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ShareScore release 0.9.0
Dataset results
16 results for “corticotroph”
USP8 and TP53 drivers are associated with CNV in a corticotroph adenoma cohort enriched for aggressive tumors
<p><b>Context:</b> Pituitary corticotroph adenomas are rare tumors that can be associated with excess adrenocorticotropic hormone (ACTH) and adrenal cortisol production, resulting in the clinically debilitating endocrine condition Cushing disease. A subset of corticotroph tumors behave aggressively, and genomic drivers behind the development of these tumors are largely unknown.</p> <p><b>Objective</b><strong>:</strong> To investigate genomic drivers of corticotroph tumors at risk for aggressive behavior.</p> <p><b>Design:</b> Whole-exome sequencing of patient-matched corticotroph tumor and normal DNA from a patient cohort enriched for tumors at risk for aggressive behavior.</p> <p><b>Setting:</b> Tertiary care center.</p> <p><b>Patients:</b> 27 corticotroph tumors from 22 patients analyzed. 12 tumors were macroadenomas, of which 6 were silent ACTH tumors, 2 were Crooke's cell tumors, and 1 was a corticotroph carcinoma.</p> <p><b>Intervention:</b> Whole-exome sequencing.</p> <p><b>Main outcome measure:</b> Somatic mutation genomic biomarkers.</p> <p><b>Results:</b> We found recurrent somatic mutations in USP8 and TP53 genes, both with higher allelic fractions than other somatic mutations. These mutations were mutually exclusive, with TP53 mutations occurring only in USP8-wildtype (WT) tumors, indicating they may be independent driver genes. USP8-WT tumors were characterized by extensive somatic copy number variation compared to USP8-mutated tumors. Independent of molecular driver status, we found an association between invasiveness, macroadenomas, and aneuploidy.</p> <p><b>Conclusions: </b>Our data suggest that corticotroph tumors may be categorized into a USP8-mutated, genome-stable subtype versus a USP8-WT, genome-disrupted subtype, the latter of which has a TP53-mutated subtype with high level of chromosome instability. These findings could help identify high risk corticotroph tumors, namely those with widespread CNV, that may need closer monitoring and more aggressive treatment.</p>
The expression of glucocorticoid and mineralocorticoid receptors in corticotroph pituitary tumors
<p>Data include the basic clinical parameters of patients with corticotroph pituitary tumors and the results of the measurements of relative expression level of NR3C1 and NR3C2 genes as well as the results of the evaluation of the expression of glucocorticoid and mineralocorticoid receptor. Gene expression was measured with qRT-PCR, protein expression was assessed with immunohistochemistry.</p>
USP8 and TP53 drivers are associated with CNV in a corticotroph adenoma cohort enriched for aggressive tumors
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Data from: PCSK1N as a tumor size marker and an ER stress response protein in corticotroph pituitary adenomas
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Stimulation Test With Intranasal Glucagon for Corticotroph, Somatotroph and Antidiuretic Axes
ClinicalTrials.gov study NCT05206149. IPD Sharing: NO. Countries: 1. Publications: 10.
Pasireotide LAR Therapy of Silent Corticotroph Pituitary Tumors
ClinicalTrials.gov study NCT02749227. IPD Sharing: NO. Countries: 1. Publications: 0.
Osilodrostat Therapy and 11C-methionine PET to Improve Corticotroph Adenoma Detection
ClinicalTrials.gov study NCT06701838. IPD Sharing: NO. Countries: 0. Publications: 11.
Dissection of corticotroph transcriptome in a mouse model of glucocorticoid-induced suppression of the HPA axis
GEO Series GSE165026. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Knockdown of transcription factor Creb3l1 in anterior pituitary mouse corticotroph cell line AtT20
GEO Series GSE147978. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
USP8 mutations determine genes’ expression profile of pituitary corticotroph adenomas, regardless of tumor functional status.
GEO Series GSE132982. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
Microarray analysis of an RXR agonist HX630 regulated gene expression in murine pituitary corticotroph tumor cells (AtT20 cell)
GEO Series GSE43783. Mus musculus. 8 samples. Type: Expression profiling by array.
Differential microRNA Expression in USP8-Mutated and Wild-Type Corticotroph Pituitary Tumors Reflect the Difference in Protein Ubiquitination Processes
GEO Series GSE166279. Homo sapiens. 48 samples. Type: Expression profiling by high throughput sequencing.
Study of Cabergoline in Treatment of Corticotroph Pituitary Tumor
ClinicalTrials.gov study NCT00889525. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Murine corticotroph pituitary AtT-20 cells: Crh treatment time course
GEO Series GSE13156. Mus musculus. 30 samples. Type: Expression profiling by array.
miRNA landscape of corticotroph pituitary neuroendocrine tumor from bilateral petrosal sinus sampling
GEO Series GSE163957. Homo sapiens. 10 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Synergistic Action of LIF and Glucocorticoids on pituitary corticotrophs cell line (AtT-20)
GEO Series GSE19042. Mus musculus. 24 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.