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21
datasets available to search
ShareScore release 0.9.0
Dataset results
21 results for “cross-presentation”
CLEC-1 is a death sensor that limits antigen cross-presentation by dendritic cells and represents a target for cancer immunotherapy
<p>Tumors exploit numerous immune checkpoints including those deployed by myeloid cells to curtail anti-tumor immunity. Here, we show that the C-type lectin receptor CLEC-1 expressed by myeloid cells senses dead cells killed by programmed necrosis. Moreover, we identified TRIM21 as an endogenous ligand over-expressed in various cancers. Interestingly, we observed that in mice CLEC-1 blockade combined with chemotherapy to prolong survival in tumor models. Loss of CLEC-1 reduced the accumulation of immunosuppressive myeloid cells in tumors and invigorated the activation state of dendritic cells (DCs), thereby increasing T cell responses. Mechanistically, we found that the absence of CLEC-1 increased the cross-presentation of dead-cell associated antigens by conventional type-1 DCs. Importantly, we identified anti-human CLEC-1 antagonist antibodies able to enhance anti-tumor immunity in CLEC-1 humanized mice. Altogether, our results demonstrate that CLEC-1 acts as an immune checkpoint in myeloid cells and support CLEC-1 as a novel target for cancer immunotherapy.</p>
Fluorescent tracking identifies tumor migratory dendritic cells as critical for cross-presentation in the lymph node following radiation therapy induced maturation
GEO Series GSE201026. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Antigen cross-presentation in young tumor-bearing hosts promotes CD8 T cell terminal differentiation
GEO Series GSE188389. Homo sapiens; Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
Antigen cross-presentation in young tumor-bearing hosts promotes CD8 T cell terminal differentiation [WGBS]
GEO Series GSE188388. Homo sapiens. 3 samples. Type: Methylation profiling by high throughput sequencing.
DNGR-1 signalling limits dendritic cell activation for optimal antigen cross-presentation
GEO Series GSE287030. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Antigen cross-presentation in young tumor-bearing hosts promotes CD8 T cell terminal differentiation [gene expression]
GEO Series GSE188387. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Increased antigen cross-presentation but impaired cross-priming after activation of PPARγ
GEO Series GSE15616. Mus musculus. 6 samples. Type: Expression profiling by array.
The pore-forming apolipoprotein APOL7C drives phagosomal rupture and antigen cross-presentation by dendritic cells
GEO Series GSE278170. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Distinct transcriptional programs control cross-presentation in classical- and monocyte-derived dendritic cells
GEO Series GSE75015. Mus musculus. 16 samples. Type: Expression profiling by array.
Type I IFN and not TNF, is essential for cyclic di-nucleotide-elicited CTL by a cytosolic cross-presentation pathway
GEO Series GSE101466. Mus musculus. 70 samples. Type: Expression profiling by array.
Specific requirement of the p84/p110γ complex of PI3Kγ for antibody-activated, inducible cross-presentation in murine type 2 DCs
GEO Series GSE273544. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
CD200+ CD8 T Cell Generated through Arginine Deprivation to Activate Macrophage Cross-presentation and Improve Anti-Tumor Immunity [scRNA-Seq]
GEO Series GSE311149. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Cross-presentation by dendritic cells is limited by non-canonical autophagy.
GEO Series GSE133945. Mus musculus. 30 samples. Type: Expression profiling by high throughput sequencing.
Compound screen identifies inhibitor of apoptosis proteins (IAP) antagonist as an inducer of T cell proliferation after cross-presentation by dendritic cells (Mouse)
GEO Series GSE217048. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
CD200+ CD8 T Cell Generated through Arginine Deprivation to Activate Macrophage Cross-presentation and Improve Anti-Tumor Immunity [RNA-Seq 2]
GEO Series GSE311148. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Ms4a7 expression in cDC1s determines cross-presentation and anti-tumor immunity
GEO Series GSE255477. Mus musculus. 40 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
The pore-forming apolipoprotein APOL7C drives phagosomal rupture and antigen cross-presentation by dendritic cells
GEO Series GSE276376. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Viral-directed augmentation of Kupffer cell cross-presentation provokes anti-tumor immunity against liver metastasis
GEO Series GSE284315. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Compound screen identifies inhibitor of apoptosis proteins (IAP) antagonist as an inducer of T cell proliferation after cross-presentation by dendritic cells (Human)
GEO Series GSE217050. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
CD200+ CD8 T Cell Generated through Arginine Deprivation to Activate Macrophage Cross-presentation and Improve Anti-Tumor Immunity [RNA-Seq]
GEO Series GSE311146. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.