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90 results for “dopamine neurons”
Dataset for the manuscript "ExSTED microscopy reveals contrasting functions of dopamine and somatostatin CSF-c neurons along the central canal"
<p>Description: Dataset that supports the expansion-STED and light sheet microscopy methods in spinal cord and support the findings in the manuscript: ExSTED microscopy reveals contrasting functions of dopamine and somatostatin CSF-c neurons along the central canal (Elham Jalalvand, Jonatan Alvelid, Giovanna Coceano, Steven Edwards, Brita Robertson, Sten Grillner, Ilaria Testa).</p> <p>The software used to open the files and perform the analysis: Imspector v0.10_rev8575 and ImageJ 1.52i.</p> <p>The preprint of the manuscript can be found here: https://doi.org/10.1101/2021.08.17.456595</p>
Dataset for: Dopamine neurons that inform Drosophila olfactory memory have distinct, acute functions driving attraction and aversion
<p>The brain must guide immediate responses to beneficial and harmful stimuli while simultaneously writing memories for future reference. While both immediate actions and reinforcement learning are instructed by dopamine, how dopaminergic systems maintain coherence between these two reward functions is unknown. Through optogenetic activation experiments, we showed that the dopamine neurons that inform olfactory memory in Drosophila have a distinct, parallel function driving attraction and aversion (valence). Sensory neurons required for olfactory memory were dispensable to dopaminergic valence. A broadly projecting set of dopaminergic cells had valence that was dependent on dopamine, glutamate, and octopamine. Similarly, a more restricted dopaminergic cluster with attractive valence was reliant on dopamine and glutamate; flies avoided opto-inhibition of this narrow subset, indicating the role of this cluster in controlling ongoing behavior. Dopamine valence was distinct from output-neuron opto-valence in locomotor pattern, strength, and polarity. Overall our data suggest that dopamine’s acute effect on valence provides a mechanism by which a dopaminergic system can coherently write memories to influence future responses while guiding immediate attraction and aversion.</p>
Overlapping representations of food and social stimuli in VTA dopamine neurons
<p>2-photon imaging and behavioral data accompanying publication of "Overlapping representations of food and social stimuli in VTA dopamine neurons" (Lindsay Willmore, Adelaide Minerva, Ben Engelhard, Brenna McMannon, Nirja Oak, Stephan Thiberge, Malavika Murugan, Catherine Jensen Pena, Ilana Witten). This dataset contains all information required to recreate figures from the paper. </p>
Overlapping representations of food and social stimuli in VTA dopamine neurons
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Mesolimbic dopamine neurons drive infradian rhythms in sleep-wake and heightened activity state
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Data for Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration
<p>Raw Data for publication titled Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration.</p>
Interspecies chimerism with human embryonic stem cells generates functional human dopamine neurons at low efficiency
<p>Interspecies chimeras offer great potential for regenerative medicine and creation of human disease models. Whether human pluripotent stem cell (hPSC) derived neurons in an interspecies chimera can differentiate into functional neurons and integrate into host neural circuity is not known. Here we show, using Engrailed 1 (En1) as a development niche that human naïve-like ES cells can incorporate into embryonic and adult mouse brains. Human-derived neurons including tyrosine hydroxylase (TH) positive neurons integrate into the mouse brain at low efficiency. These TH-positive neurons have electrophysiologic properties consistent with their human origin. Additionally, these human-derived neurons in the mouse brain accumulate pathologic phosphorylated α-synuclein in response to α-synuclein preformed fibrils. Optimization of human/mouse chimeras could be utilized to study human neuronal differentiation and human brain disorders.</p>
Data from: Neuronal function and dopamine signaling evolve at high temperature in Drosophila
<p>Neuronal activity is temperature sensitive and affects behavioral traits important for individual fitness, such as locomotion and courtship. Yet, we do not know enough about the evolutionary response of neuronal phenotypes in new temperature environments. Here, we use long-term experimental evolution of <em>Drosophila simulans</em> populations exposed to novel temperature regimes. Here, we demonstrate a direct relationship between thermal selective pressure and the evolution of neuronally expressed molecular and behavioral phenotypes. Several essential neuronal genes evolve lower expression at high temperatures and higher expression at low temperatures, with dopaminergic neurons standing out by displaying the most consistent expression change across independent replicates. We functionally validate the link between evolved gene expression and behavioral changes by pharmacological intervention in the experimentally evolved <em>D. simulans</em> populations as well as by genetically triggered expression changes of key genes in <em>D. melanogaster</em>. As natural temperature clines confirm our results for <em>Drosophila</em> and <em>Anopheles</em>populations, we conclude that neuronal dopamine evolution is a key factor for temperature adaptation.</p>
