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17 results for “dectin-1”
Dataset related to article "The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell-mediated resistance to metastasis."
<p>The plasma membrane tetraspan molecule MS4A4A is selectively expressed by macrophage-lineage cells, but its function is unknown. Here we report that MS4A4A was restricted to murine and human mononuclear phagocytes and was induced during monocyte-to-macrophage differentiation in the presence of interleukin 4 or dexamethasone. Human MS4A4A was co-expressed with M2/M2-like molecules in subsets of normal tissue-resident macrophages, infiltrating macrophages from inflamed synovium and tumor-associated macrophages. MS4A4A interacted and colocalized with the β-glucan receptor dectin-1 in lipid rafts. In response to dectin-1 ligands, Ms4a4a-deficient macrophages showed defective signaling and defective production of effector molecules. In experimental models of tumor progression and metastasis, Ms4a4a deficiency in macrophages had no impact on primary tumor growth, but was essential for dectin-1-mediated activation of macrophages and natural killer (NK) cell-mediated metastasis control. Thus, MS4A4A is a tetraspan molecule selectively expressed in macrophages during differentiation and polarization, essential for dectin-1-dependent activation of NK cell-mediated resistance to metastasis.</p>
Dectin-1 Stimulation Promotes a Distinct Inflammatory Signature in the Setting of HIV infection and Aging
GEO Series GSE212971. Homo sapiens. 38 samples. Type: Expression profiling by high throughput sequencing.
Genome wide mapping of NFAT1 binding sites in dendritic cells and of chromatin state in steady and dectin-1 activated dendritic cell line D1
GEO Series GSE59998. Mus musculus. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Role of Polymorphisms in the Dectin-1 Gene in Determining the Risk of Candida Colonization and Infection in Critically Ill Patients
ClinicalTrials.gov study NCT01482988. IPD Sharing: Not stated. Countries: 1. Publications: 0.
CARD9-associated Dectin-1 and Dectin-2 are Required for Protective Immunity of a Multivalent Vaccine Against Coccidioides posadasii Infection
GEO Series GSE133140. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Dectin-1/CARD9-induction of the TFEB and TFE3 gene network is dispensable for phagocyte anti-Aspergillus activity in the lung.
GEO Series GSE233353. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Dectin-1 ligands produce distinct training phenotypes in human monocytes through differential activation of signaling networks
GEO Series GSE242947. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profiling of dectin-1 and NFAT responsive genes in dendritic cells
GEO Series GSE59896. Mus musculus. 15 samples. Type: Expression profiling by array.
Dectin-1-mediated signaling leads to characteristic gene expressions in rat mast cells
GEO Series GSE56246. Rattus norvegicus. 6 samples. Type: Expression profiling by array.
Analysis of the role of Dectin-1 in the development of intestinal tumor-infiltrating myeloid cells and intestinal tumorigenesis
GEO Series GSE221206. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Effect of Dectin-1 and Fcgr2b on IVIg mediated reprogramming of monocytes
GEO Series GSE224775. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Analysis of the role of Dectin-1 in the development of intestinal tumor-infiltrating myeloid cells [scRNA-Seq]
GEO Series GSE221204. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Dectin-1 intracellular domain determines species-specific ligand spectrum by modulating receptor sensitivity [mouse]
GEO Series GSE98825. Mus musculus. 2 samples. Type: Expression profiling by array.
Analysis of the role of Dectin-1 in the development of intestinal tumorigenesis [RNA-Seq]
GEO Series GSE221205. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
C1QBP interacts with Dectin-1 signaling to suppress IL-1β via epigenetic silencing in Candida albicans infection
GEO Series GSE313539. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Dectin-1 intracellular domain determines species-specific ligand spectrum by modulating receptor sensitivity
GEO Series GSE98826. Mus musculus; Homo sapiens. 4 samples. Type: Expression profiling by array.
Dectin-1 intracellular domain determines species-specific ligand spectrum by modulating receptor sensitivity [human]
GEO Series GSE98814. Homo sapiens. 2 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.