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921 results for “corticosteroids”
The Upper-Airway Microbiome as a Biomarker of Asthma Exacerbations despite Inhaled Corticosteroid Treatment
<p>The response to inhaled corticosteroids (ICS) in asthma is affected by the interplay of several factors. Among these, the role of the upper-airway microbiome has been scarcely investigated. We aimed to evaluate the association between the salivary, pharyngeal, and nasal microbiome with asthma exacerbations despite ICS use. Samples from 250 asthma patients from the Genomics and Metagenomics of Asthma Severity (GEMAS) study treated with ICS were analyzed. Controls/cases were defined by the absence/presence of asthma exacerbations in the past six months despite being treated with ICS. The bacterial microbiota was profiled by sequencing the V3-V4 region of the 16S rRNA gene. Differences between groups were assessed by PERMANOVA and regression models adjusted for potential confounders. A false discovery rate (FDR) of 5% was used to correct for multiple comparisons. Classification models of asthma exacerbations despite ICS treatment were built with machine learning approaches based on clinical, genetic, and microbiome data. In nasal and saliva samples, cases had lower bacterial diversity (Richness, Shannon, and Faith indexes) than controls (0.007≤p≤0.037). Asthma exacerbations accounted for 8-9% of the interindividual variation of the salivary and nasal microbiomes (0.003≤p≤0.046). Three, four, and eleven bacterial genera from the salivary, pharyngeal, and nasal microbiomes were differentially abundant between groups (4.09x10<sup>-12</sup>≤FDR≤0.047). Integrating clinical, genetic, and microbiome data showed good discrimination for the development of asthma exacerbations despite ICS use (AUC<sub>training</sub>:0.82 and AUC<sub>validation</sub>:0.77). The diversity and composition of the upper-airway microbiome are associated with asthma exacerbations despite ICS treatment. The salivary microbiome has a potential application as a biomarker of asthma exacerbations despite ICS use.</p> <p>The summary results of the association between bacterial genera and asthma exacerbations despite ICS use are published in this repository. Analyses were conducted using the DESeq2 package adjusting for potential confounders (see more details in the manuscript). The submitted summary tables contains the following columns:</p> <ul> <li>Kingdom: Taxonomic classification at Kingdom level</li> <li>Phylum: Taxonomic classification at Phylum level</li> <li>Class: Taxonomic classification at Class level</li> <li>Order: Taxonomic classification at Order level</li> <li>Family: Taxonomic classification at Family level</li> <li>Genus: Taxonomic classification at Genus level</li> <li>log2FC: log<sub>2</sub>(fold-change). Positive values indicate higher abundance in cases and negative values in controls</li> <li>SE: standard error of log<sub>2</sub>(fold-change)</li> <li>P.Value: p-value of the regression model</li> <li>FDR: adjusted p-value by false discovery rate (Benjamin-Hochberg method)</li> </ul>
Human Genetics Influences Microbiome Composition Involved in Asthma Exacerbations despite Inhaled Corticosteroid Treatment
<p>Additional Supplement Data of the manuscript Perez-Garcia J, Espuela-Ortiz A, Hernández-Pérez JM, et al. Human Genetics Influences Microbiome Composition Involved in Asthma Exacerbations despite Inhaled Corticosteroid Treatment (in press). <em>J Allergy Clin Immunol</em>. 2023;S0091-6749(23)00748-0. doi:10.1016/j.jaci.2023.05.021.</p> <p>This Supplement Data contains the following items:</p> <table> <tbody> <tr> <td>Additional Table 1</td> <td>List of independent mbQTLs associated with p<1x10<sup>-5</sup> in the mbGWAS from saliva samples in Europeans (discovery).</td> </tr> <tr> <td>Additional Table 2</td> <td>List of independent mbQTLs associated with p<1x10<sup>-5</sup> in the mbGWAS from pharyngeal samples in Europeans (discovery).</td> </tr> <tr> <td>Additional Table 3</td> <td>List of independent mbQTLs associated with p<1x10<sup>-5</sup> in the mbGWAS from nasal samples in Europeans (discovery).</td> </tr> <tr> <td>Additional Table 4</td> <td>Summary results of enrichment analyses using the Enrichr platform.</td> </tr> <tr> <td>Additional Table 5</td> <td>Summary results of stratified enrichment analyses by biological sample type.</td> </tr> <tr> <td>Additional Table 6</td> <td>List of independent mbQTLs associated with p<1x10<sup>-5</sup> in the mbGWAS from saliva samples in African Americans (replication phase).</td> </tr> <tr> <td>Additional Table 7</td> <td>List of independent mbQTLs associated with p<1x10<sup>-5</sup> in the mbGWAS from saliva samples in Latinos (replication phase).</td> </tr> <tr> <td>Additional Table 8</td> <td>Summary results of replication enrichment analyses in saliva samples.</td> </tr> <tr> <td>Additional Table 9</td> <td>Summary statistics of the mbQTL analysis of <em>Streptococcus</em> in nasal samples.</td> </tr> <tr> <td>Additional Table 10</td> <td>Summary statistics of the mbQTL analysis of <em>Campylobacter</em> in pharyngeal samples.</td> </tr> <tr> <td>Additional Table 11</td> <td>Summary statistics of the mbQTL analysis of <em>Tannerella</em> in pharyngeal samples.</td> </tr> <tr> <td>Additional Table 12</td> <td>Summary table of the different genetic models tested for each mbQTL pair.</td> </tr> </tbody> </table>
Safety and Efficacy of Ruxolitinib Versus Best Available Therapy in Patients With Corticosteroid-refractory Acute Graft vs. Host Disease After Allogeneic Stem Cell Transplantation
ClinicalTrials.gov study NCT02913261. IPD Sharing: YES. Countries: 22. Publications: 5.
