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297 results for “ctDNA”
Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma
<p>Code and data for the MS <strong>"Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma"</strong></p>
Point-of-care monitoring of head and neck cancer treatment response and recurrence development using nanopore-based ctDNA consensus sequencing
<p>Circulating tumor DNA (ctDNA) in blood may become a generic biomarker for non-invasive cancer diagnosis and monitoring. However, detection of ctDNA is challenged by the presence of many circulating DNA molecules from healthy cells. We found that single ctDNA molecules can be sequenced with high accuracy by a three-step process consisting of capturing, copying and concatenation of the original double-stranded ctDNA molecules. This innovative approach - called CyclomicsSeq - is unparalleled by any other method in terms of cost-efficiency and speed, allowing point-of-care cancer diagnostics.</p> <p>Within this CPOC, subsidized by the Oncode institute, we have applied our CyclomicsSeq ctDNA test in patients with advanced head and neck cancer squamous cell carcinoma (HNSCC). Head and neck cancer (HNSCC) accounts for 380,000 cancer-related deaths worldwide. For these patients, determining whether a patient responds to the primary chemoradiation treatment is challenging, and non-responders are sometimes identified when other treatment options are no longer possible. By measuring the ctDNA levels in the blood of these patients prior to and during treatment, we aim to identify non-responders at an earlier stage.</p> <p>This dataset contains base calls of TP53 of 47 nanopore sequencing runs. We included 10 patients and 7 controls. For the patients, we have samples of multiple time points (0 = prior to treatment, 1 = 1 week after treatment initiation, etc).</p>
Dynamic ctDNA Assessment in Cervical and Anal Canal Tumors: Optimizing Follow-up and Clinical Outcomes
ClinicalTrials.gov study NCT06640283. IPD Sharing: NO. Countries: 1. Publications: 6.
Ultra-sensitive ctDNA monitoring required for predicting response and resistance to immunotherapy in advanced melanoma
<p>Data and supporting code for the manuscript "Ultra-sensitive ctDNA monitoring required for predicting response and resistance to immunotherapy in advanced melanoma".</p>
Clinical Application of CTDNA in Operable Breast Cancer Patients
ClinicalTrials.gov study NCT02797652. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Comparison of Diagnostic Sensitivity Between ctDNA Methylation and CEA in Colorectal Cancer
ClinicalTrials.gov study NCT05558436. IPD Sharing: UNDECIDED. Countries: 1. Publications: 12.
A Study of On-treatment ctDNA Changes in Chemo-refractory Colorectal Cancer Patients
ClinicalTrials.gov study NCT05487248. IPD Sharing: Not stated. Countries: 2. Publications: 1.
A Study of Atezolizumab Versus Placebo as Adjuvant Therapy in Participants With High-risk Muscle-invasive Bladder Cancer (MIBC) Who Are ctDNA Positive Following Cystectomy
ClinicalTrials.gov study NCT04660344. IPD Sharing: YES. Countries: 24. Publications: 2.
Molecular Profiling and Dynamic Changes of ctDNA in Unresectable Locally Advanced NSCLC
ClinicalTrials.gov study NCT05641870. IPD Sharing: UNDECIDED. Countries: 1. Publications: 15.
Immune Profile Selection By Fraction of ctDNA in Patients With Advanced NSCLC Treated With Immunotherapy
ClinicalTrials.gov study NCT05715229. IPD Sharing: NO. Countries: 1. Publications: 30.
TAS-102 With or Without Celecoxib in ctDNA-defined Minimal Residual Disease in Colorectal Cancer After Completion of Adjuvant Chemotherapy
ClinicalTrials.gov study NCT05343013. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Plasma ctDNA in Patients Undergoing Diagnostic Colonoscopy
ClinicalTrials.gov study NCT02665299. IPD Sharing: YES. Countries: 1. Publications: 1.
Using ctDNA to Detect Minimal Residual Disease After Lung Cancer Resection
ClinicalTrials.gov study NCT05254782. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluation of the ctDNA LUNAR Test in an Average Patient Screening Episode
ClinicalTrials.gov study NCT04136002. IPD Sharing: NO. Countries: 1. Publications: 2.
Predicting the Efficacy and Prognosis of Rectal Cancer Patients Based on ctDNA-MRD Technology
ClinicalTrials.gov study NCT05969938. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Improving Early Detection of Melanoma Recurrence With Circulating Tumor DNA (ctDNA)
ClinicalTrials.gov study NCT05736523. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Circulating Tumor DNA (ctDNA) as a Predictive Biomarker for Immunotherapy in Advanced or Locally Advanced dMMR/MSI-H Colorectal Patients
ClinicalTrials.gov study NCT06098560. IPD Sharing: Not stated. Countries: 1. Publications: 5.
ctDNA Dynamic Monitoring and Its Role of Prognosis in Stage II to IIIA NSCLC by NGS
ClinicalTrials.gov study NCT03465241. IPD Sharing: NO. Countries: 1. Publications: 1.
Predicting BReast cAncer Response to neoadjuVant Therapy by ctDNA Assessment
ClinicalTrials.gov study NCT06087120. IPD Sharing: YES. Countries: 2. Publications: 20.
ctDNA-MRD Monitoring After Resection in Gastric Cancer
ClinicalTrials.gov study NCT06893133. IPD Sharing: UNDECIDED. Countries: 1. Publications: 6.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.