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88 results for “colorectal cancer liver metastasis”
Hepatocellular carcinoma (HCC) Tumor microenvironment is more suppressive than colorectal cancer liver metastasis (CRLM) Tumor microenvironment.
<p><strong>Background and purpose:</strong> While HCC is an inflammation-associated cancer, CRLM develop on permissive healthy liver microenvironment. To evaluate the immune aspects of these two different environments, peripheral blood-(PB), peritumoral-(PT) and tumoral tissues-(TT) from HCC and CRLM patients were evaluated.</p> <p><strong>Methods:</strong> 40 HCC and 34 CRLM were enrolled and freshly TT, PT and PB were collected at the surgery. PB-, PT- and TT-derived CD4<sup>+</sup>CD25<sup>+ </sup>Tregs, M/PMN-MDSC and PB-derived CD4<sup>+</sup>CD25<sup>− </sup>Teffector cells (Teffs) were isolated and characterized. Tregs function was also evaluated in the presence of the CXCR4 inhibitor, Peptide-R29, AMD3100 or anti-PD1. RNA was extracted from PB/PT/TT-tissues and tested for FOXP3, CXCL12, CXCR4, CCL5, IL-15, CXCL5, Arg-1, N-cad, Vim, CXCL8, TGFβ and VEGF-A expression.</p> <p><strong>Results:</strong> In HCC/CRLM-PB higher number of functional Tregs, CD4<sup>+</sup>CD25<sup>hi</sup>FOXP3<sup>+</sup> were detected, although PB-HCC Tregs exert a more suppressive function as compared to CRLM-Tregs. In HCC/CRLM-TT Tregs were highly represented with Activated/ENTPD-1<sup>+</sup>Tregs prevalent in HCC. As compared to CRLM, HCC overexpressed CXCR4 and N-cadherin/Vimentin in a contest rich of arginase and CCL5. Monocytic-MDSCs were highly represented in HCC/CRLM while high Polymorphonuclear-MDSCs were detected only in HCC. Interestingly, CXCR4-PB-Tregs function was impaired in HCC/CRLM by the CXCR4 inhibitor R29.</p> <p><strong>Conclusion:</strong> In HCC and CRLM, peripheral blood, peritumoral and tumoral tissues-Tregs are highly represented and functional. Nevertheless, HCC display a more immunosuppressive TME due to Tregs, MDSCs, intrinsic tumor features (CXCR4, CCL5, arginase) and the contest in which it develops. As CXCR4 is overexpressed in HCC/CRLM tumor/TME cells, CXCR4 inhibitors may be considered for double hits therapy in liver cancer patients.</p>
Study of BO-112 With Pembrolizumab for Colorectal or Gastric/GEJ Cancer With Liver Metastasis
ClinicalTrials.gov study NCT04508140. IPD Sharing: NO. Countries: 3. Publications: 1.
Liver regeneration-associated hepatocellular YAP1 activation prevents colorectal cancer liver metastasis through glutamine competition
Open the record for dataset details and reuse information.
Trial of Preoperative Hepatic and Regional Arterial Chemotherapy (PHRAC) to Prevent Postoperative Liver Metastasis of Colorectal Cancer
ClinicalTrials.gov study NCT00643877. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Surgery Outcome Treated by Neo-adjuvant Combination of Oxaliplatin, Irinotecan, Folinic Acid and Fluorouracil (FOLFOXIRI) Regimen in Synchronous Liver Limited Metastasis Colorectal Cancer
ClinicalTrials.gov study NCT05362825. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Adjuvant Xeloda Plus Eloxatin +/- Avastin After Radical Resection of Liver Metastasis of Colorectal Cancer
ClinicalTrials.gov study NCT00394992. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Exosome-derived Extrahepatic Metastasis Detection By Liquid Biopsy In Colorectal Cancer Liver Metastases
ClinicalTrials.gov study NCT07224724. IPD Sharing: NO. Countries: 1. Publications: 8.
Single-cell RNA-seq dataset and code for human colorectal cancer liver metastasis study
Open the record for dataset details and reuse information.
TACE Plus HAIC Combined With Regorafenib for Liver Metastasis of Colorectal Cancer Refractory to Standard Treatment Regimens
ClinicalTrials.gov study NCT06071052. IPD Sharing: NO. Countries: 1. Publications: 0.
A Study of Single Fraction Stereotactic Body Radiation Therapy (SBRT) Guided by Magnetic Resonance Imaging (MRI) in People With Liver Metastasis From Colorectal Cancer
ClinicalTrials.gov study NCT06130280. IPD Sharing: YES. Countries: 1. Publications: 0.
Cxcr3 promotes protection from colorectal cancer liver metastasis by driving NK infiltration and plasticity
GEO Series GSE266900. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Tyk2 controls immunosurveillance of colorectal cancer liver metastasis
GEO Series GSE299638. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Tumor-derived exosomal miR-181a-5p activates hepatic stellate cells to promote liver metastasis of colorectal cancer
GEO Series GSE141997. Homo sapiens. 12 samples. Type: Non-coding RNA profiling by array.
Th17 cells secrete TWEAK to trigger epithelial-mesenchymal transition and promote colorectal cancer liver metastasis (RNA-seq)
GEO Series GSE255163. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing.
Development of gene expression profiles for tumour derived endothelium vs. matched healthy tissues (in renal cell carcinoma, colorectal cancer and colorectal metastasis to the liver)
GEO Series GSE77199. Homo sapiens. 24 samples. Type: Expression profiling by array.
Genome-wide analysis of long noncoding RNA (lncRNA) expression in colorectal cancer tissues from patients with liver metastasis
GEO Series GSE75050. Homo sapiens. 12 samples. Type: Non-coding RNA profiling by array.
Single-cell analyses reveal phenotypic linkage between colorectal cancer and liver metastasis
GEO Series GSE164522. Homo sapiens. 17 samples. Type: Expression profiling by high throughput sequencing.
MicroRNA expression signatures of CD14-CD45-EpCAM+ cells in human bone marrow for colorectal cancer liver metastasis
GEO Series GSE51716. Homo sapiens. 19 samples. Type: Non-coding RNA profiling by array.
Sequential treatment with activin and hepatocyte growth factor(HGF) induces FOXM1 to promote colorectal cancer liver metastasis
GEO Series GSE205986. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer (ChIP-Seq)
GEO Series GSE106921. Homo sapiens. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.