells) and CSC DLD1 (cancer stem-like cells) derived from normal colon CRL1831 and colorectal cancer DLD-1 cells in 3D cell culture conditions and su
GEO Series GSE93228. Homo sapiens. 11 samples. Type: Expression profiling by array.
Nox1 and Npy1r mark regional colon stem cell populations that serve as cancer origins in vivo [RNA_seq]
GEO Series GSE303295. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome profiles of colonic stem cells of WT and AhR deficient mice
GEO Series GSE133092. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Stem cell functionality is microenvironmentally defined during tumor expansion and therapy response in colon cancer
GEO Series GSE95499. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Reg4+ Deep Crypt Secretory cells function as epithelial niche for Lgr5+ stem cells in colon
GEO Series GSE63256. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Small molecule inhibition of MEK activates Wnt signalling and leads to reprogramming of colon cancer stem cells [Illumina]
GEO Series GSE114059. Homo sapiens. 24 samples. Type: Expression profiling by array.
Identification of A Drug Blocking SARS-CoV-2 Infection using Human Pluripotent Stem Cell-derived Colon Organoids
GEO Series GSE147975. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Identification of differentially expressed small RNAs of colon cancer stem cells.
GEO Series GSE43793. Homo sapiens. 4 samples. Type: Non-coding RNA profiling by high throughput sequencing.
R-spondin 3 regulates stem cell plasticity and recovery of damaged colon epithelium
GEO Series GSE115752. Mus musculus. 4 samples. Type: Expression profiling by array.
miR-4711-5p regulates the cancer stemness and cell cycle progression through direct binding to KLF5, MDM2 and TFDP1 in colon cancer cells
GEO Series GSE134442. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.