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13
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ShareScore release 0.9.0
Dataset results
13 results for “context-dependent signal”
Stimulating Wnt signaling reveals context-dependent genetic effects on gene regulation in primary human neural progenitors
<p>Summary statistics for chromatin accessibility and gene expression quantitative trait loci (ca/eQTLs) from Matoba, N., Le, B.D., Valone, J.M. <em>et al.</em> Stimulating Wnt signaling reveals context-dependent genetic effects on gene regulation in primary human neural progenitors. <em>Nat Neurosci</em> (2024). https://doi.org/10.1038/s41593-024-01773-6</p>
Data from: Context-dependent signaling of coincident auditory and visual events in primary visual cortex
Detecting rapid, coincident changes across sensory modalities is essential for recognition of sudden threats or events. Using two-photon calcium imaging in identified cell types in awake, head-fixed mice, we show that, among the basic features of a sound envelope, loud sound onsets are a dominant feature coded by the auditory cortex neurons projecting to primary visual cortex (V1). In V1, a small number of layer 1 interneurons gates this cross-modal information flow in a context-dependent manner. In dark conditions, auditory cortex inputs lead to suppression of the V1 population. However, when sound input coincides with a visual stimulus, visual responses are boosted in V1, most strongly after loud sound onsets. Thus, a dynamic, asymmetric circuit connecting AC and V1 contributes to the encoding of visual events that are coincident with sounds.
Data from: Context-dependent alarm signalling in an insect
Animals often respond to danger by raising alarm to inform others. Alarm signals come in many different forms, such as visual or mechanical display, sound or odour. Some animals produce vocal alarm signals that vary with the level of danger. For chemical alarm signals, virtually nothing is known about such context-dependent signalling due to a general notion that alarm pheromones have fixed compositions. Here, we show that larvae of the Western Flower Thrips (Frankliniella occidentalis) produce an alarm pheromone whose composition varies with the level of danger they face: the presence of a relatively harmless predator or a very dangerous predator, that is either actually attacking or not. The frequency of alarm pheromone excretion increases with the level of danger. Moreover, the composition of excreted alarm pheromone varies in the relationship between total and relative amount of the putative two components, decyl acetate (DAc) and dodecyl acetate (DDAc). When pheromone is excreted with a predator present but not attacking, the percentage DDAc increases with the total amount of pheromone. When a predator does attack, however, the relationship between percentage DDAc and total amount of pheromone is reversed. Taken together, the alarm signal of thrips larvae appears to be context dependent, which to our knowledge is the first report of context-dependent composition of an alarm pheromone.
Data from: Context-dependent signaling of coincident auditory and visual events in primary visual cortex
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Data from: Context-dependent alarm signalling in an insect
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Context-dependent Regulation of Notch Signaling in Glial Development and Tumorigenesis
GEO Series GSE240224. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Ets1 confers context-dependent activation of Notch signaling in T-cell leukemia [RNA-Seq]
GEO Series GSE138659. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity
GEO Series GSE220959. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Context-dependent Regulation of Notch Signaling in Glial Development and Tumorigenesis [scRNA-seq]
GEO Series GSE240222. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
Context-dependent Regulation of Notch Signaling in Glial Development and Tumorigenesis [Bulk RNA-seq]
GEO Series GSE240223. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
Ets1 confers context-dependent activation of Notch signaling in T-cell leukemia [ChIP-Seq]
GEO Series GSE138516. Homo sapiens. 31 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Genome-wide and single-cell analyses reveal target gene context-dependent relationship between Crebbp recruitment and both constitutive and signal-responsive gene expression.
GEO Series GSE54454. Mus musculus. 20 samples. Type: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing.
Ets1 confers context-dependent activation of Notch signaling in T-cell leukemia
GEO Series GSE138660. Homo sapiens. 53 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.