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119 results for “disease susceptibility”
Genome-wide association analyses identify novel Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility
<p>The Brugada syndrome GWAS summary statistics</p> <p>Brugada syndrome is a cardiac arrhythmia disorder associated with sudden death in young adults. With the exception of <em>SCN5A</em>, encoding the cardiac sodium channel Na<sub>V</sub>1.5, susceptibility genes remain largely unknown. We performed a genome-wide association meta-analysis comprising 2,820 unrelated cases with Brugada syndrome and 10,001 controls.</p> <p> </p>
Data from: Disease resistance is more costly at younger ages: An explanation for the maintenance of juvenile susceptibility
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Data from: A natural gene drive system influences bovine tuberculosis susceptibility in African buffalo: possible implications for disease management
Bovine tuberculosis (BTB) is endemic to the African buffalo (Syncerus caffer) of Hluhluwe-iMfolozi Park (HiP) and Kruger National Park, South Africa. In HiP, the disease has been actively managed since 1999 through a test-and-cull procedure targeting BTB-positive buffalo. Prior studies in Kruger showed associations between microsatellite alleles, BTB and body condition. A sex chromosomal meiotic drive, a form of natural gene drive, was hypothesized to be ultimately responsible. These associations indicate high-frequency occurrence of two types of male-deleterious alleles (or multiple-allele haplotypes). One type negatively affects body condition and BTB resistance in both sexes. The other type has sexually antagonistic effects: negative in males but positive in females. Here, we investigate whether a similar gene drive system is present in HiP buffalo, using 17 autosomal microsatellites and microsatellite-derived Y-chromosomal haplotypes from 401 individuals, culled in 2002-2004. We show that the association between autosomal microsatellite alleles and BTB susceptibility detected in Kruger, is also present in HiP. Further, Y-haplotype frequency dynamics indicated that a sex chromosomal meiotic drive also occurred in HiP. BTB was associated with negative selection of male-deleterious alleles in HiP, unlike positive selection in Kruger. Birth sex ratios were female-biased. We attribute negative selection and female-biased sex ratios in HiP to the absence of a Y-chromosomal sex-ratio distorter. This distorter has been hypothesized to contribute to positive selection of male-deleterious alleles and male-biased birth sex ratios in Kruger. As previously shown in Kruger, microsatellite alleles were only associated with male-deleterious effects in individuals born after wet pre-birth years; a phenomenon attributed to epigenetic modification. We identified two additional allele types: male-specific deleterious and beneficial alleles, with no discernible effect on females. Finally, we discuss how our findings may be used for breeding disease-free buffalo and implementing BTB test-and-cull programs.
Data from: Disentangling the steps of the infection process responsible for juvenile disease susceptibility
<p>1. Juveniles of diverse host taxa, including vertebrates, invertebrates and plants, are more susceptible to parasitic infections than adults, a phenomenon still poorly understood.</p> <p>2. To shed light on the mechanisms underlying this host age effect, we investigated its expression during different steps of the infection process of a bacterial parasite of the planktonic crustacean <i>Daphnia</i>. To do so, we infected juvenile and adult <i>Daphnia magna</i> with the bacterium <i>Pasteuria ramosa</i> and monitored parasite development in experiments specific to different steps of the infection process.</p> <p>3. We did not find an effect of host age on parasite attachment, but found a strong increase in the penetration time of the parasite into hosts with increasing age. Host age at exposure also affected within-host parasite development, which was delayed in old adult <i>D. magna</i> in comparison to young adults and juveniles. Furthermore, parasite clearance was observed only in old adults, suggesting that old hosts have a better immune response than young adults and juveniles.</p> <p>4. Our results reveal a step-specific effect of host age on disease progression, giving support for different hypotheses explaining high juvenile disease susceptibility. While these mechanisms are likely to work independently from each other, earlier steps of the infection process influence later steps, and thus may respond more readily to selection than later steps.</p> <p>5. Our results also highlight that clearance can occur both during early parasite establishment and surprisingly at progressed infection phases, an undocumented phenomenon in invertebrates, where late infections are often considered chronic, lasting until host death.</p>
Data from: Symbiotic immuno-suppression: is disease susceptibility the price of bleaching resistance?
Accelerating anthropogenic climate change threatens to destroy coral reefs worldwide through the processes of bleaching and disease. These major contributors to coral mortality are both closely linked with thermal stress intensified by anthropogenic climate change. Disease outbreaks typically follow bleaching events, but a direct positive linkage between bleaching and disease has been debated. By tracking 152 individual coral ramets through the 2014 mass bleaching in a South Florida coral restoration nursery, we revealed a highly significant negative correlation between bleaching and disease in the Caribbean staghorn coral, Acropora cervicornis. To explain these results, we propose a mechanism for transient immunological protection through coral bleaching: Removal of Symbiodinium during bleaching may also temporarily eliminate suppressive symbiont modulation of host immunological function. We contextualize this hypothesis within an ecological perspective in order to generate testable predictions for future investigation.