The Standard Care vs. COrticosteroid for REtinal Vein Occlusion (SCORE) Study
ClinicalTrials.gov study NCT00105027. IPD Sharing: YES. Countries: 1. Publications: 15.
Corticosteroid therapy in patients with COVID-19 has little effect on the production of specific antibodies
<p>This excel data includes our research, ”Corticosteroid therapy in patients with COVID-19 has little effect on the production of specific antibodies."</p>
Risk of bias assessments and support for judgement with ROB 2 tool for the Cochrane Review-Update: Systemic corticosteroids for the treatment of COVID-19.
<p>Risk of bias assessments and support for judgement with ROB 2 tool for the Cochrane Review-Update: Systemic corticosteroids for the treatment of COVID-19.</p>
Data of Fig 4 "Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids"
<p>Dataset containes all data of Figure 4 of the publication "Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids" (DOI: 10.3389/fphar.2024.1394846)</p>
Figure 5 "Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids"
<p>Dataset containes all data of Figure 5 of the publication "Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids" (DOI: 10.3389/fphar.2024.1394846)</p>
Dataset of Fig 3 "Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids"
<p>Dataset containes all data of Figure 3 of the publication "Assessment of the potential risk of oteseconazole and two other tetrazole antifungals to inhibit adrenal steroidogenesis and peripheral metabolism of corticosteroids" (DOI: 10.3389/fphar.2024.1394846)</p>
Data for: Corticosteroid-binding globulin (SERPINA6) establishes postpubertal sex differences in rat adrenal development
<p>Encoded by SerpinA6, plasma corticosteroid-binding globulin (CBG) transports glucocorticoids and regulates their access to cells. We determined how CBG influences plasma corticosterone and adrenal development in rats during the pubertal to adult transition using CRISPR/cas9 to disrupt SerpinA6 gene expression. In the absence of CBG, total plasma corticosterone levels were ∼80% lower in adult rats of both sexes, with a greater absolute reduction in females than in males. Notably, free corticosterone and adrenocorticotropic hormone were comparable between all groups. Between 30 and 90 days of age, wild-type female rats showed increases in adrenal weight and the size of the corticosterone-producing region, the zona fasciculata (zf), in tandem with increases in plasma CBG and corticosterone concentrations, whereas no such changes were observed in males. This sex difference was lost in rats without CBG, such that adrenal growth and zf expansion were similar between sexes. The sex-specific effects of CBG on adrenal morphology were accompanied by remarkable changes in gene expression: ∼40% of the adrenal transcriptome was altered in females lacking CBG, whereas almost no effect was seen in males. Over half of the adrenal genes that normally exhibit sexually dimorphic expression after puberty were similarly expressed in males and females without CBG, including those responsible for cholesterol biosynthesis and mobilization, steroidogenesis, and growth. Rat adrenal SerpinA6 transcript levels were very low or undetectable. Thus, sex differences in adrenal growth, morphology and gene expression profiles that emerge during puberty in rats are dependent on concomitant increases in plasma CBG produced by the liver.</p>
Safety and Efficacy of Lebrikizumab (LY3650150) in Combination With Topical Corticosteroid in Moderate-to-Severe Atopic Dermatitis.
ClinicalTrials.gov study NCT04250337. IPD Sharing: YES. Countries: 4. Publications: 1.
Corticosteroids for Acute Migraine in the Emergency Department
ClinicalTrials.gov study NCT02847494. IPD Sharing: NO. Countries: 1. Publications: 1.
Inflammatory Indices in Predicting the Failure of Inhaled Corticosteroids Reduction in Young Participants With Asthma
ClinicalTrials.gov study NCT03788057. IPD Sharing: NO. Countries: 1. Publications: 11.
A Study to Evaluate Upadacitinib in Combination With Topical Corticosteroids in Adolescent and Adult Participants With Moderate to Severe Atopic Dermatitis
ClinicalTrials.gov study NCT03568318. IPD Sharing: YES. Countries: 24. Publications: 10.
The Effects of Corticosteroids, Glucose Control, and Depth-of-Anesthesia on Perioperative Inflammation and Morbidity From Major Non-cardiac Surgery (Dexamethasone, Light Anesthesia and Tight Glucose C
ClinicalTrials.gov study NCT00995501. IPD Sharing: Not stated. Countries: 1. Publications: 4.
A Study Testing the Superiority of CHF 1535 pMDI 800/24µg Total Daily Dose Compared With CHF 718 pMDI 800µg Total Daily Dose in Adults With Asthma on Medium or High-Dose Inhaled Corticosteroid
ClinicalTrials.gov study NCT05292586. IPD Sharing: NO. Countries: 1. Publications: 32.
Corticosteroids in Postoperative Critically Ill Neonates With Low Cardiac Output Syndrome With Congenital Heart Disease
ClinicalTrials.gov study NCT00590018. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Efficacy and Safety Study of Benralizumab Added to High-dose Inhaled Corticosteroid Plus LABA in Patients With Uncontrolled Asthma
ClinicalTrials.gov study NCT01928771. IPD Sharing: Not stated. Countries: 17. Publications: 9.
Nerve Ablation by Cooled Radiofrequency Compared to Corticosteroid Injection for Management of Knee Pain
ClinicalTrials.gov study NCT02343003. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Tralokinumab in Combination With Topical Corticosteroids for Moderate to Severe Atopic Dermatitis - ECZTRA 3
ClinicalTrials.gov study NCT03363854. IPD Sharing: NO. Countries: 8. Publications: 5.
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.