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ShareScore release 0.9.0
Dataset results
31 results for “cortisol responsiveness”
Data of "Poor repeatability of cortisol responses to adrenocorticotropic hormone (ACTH) in beef heifers: is the ACTH challenge a suitable measure for stress research in cattle?"
<p>Data for article "Poor repeatability of cortisol responses to adrenocorticotropic hormone (ACTH) in beef heifers: is the ACTH challenge a suitable measure for stress research in cattle?" Dataset of 64 crossbred beef heifers which were subjected to three ACTH challenges. Both experimental independent variables (animal id, horn status, replicate, time of day of the ACTH challenge, ACTH challenge number) and post-ACTH salivary cortisol concentrations (at the seven sampling timepoints and area under the curve values) are presented.</p>
Cortisol Response to Moderate and Deep Sedation in Children
ClinicalTrials.gov study NCT01265966. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Cortisol Suppression and Startle Responses in Posttraumatic Stress Disorder (PTSD)
ClinicalTrials.gov study NCT01477762. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Severe hypoxia exposure inhibits larval brain development but does not affect the capacity to mount a cortisol stress response in zebrafish
<p>Fish nursery habitats are increasingly hypoxic and the brain is recognized as highly hypoxia-sensitive, yet there is a lack of information on the effects of hypoxia on the development and function of the larval fish brain. Here, we tested the hypothesis that by inhibiting brain development, larval exposure to severe hypoxia has persistent functional effects on the cortisol stress response in zebrafish (<i>Danio rerio</i>). Exposing 5 days post-fertilization (dpf) larvae to 10% dissolved O<sub>2</sub> (DO) for 16 h only marginally reduced survival, but it decreased forebrain neural proliferation by 55%, and reduced the expression of <i>neurod1</i>, <i>gfap,</i> and <i>mbpa, </i>markers of determined neurons, glia, and oligodendrocytes, respectively. The 5 dpf hypoxic exposure also elicited transient increases in whole body cortisol and in <i>crf</i>, <i>uts1</i>, and <i>hsd20b2</i> expression, key regulators of the endocrine stress response. Hypoxia exposure at 5 dpf also inhibited the cortisol stress response to hypoxia in 10 dpf larvae and increased hypoxia tolerance. However, 10% DO exposure at 5 dpf for 16h did not affect the cortisol stress response to a novel stressor in 10 dpf larvae or the cortisol stress response to hypoxia in adult fish. Therefore, while larval exposure to severe hypoxia can inhibit brain development, it also increases hypoxia tolerance. These effects may transiently reduce the impact of hypoxia on the cortisol stress response but not its functional capacity to respond to novel stressors. We conclude that the larval cortisol stress response in zebrafish has a high capacity to cope with severe hypoxia-induced neurogenic impairment.</p>
Cortisol Control of Human Inflammatory Responses to Endotoxin
ClinicalTrials.gov study NCT00396344. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Determination of Method-specific Normal Cortisol and Adrenal Hormone Responses to the Short Synacthen Test
ClinicalTrials.gov study NCT00851942. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Cortisol Response to Adrenocorticotrophin (ACTH) in Acute Stress
ClinicalTrials.gov study NCT00493389. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Effect of Dexmedetomidine on Plasmatic Cortisol Response in Transsphenoidal Surgery
ClinicalTrials.gov study NCT02549768. IPD Sharing: UNDECIDED. Countries: 1. Publications: 9.
Effect of A Single Dose of Lorazepam on Salivary Cortisol Response in Children Undergoing Digestive Endoscopy:
ClinicalTrials.gov study NCT03180632. IPD Sharing: NO. Countries: 1. Publications: 1.
Multimodal Neuroimaging of Alcohol Cues, Cortisol Response, and Compulsive Motivation
ClinicalTrials.gov study NCT04412824. IPD Sharing: NO. Countries: 1. Publications: 1.
Severe hypoxia exposure inhibits larval brain development but does not affect the capacity to mount a cortisol stress response in zebrafish
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Revisiting peak serum cortisol response to insulin-induced hypoglycemia in children and adolescents
<p>Purpose: To evaluate factors that could potentially affect the hypothalamic-pituitary adrenal (HPA) axis response to insulin-induced hypoglycemia in children without history or symptoms of adrenal insufficiency and to propose a cut-off value to define a normal response in this population. Methods: Exploratory single-centre study involving 78 children that prospectively underwent insulin tolerance test (ITT) for suspected growth hormone (GH) deficiency. Methods: Glucose, cortisol, GH, adrenocorticotropic hormone (ACTH), epinephrine and norepinephrine levels were measured at baseline and after insulin-induced hypoglycemia. Serum cortisol was measured using Access automated immunoassay. Results: Mean (range) basal morning serum cortisol of 8 (2.2-19.5) µg/dL/ 222 (61-542) nmol/L increased after hypoglycemia to 20.5 (14.6-29.5) µg/dL / 570 nmol/L (405 -819) nmol/L. Peak serum cortisol levels of 14.6 µg/dL (405nmol/L) and 15.4 µg/dL (428 nmol/L) corresponded to the 2.5<sup>th</sup> and 5<sup>th</sup> percentiles, respectively. Peak serum cortisol correlated with peak plasma epinephrine (r = 0.367; <em>P</em> = 0.0014) but did not correlate with age, BMI-SD or peak serum GH. Children with intact and abnormal GH responses presented similar mean peak serum cortisol levels (20.0 vs. 20.6 µg/dL / 555 vs. 572 nmol/L; <em>P</em> = 0.21). Conclusion: Our data indicate that the current cut-off to define normal HPA axis response in children after insulin-induced hypoglycemia warrants reevaluation in order to avoid overdiagnosis of adrenal insufficiency. Our results suggest that peak serum cortisol levels ³ 15.4 µg/dL (428 nmol/L) in children undergoing ITT might represent a normal cortisol response to stress, regardless of age, BMI or GH secretory capacity.</p>
Thyroid and Cortisol Hormone Response to Sepsis
ClinicalTrials.gov study NCT06289179. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Eszopiclone Treatment & Cortisol Responsivity
ClinicalTrials.gov study NCT00889200. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study to Evaluate Cortisol Reserve in Response to Adrenocorticotropic Hormone (ACTH) Stimulation Test Following Baxdrostat Treatment Compared to Placebo in Participants With Uncontrolled Hypertensio
ClinicalTrials.gov study NCT06336356. IPD Sharing: YES. Countries: 1. Publications: 0.
Data from: Facial attractiveness is related to women’s cortisol and body fat, but not with immune responsiveness
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Data from: Cortisol awakening response is linked to disease course and progression in multiple sclerosis
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Response to low-dose cortisol treatment in zebrafish embryos [larvae]
GEO Series GSE80221. Danio rerio. 6 samples. Type: Expression profiling by high throughput sequencing.
Neural Mechanism of Cortisol Awakening Response Suppression Effect on Human High-order and Social Cognitions
ClinicalTrials.gov study NCT02799134. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Cortisol and Nutritional Sympathetic Responsiveness
ClinicalTrials.gov study NCT01620684. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.