DA Diffusion Simulation for: A fluorescent nanosensor paint reveals the heterogeneity of dopamine release from neurons at individual release sites
<p>Code developed for the revision of:</p> <p>Elizarova, S., Chouaib, A., Shaib, A., Mann, F., Brose, N., Kruss, S., & Daniel, J. A. (2021). A fluorescent nanosensor paint reveals the heterogeneity of dopamine release from neurons at individual release sites. BioRxiv, 2021.03.28.437019. https://doi.org/10.1101/2021.03.28.437019</p>
Population and single dopamine neuron activity during classical conditioning
<p>We trained naive or trained mice to associate odor cues with outcome (water, air puff or no outcome), and recorded dopamine cell body activity in the vetral tegmental area (VTA), dopamine axon activity in the ventral striatum (VS) or dopamine release in VS with optic fiber fluorometry (photometry). In different set of mice, single dopamine neuron activiy was recorded with 2-photon microscope. In some of these mice, we reversed odor-outcome contingency so that an odor that was associated with no outcome or air puff became associated with water reward. Licking pattern was also recorded.</p>
MERFISH Dataset of Mouse Dopamine Neurons_03Jul2024
<p>Cell_by_gene and Cell_metadata files from MERFISH runs of mouse Midbrain spatial transcriptomics. Datasets are setup to be analyzed using Seurat v5.</p>
Characterizing the diversity of enteric neurons using Dopamine Transporter (DAT)-Cre reporter mice
<p>The enteric nervous system (ENS) comprises a complex network of neurons whereby a subset appears to be dopaminergic, although the characteristics, roles, and implications in disease are less understood. Most investigations relating to enteric dopamine (DA) neurons rely on immunoreactivity to tyrosine hydroxylase (TH) - a rate-limiting enzyme in the production of DA. However, TH immunoreactivity is likely to provide an incomplete picture given previous work has showed that some DA neurons contain little if any TH and its levels tend to be decreased in response to cellular stress. The study herein provides a comprehensive characterization of DA neurons in the gut using a well-accepted reporter mouse line, expressing a fluorescent protein under control of the DA transporter (DAT) promoter. Our findings confirm a unique localization of DA neurons in the gut and unveil the discrete subtypes of DA neurons in this organ, which we characterized using both immunofluorescence and single-cell transcriptomics, validated by <em>in situ</em>hybridization. We observed distinct subtypes of DAT neurons expressing co-transmitters and modulators across both plexuses; some of them likely co-releasing acetylcholine, and a smaller population likely releasing nitric oxide; while others were positive for a slew of canonical DA markers. Interestingly, we uncovered a seemingly novel population of DA neurons unique to the ENS which were ChAT/DAT-positive neurons and characterised by the expression of <em>Th</em>, <em>Grp</em>,<em>Calcb</em> and<em> Sst</em>. Given the clear heterogeneity of DAergic gut neurons, further investigation is warranted to define their functional signatures and discover any inherent vulnerabilities in disease. </p>
Single unit electrophysiology of optogenetically identified dopamine neurons in classical conditioning with probabilistic outcome of reward and punishment
<p>We collected single-unit data (.mat file) from optogenetically identified dopamine neurons in the lateral VTA in mice. These dopamine neurons were recorded while animals performed 4 different variation of classical conditioning tasks with different ratio of probabilistic outcomes of water reward and aversive air puff. In one task, one cue was associated with both water and puff in a probabilistic manner.</p>
Interspecies chimerism with human embryonic stem cells generates functional human dopamine neurons at low efficiency
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Data from: Neuronal function and dopamine signaling evolve at high temperature in Drosophila
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Single unit electrophysiology of optogenetically identified dopamine neurons in classical conditioning with probabilistic outcome of reward and punishment
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An endogenous GLP-1 circuit engages VTA GABA neurons to regulate mesolimbic dopamine neurons and attenuate cocaine seeking
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Population and single dopamine neuron activity during classical conditioning
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Cortical VIP neurons as a critical node for dopamine actions
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Data from: Glutamate sensor and calcium signals in dopamine neurons and dopamine release
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.