Voxel-wise maps for the paper: Longitudinal associations of magnetic susceptibility with clinical severity in Parkinson's disease
<p>This upload contains voxel-wise group level QSM data, and statistical maps for group level results associated with the paper: Longitudinal associations of magnetic susceptibility with clinical severity in Parkinson's disease.</p> <p>The assocaited code for reproducing these statistical maps can be found here: <a href="https://github.com/gecthomas/QSM_PD_longitudinal">gecthomas/QSM_PD_longitudinal (github.com)</a></p>
Data from: Symbiotic immuno-suppression: is disease susceptibility the price of bleaching resistance?
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Data from: A natural gene drive system influences bovine tuberculosis susceptibility in African buffalo: possible implications for disease management
Open the record for dataset details and reuse information.
Data from: Disentangling the steps of the infection process responsible for juvenile disease susceptibility
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Data from: Increased susceptibility of WHIM mice to Papillomavirus-induced disease is dependent upon immune cell dysfunction
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Data from: Increased susceptibility to fungal disease accompanies adaptation to drought in Brassica rapa
Recent studies have demonstrated adaptive evolutionary responses to climate change, but little is known about how these responses may influence ecological interactions with other organisms, including natural enemies. We used a resurrection experiment in the greenhouse to examine the effect of evolutionary responses to drought on the susceptibility of Brassica rapa plants to a fungal pathogen, Alternaria brassicae. In agreement with previous studies in this population, we found an evolutionary shift to earlier flowering post-drought, which was previously shown to be adaptive. Here we report the novel finding that post-drought descendant plants were also more susceptible to disease, indicating a rapid evolutionary shift to increased susceptibility. This was accompanied by an evolutionary shift to increased specific leaf area (thinner leaves) following drought. We found that flowering time and disease susceptibility displayed plastic responses to experimental drought treatments, but that this plasticity did not match the direction of evolution, indicating that plastic and evolutionary responses to changes in climate can be opposed. The observed evolutionary shift to increased disease susceptibility accompanying adaptation to drought provides evidence that even if populations can rapidly adapt in response to climate change, evolution in other traits may have ecological effects that could make species more vulnerable.
Predicting wildlife susceptibility to infectious diseases atglobal scales
<p>Dataset included as supplementary material of the paper entitled https://doi.org/10.5281/zenodo.4914750. It contains phylogenetic, geographical and environmental distance for birds and bats, counts of incidence of <em>Plasmodium relictum</em> on birds, counts of incidence of West Nile Virus on birds and counts of incidence of coronavirus in bats, and susceptibility calculated by the random forest algorithm. Also we include the r scripts to run the models, and the outputs of the models after 1000 runs. </p>
Genetic mutations and decreased protein expression of ABCG2 urate transporters are associated with susceptibility to gout, disease severity and renal-overload hyperuricemia
<p><strong>We are releasing the data and code of our study of clinically defined gouty patients. </strong></p>
Sex-Based Differences in Thyroid Plasma B Cell Infiltration: Implications for Autoimmune Disease Susceptibility - Table S1
<p>This is the supplementary table for the manuscript entitled "Sex-Based Differences in Thyroid Plasma B Cell Infiltration: Implications for Autoimmune Disease Susceptibility"</p>
Isolated Erythrocyte Membrane Susceptibility to Photo-oxidative Stress in Alzheimer's Disease
ClinicalTrials.gov study NCT01707719. IPD Sharing: NO. Countries: 1. Publications: 17.
Genetic Susceptibility to Cardiovascular Disease in Patients on Kidney Dialysis
ClinicalTrials.gov study NCT00340119. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Combined Aerobic Exercise and Cognitive Training in Seniors With Genetic Susceptibility for Alzheimer's Disease
ClinicalTrials.gov study NCT05163067. IPD Sharing: NO. Countries: 1. Publications: 5.
Mapping of End Stage Renal Disease Genetic Susceptibility in African Americans by Admixture Linkage Disequilibrium
ClinicalTrials.gov study NCT00559767. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Genetic Polymorphism Associated With Coronary Heart Disease Susceptibility and Variability of Clopidogrel Response
ClinicalTrials.gov study NCT03373552. IPD Sharing: NO. Countries: 1. Publications: 1.
SARS-CoV-2 (COVID-19) Longitudinal Study: Understanding Susceptibility, Transmission and Disease Severity (Legacy Study)
ClinicalTrials.gov study NCT04750356. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.