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22 results for “compensatory responses”
Off-target integron activity leads to rapid plasmid compensatory evolution in response to antibiotic selection pressure
Integrons are mobile genetic elements that have played an important role in the dissemination of antibiotic resistance. As shown previously (Souque et al, 2021), the integron can generate under stress combinatorial variation in resistance cassette expression by cassette re-shuffling, accelerating the evolution of resistance. However, the flexibility of the integron integrase site recognition motif hints at potential off-target effects of the integrase on the rest of the genome that may have important evolutionary consequences. Here we test this hypothesis by selecting for increased piperacillin resistance populations of <em>P.aeruginosa</em> with a mobile integron containing a hard-to-mobilise beta-lactamase cassette to minimize the potential for adaptive cassette re-shuffling. We found that integron activity can both decrease overall survival rate but also improve the fitness of the surviving populations. Off-target inversions mediated by the integron accelerated plasmid adaptation by disrupting costly conjugative genes otherwise mutated in control populations lacking a functional integrase. Plasmids containing integron-mediated inversions were associated with lower plasmid costs and higher stability than plasmids carrying mutations, albeit at a cost of reduced conjugative ability. These findings highlight the potential for integrons to create structural variation that can drive bacterial evolution, and they provide an interesting example showing how antibiotic pressure can drive the loss of conjugative genes.
Resources do not limit compensatory response of a tallgrass prairie plant community to the loss of a dominant species
<p>The effect of species loss on ecosystem productivity is determined by both the functional contribution of the species lost, and the response of the remaining species in the community. According to the mass-ratio hypothesis, the loss of a dominant plant species, which has a larger proportionate contribution to productivity, is expected to exert an overwhelming effect on this important ecosystem function. However, via competitive release, loss of a dominant species can provide the opportunity for other plant species to establish, thrive and become abundant in the community, potentially compensating for the function lost. Furthermore, if resource limitation is removed, then compensatory response of function to the loss of a dominant species should be greater and more rapid than if resources are more limiting.</p> <p>To evaluate how resources may limit compensation of aboveground productivity to the loss of a dominant plant species, we experimentally removed the C<sub>4</sub> perennial tallgrass, <em>Andropogon gerardii</em>, from intact plant communities. We added water for four years, as well as nitrogen in the fourth year, to test the effect of resource limitation on the compensatory response.</p> <p>Overall, aboveground biomass production increased in the remaining community with both water and nitrogen addition. However, this increase in biomass production was not sufficient to fully compensate for the loss of A. gerardii, indicating water and nitrogen were not limiting short-term compensation in this community.</p> <p>Following the removal of the dominant species, there was a reordering of species abundances in the community, rather than changes in species richness. The C<sub>4</sub> grass <em>Bouteloua curtipendula</em> was the most responsive species, increasing by 57.9% in abundance with water addition and 91.0% with both water and nitrogen addition. Despite this dramatic increase in abundance, its short stature and lower per capita biomass production prevented this species from compensating for the loss of <em>A. gerardii</em>.</p> <p>Our results suggest that short-term compensation after the loss of a dominant plant species can be hastened by increased resource availability, but ultimately full compensation appears to be limited by the presence and abundance of species in the remaining community that possess traits that allow them compensate for the species lost.</p>
Resource limitation of compensatory responses in ecosystem processes after biodiversity loss
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Off-target integron activity leads to rapid plasmid compensatory evolution in response to antibiotic selection pressure
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Resources do not limit compensatory response of a tallgrass prairie plant community to the loss of a dominant species
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Compensatory responses differ between parental tasks in a songbird species - Dataset
<p>Dataset relative to manuscript number A22-00211R2</p>
Data from: Compensatory life history responses of a mesopredator may undermine carnivore management efforts
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Data from: Population divergence in compensatory growth responses and their costs in sticklebacks
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Obese Insulin Resistant Humans with Compensatory Hyperinsulinemia Dissociate Lipolysis from Glycemia as Possible Adaptive Response to Fatness
GEO Series GSE141432. Homo sapiens. 25 samples. Type: Expression profiling by high throughput sequencing.
Progressive ER stress over time due to human insulin gene mutation contributes to pancreatic β-cell dysfunction, islet inflammation and compensatory responses
GEO Series GSE141319. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
MiRNA networks mediate a compensatory response in heart failure induced cognitive impairment [smallRNA-Seq]
GEO Series GSE288826. Mus musculus. 40 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Huntington disease mice exhibit a TCF7L2-responsive suppression of both homeostatic and compensatory remyelination
GEO Series GSE181370. Mus musculus. 46 samples. Type: Expression profiling by high throughput sequencing.
MiRNA networks mediate a compensatory response in heart failure induced cognitive impairment [RNA-Seq]
GEO Series GSE288827. Mus musculus. 26 samples. Type: Expression profiling by high throughput sequencing.
Divergent Compensatory Responses to High Fat Diet Between C57BL6/J and C57BLKs/J Inbred Mouse Strains
GEO Series GSE51055. Mus musculus. 24 samples. Type: Expression profiling by array.
Improving Anticipatory and Compensatory Postural Responses to Avoid Falls After TBI
ClinicalTrials.gov study NCT05268484. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Compensatory Behavior of E-cig Users in Response to Reduced Nicotine E-liquids
ClinicalTrials.gov study NCT06602492. IPD Sharing: NO. Countries: 1. Publications: 0.
Pharmacologic Activation of a Compensatory Integrated Stress Response Kinase Promotes Adaptive Mitochondrial Remodeling in Perk-deficient Cells
GEO Series GSE227134. Mus musculus. 36 samples. Type: Expression profiling by high throughput sequencing.
The unfolded protein response supports cellular robustness as a broad-spectrum compensatory pathway.
GEO Series GSE33844. Saccharomyces cerevisiae. 15 samples. Type: Expression profiling by array.
Chronic cardiac contractile dysfunction without hypertrophy does not provoke a compensatory transcriptional response
GEO Series GSE73909. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Age-dependent heat shock hormesis to HSF-1 deficiency suggests a compensatory mechanism mediated by the unfolded protein response and innate immunity in young Caenorhabditis elegans
GEO Series GSE241011. Caenorhabditis elegans. 12 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
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